Hyperthyroidism Glossary of Medical Terms

Ablation: Removal or excision. Ablation is usually carried out surgically. For example, surgical removal of the thyroid gland (a total thyroidectomy) is ablation of the thyroid. The word ablation comes from the Latin ablatum meaning to carry away.
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Abnormal: Not normal. Deviating from the usual structure, position, condition, or behavior. In referring to a growth, abnormal may mean that it is cancerous or premalignant (likely to become cancer ).
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Adenoma: A benign tumor that arises in or resembles glandular tissue. If it becomes cancerous, it is called an adenocarcinoma.
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Agranulocytosis: A marked decrease in the number of granulocytes. Granulocytes are a type of white blood cell filled with microscopic granules that are little sacs containing enzymes that digest microorganisms.
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Assay: An assay is an analysis done to determine:

1. The presence of a substance and the amount of that substance. Thus, an assay may be done for example to determine the level of thyroid hormones in the blood of a person suspected of being hypothyroid (or hyperthyroid).
2. The biological or pharmacological potency of a drug. For example, an assay may be done of a vaccine to determine its potency.

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Atenolol : A medication that blocks the action of a portion of the involuntary nervous system that stimulates the pace of the heartbeat. By blocking the action of these nerves, atenolol reduces the heart rate and is useful in treating abnormally rapid heart rhythms. Atenolol also reduces the force of heart muscle contraction, lowers blood pressure, and is helpful in treating angina . It is also used for the prevention of migraine headaches and the treatment of certain types of tremors. The brand name is Tenormin. Generic is available.
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Baseline: 1. Information gathered at the beginning of a study from which variations found in the study are measured.
2. A known value or quantity with which an unknown is compared when measured or assessed.
3. The initial time point in a clinical trial, just before a participant starts to receive the experimental treatment which is being tested. At this reference point, measurable values such as CD4 count are recorded. Safety and efficacy of a drug are often determined by monitoring changes from the baseline values.
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Beta adrenergic blocking drugs: A class of drugs, also called beta blockers , that block beta-adrenergic substances such as adrenaline (epinephrine), a key agent in the "sympathetic" portion of the autonomic (involuntary) nervous system.
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Bowel: Another name for the intestine . The small bowel and the large bowel are the small intestine and large intestine , respectively.
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Breast milk: Milk from the breast . Human milk contains a balance of nutrients that closely matches infant requirements for brain development, growth and a healthy immune system . Human milk also contains immunologic agents and other compounds that act against viruses , bacteria , and parasites. Since an infant's immune system is not fully developed until age 2, human milk provides a distinct advantage over formula.
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Breastfeeding: Feeding a child human breast milk . According to the American Academy of Pediatrics , human breast milk is preferred for all infants. This includes even premature and sick babies, with rare exceptions. It is the food least likely to cause allergic reactions; it is inexpensive; it is readily available at any hour of the day or night; babies accept the taste readily; and the antibodies in breast milk can help a baby resist infections.
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Calcium: A mineral found mainly in the hard part of bones, where it is stored. Calcium is added to bones by cells called osteoblasts and is removed from bones by cells called osteoclasts. Calcium is essential for healthy bones. It is also important for muscle contraction, heart action, nervous system maintenance, and normal blood clotting. Food sources of calcium include dairy foods, some leafy green vegetables such as broccoli and collards, canned salmon, clams, oysters, calcium-fortified foods, and tofu. According to the National Academy of Sciences, adequate intake of calcium is 1,200 milligrams a day (four glasses of milk) for men and women 51 and older, 1,000 milligrams a day for adults 19 through 50, and 1,300 milligrams a day for children 9 through 18. The upper limit for calcium intake is 2.5 grams daily. Learn more about Calcium with evidence-based information on RxList.

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Cardiac: Having to do with the heart.
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Circulation: The movement of fluid in a regular or circuitous course. Although the noun "circulation" does not necessarily refer to the circulation of the blood, for all practical purposes today it does. Heart failure is an example of a problem with the circulation.
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Contrast: Short for "contrast media." Contrast media are X-ray dyes used to provide contrast, for example, between blood vessels and other tissue.
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Diabetes: Refers to diabetes mellitus or, less often, to diabetes insipidus . Diabetes mellitus and diabetes insipidus share the name "diabetes" because they are both conditions characterized by excessive urination (polyuria).
