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Medications and Drugs

Brand Names: Xyralid

Generic Name: hydrocortisone and lidocaine topical (Pronunciation: HYE droe KOR ti sone and LYE doe kane TOP ik al)

What is hydrocortisone and lidocaine topical (Xyralid)?

Hydrocortisone is a topical (for the skin) steroid. It reduces the actions of chemicals in the body that cause inflammation, redness, and swelling.

Lidocaine is a local anesthetic (numbing medication). It works by blocking nerve signals in your body.

Hydrocortisone and lidocaine topical is used to treat itching and inflammation of the skin caused by a number of conditions such as allergic reactions, eczema, psoriasis, minor burns, or insect bites.

Hydrocortisone and lidocaine topical may also be used for other purposes not listed in this medication guide.

What are the possible side effects of hydrocortisone and lidocaine topical (Xyralid)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have severe irritation or swelling of any treated skin, or if you show signs of absorbing hydrocortisone topical through your skin, such as:

  • blurred vision, or seeing halos around lights;
  • mood changes;
  • sleep problems (insomnia);
  • weight gain, puffiness in your face; or
  • muscle weakness, feeling tired.

Less serious side effects may include:

  • mild irritation, redness, or swelling where the medication is applied;
  • thinning of your skin;
  • numbness in places where the medicine is accidentally applied.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about hydrocortisone and lidocaine topical (Xyralid)?

Do not cover treated skin areas with a bandage or other covering unless your doctor has told you to. Covering the skin that is treated with hydrocortisone and lidocaine topical can increase the amount of the drug your skin absorbs, which may lead to unwanted side effects. Follow your doctor's instructions.

Your body may absorb more of this medication if you use too much, if you apply it over large skin areas, or if you apply heat, bandages, or plastic wrap to treated skin areas. Skin that is cut or irritated may also absorb more topical medication than healthy skin.

Avoid using this medication on body areas where you have skin folds or thin skin, unless your doctor has told you to.

Do not use this medication on a child without a doctor's advice. Children are more sensitive to the effects of hydrocortisone and lidocaine topical.

Hydrocortisone and lidocaine topical will not treat a bacterial, fungal, or viral skin infection.

Contact your doctor if your condition does not improve or if it gets worse after using this medication for several days.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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