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Diagnosis: 1 The nature of a disease ; the identification of an illness. 2 A conclusion or decision reached by diagnosis. The diagnosis is rabies . 3 The identification of any problem. The diagnosis was a plugged IV.
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Diarrhea : A familiar phenomenon with unusually frequent or unusually liquid bowel movements, excessive watery evacuations of fecal material. The opposite of constipation . The word "diarrhea" with its odd spelling is a near steal from the Greek "diarrhoia" meaning "a flowing through." Plato and Aristotle may have had diarrhoia while today we have diarrhea. There are myriad infectious and noninfectious causes of diarrhea.
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Diffuse toxic goiter: Graves disease, the most common cause of hyperthyroidism (overactivity of the thyroid gland), with generalized diffuse overactivity ("toxicity") of the entire thyroid gland which becomes enlarged into a goiter .
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Diplopia: The condition in which a single object appears as two objects. Also called "double vision." From the Greek diplo- (double) + -opia (vision). See also: Diplopia, binocular ; Diplopia, monocular .
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Dysfunction: Difficult function or abnormal function.
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Endocrine: Pertaining to hormones and the glands that make and secrete them into the bloodstream through which they travel to affect distant organs. The endocrine sites include the hypothalamus, pituitary gland, pineal gland, thyroid, parathyroids, heart (which makes atrial-natriuretic peptide), the stomach and intestines, islets of Langerhans in the pancreas, the adrenal glands, the kidney (which makes renin, erythropoietin , and calcitriol), fat cells (which make leptin). the testes, the ovarian follicle ( estrogens ) and the corpus luteum in the ovary). Endocrine is as opposed to exocrine. (The exocrine glands include the salivary glands, sweat glands and glands within the gastrointestinal tract.)
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Endocrinology: The study of hormones , their receptors , the intracellular signalling pathways they invoke, and the diseases and conditions associated with them.
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Enlarged thyroid: see goiter .
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Estrogen: Estrogen is a female hormone produced by the ovaries. Estrogen deficiency can lead to osteoporosis .
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Euthyroid: The state of having normal thyroid gland function. As opposed to hyperthyroid (overactive thyroid) and hypothyroid (underactive thyroid).
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Exophthalmos: Protruding eyeball. A common finding in hyperthyroidism (too much thyroid hormone) of Graves disease.
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False positive: A result that is erroneously positive when a situation is normal. An example of a false positive: a particular test designed to detect cancer of the toenail is positive but the person does not have toenail cancer.
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Fatigue: A condition characterized by a lessened capacity for work and reduced efficiency of accomplishment, usually accompanied by a feeling of weariness and tiredness. Fatigue can be acute and come on suddenly or chronic and persist.
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Fertility: The ability to conceive and have children, the ability to become pregnant through normal sexual activity. Infertility is defined as the failure to conceive after a year of regular intercourse without contraception.
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Gland: 1. A group of cells that secrete a substance for use in the body. For example, the thyroid gland. 2. A group of cells that removes materials from the circulation. For example, a lymph gland.
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Goiter: Enlargement of the thyroid gland .
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Heart: The muscle that pumps blood received from veins into arteries throughout the body. It is positioned in the chest behind the sternum (breastbone; in front of the trachea, esophagus, and aorta; and above the diaphragm muscle that separates the chest and abdominal cavities. The normal heart is about the size of a closed fist, and weighs about 10.5 ounces. It is cone-shaped, with the point of the cone pointing down to the left. Two-thirds of the heart lies in the left side of the chest with the balance in the right chest.
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Heart rate: The number of heart beats per unit time, usually per minute. The heart rate is based on the number of contractions of the ventricles (the lower chambers of the heart). The heart rate may be too fast ( tachycardia ) or too slow ( bradycardia ). The pulse is bulge of an artery from the wave of blood coursing through the blood vessel as a result of the heart beat. The pulse is often taken at the wrist to estimate the heart rate.
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Hepatitis: Inflammation of the liver from any cause.
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Hormone: A chemical substance produced in the body that controls and regulates the activity of certain cells or organs.
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Hyperthyroid: Excess of thyroid hormone resulting from an overactive thyroid gland (or taking too much thyroid hormone). Symptoms can include increased heart rate, weight loss, depression , and cognitive slowing. Treatment is by medication, the use of radioactive iodine, thyroid surgery, or reducing the dose of thyroid hormone.
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Immune: Protected against infection. The Latin immunis means free, exempt.
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Immune system: A complex system that is responsible for distinguishing us from everything foreign to us, and for protecting us against infections and foreign substances. The immune system works to seek and kill invaders.
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Indicate: In medicine, to make a treatment or procedure advisable because of a particular condition or circumstance. For example, certain medications are indicated for the treatment of hypertension during pregnancy while others are contraindicated .
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Infection: The growth of a parasitic organism within the body. (A parasitic organism is one that lives on or in another organism and draws its nourishment therefrom.) A person with an infection has another organism (a "germ") growing within him, drawing its nourishment from the person.
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Inflammation: A basic way in which the body reacts to infection , irritation or other injury, the key feature being redness, warmth, swelling and pain . Inflammation is now recognized as a type of nonspecific immune response .
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Insomnia: The perception or complaint of inadequate or poor-quality sleep because of one or more of the following: difficulty falling asleep; waking up frequently during the night with difficulty returning to sleep; waking up too early in the morning; or unrefreshing sleep. Insomnia is not defined by the number of hours of sleep a person gets or how long it takes to fall asleep. Individuals vary normally in their need for, and their satisfaction with, sleep. Insomnia may cause problems during the day, such as tiredness, a lack of energy, difficulty concentrating, and irritability.
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Iodine: An essential element in the diet used by the thyroid gland to make thyroid hormones .
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Laboratory: A place for doing tests and research procedures and preparing chemicals, etc. Although "laboratory" looks very like the Latin "laboratorium" (a place to labor, a work place), the word "laboratory" came from the Latin "elaborare" (to work out, as a problem, and with great pains), as evidenced by the Old English spelling "elaboratory" designating "a place where learned effort was applied to the solution of scientific problems."
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Leg: In popular usage, the leg extends from the top of the thigh down to the foot. However, in medical terminology, the leg refers to the portion of the lower extremity from the knee to the ankle.
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Lower leg: The lower leg is the bottom segment of the leg: the part below the knee.
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Menstrual: Pertaining to menstruation (the menses), as in last menstrual period , menstrual cramps , menstrual cycle , and premenstrual syndrome . From the Latin menstrualis, from mensis meaning month.
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Metabolism: The whole range of biochemical processes that occur within us (or any living organism). Metabolism consists both of anabolism and catabolism (the buildup and breakdown of substances, respectively). The term is commonly used to refer specifically to the breakdown of food and its transformation into energy.
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Muscle: Muscle is the tissue of the body which primarily functions as a source of power. There are three types of muscle in the body. Muscle which is responsible for moving extremities and external areas of the body is called "skeletal muscle." Heart muscle is called "cardiac muscle." Muscle that is in the walls of arteries and bowel is called "smooth muscle."
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Nerve: A bundle of fibers that uses chemical and electrical signals to transmit sensory and motor information from one body part to another. See: Nervous system .
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Nodular: Bumpy.
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Nodule: A small solid collection of tissue, a nodule is palpable (can be felt). It may range in size from greater than 1.0 cm (3/8 inch) to somewhat less than 2 cm (13/16 inch) in diameter. A nodule may be present in the epidermis, dermis or subcutis (at any level in the skin).
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Nutrition : 1) The science or practice of taking in and utilizing foods. 2) A nourishing substance, such as nutritional solutions delivered to hospitalized patients via an IV or IG tube.
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Palpitations: Unpleasant sensations of irregular and/or forceful beating of the heart. In some patients with palpitations , no heart disease or abnormal heart rhythms can be found. In others, palpitations result from abnormal heart rhythms (arrhythmias). Arrhythmias refer to heartbeats that are too slow, too rapid, irregular, or too early.
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Paralysis: Loss of voluntary movement (motor function). Paralysis that affects only one muscle or limb is partial paralysis, also known as palsy; paralysis of all muscles is total paralysis, as may occur in cases of botulism .
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Photophobia: Painful oversensitivity to light. For example, there is photophobia in measles (rubeola). Keeping the lights dim or the room darkened may be useful. Sunglasses may also help.
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Pituitary: 1. As an adjective, pertaining to the pituitary gland or its hormonal secretions. 2. As a noun, the pituitary gland itself.
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Plummer's disease: Toxic multinodular goiter . Also called Parry's disease .
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Prealbumin: One of several plasma proteins such as transthyretin that migrate faster than albumin in an acidic starch gel.
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Pregnancy : The state of carrying a developing embryo or fetus within the female body. This condition can be indicated by positive results on an over-the-counter urine test, and confirmed through a blood test, ultrasound, detection of fetal heartbeat, or an X-ray. Pregnancy lasts for about nine months, measured from the date of the woman's last menstrual period (LMP). It is conventionally divided into three trimesters, each roughly three months long.
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Prognosis: 1. The expected course of a disease .
2. The patient's chance of recovery.
The prognosis predicts the outcome of a disease and therefore the future for the patient . His prognosis is grim, for example, while hers is good.
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PTU: Propylthiouracil, an antithyroid medication, a drug that blocks the production of thyroid hormone by the thyroid gland. PTU is used to treat hyperthyroidism in order to reduce the excessive thyroid activity before surgery and to treat and maintain patients not having surgery.
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Radioactive: Emitting energy waves due to decaying atomic nuclei. Radioactive substances are used in medicine as tracers for diagnosis, and in treatment to kill cancerous cells.
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Radioactive iodine: An isotope of the chemical element iodine that is radioactive . Radioactive iodine is used in diagnostic tests as well as in radiotherapy of an hyperactive thyroid gland (hyperthyroidism), most often due to Graves disease .
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Radioimmunoassay: A very sensitive, specific laboratory test (assay) using radiolabeled (and unlabeled) substances in an immunological (antibody-antigen) reaction.
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Radioiodine: An isotope of the chemical element iodine that is radioactive . Radioiodine is used in diagnostic tests as well as in radiotherapy of an hyperactive thyroid gland ( hyperthyroidism ), most often due to Graves disease .
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Radiology: The branch of medicine that uses ionizing and nonionizing radiation for the diagnosis and treatment of disease.
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Receptor: 1. In cell biology, a structure on the surface of a cell (or inside a cell) that selectively receives and binds a specific substance. There are many receptors. There is a receptor for ( insulin ; there is a receptor for low-density lipoproteins ( LDL ); etc. To take an example, the receptor for substance P, a molecule that acts as a messenger for the sensation of pain , is a unique harbor on the cell surface where substance P docks. Without this receptor, substance P cannot dock and cannot deliver its message of pain. Variant forms of nuclear hormone receptors mediate processes such as cholesterol metabolism and fatty acid production. Some hormone receptors are implicated in diseases such as diabetes and certain types of cancer. A receptor called PXR appears to jump-start the body's response to unfamiliar chemicals and may be involved in drug-drug interactions.
2. In neurology, a terminal of a sensory nerve that receives and responds to stimuli.
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Recurrent: Back again. A recurrent fever is a fever that has returned after an intermission: a recrudescent fever.
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Resistance: Opposition to something, or the ability to withstand it. For example, some forms of staphylococcus are resistant to treatment with antibiotics.
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Scan: As a noun, the data or image obtained from the examination of organs or regions of the body by gathering information with a sensing device.
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Sensitivity: 1. In psychology, the quality of being sensitive. As, for example, sensitivity training, training in small groups to develop a sensitive awareness and understanding of oneself and of ones relationships with others. 2. In disease epidemiology, the ability of a system to detect epidemics and other changes in disease occurrence. 3. In screening for a disease, the proportion of persons with the disease who are correctly identified by a screening test. 4. In the definition of a disease, the proportion of persons with the disease who are correctly identified by defined criteria.
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Serum: The clear liquid that can be separated from clotted blood. Serum differs from plasma, the liquid portion of normal unclotted blood containing the red and white cells and platelets. It is the clot that makes the difference between serum and plasma.
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Shin: 1. The tibia , the larger of the two bones in the lower leg .
2. The anterior aspect (front) of the tibia.
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Shortness of breath: Difficulty in breathing . Medically referred to as dyspnea . Shortness of breath can be caused by respiratory (breathing passages and lungs ) or circulatory ( heart and blood vessels) conditions. See also dyspnea.
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Sleep : The body's rest cycle.
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Subacute: Rather recent onset or somewhat rapid change. The term "subacute" is used in contrast to acute which indicates very sudden onset or rapid change and chronic which indicates indefinite duration or virtually no change. A chronic condition is one lasting 3 months or more, by the definition of the U.S. National Center for Health Statistics. In ancient Greece, the "father of medicine" Hippocrates distinguished diseases that were acute (abrupt, sharp and brief) from those that were chronic. This is still a very useful distinction. Subacute has been coined to designate the mid-ground between acute and chronic.
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Surgery: The word "surgery" has multiple meanings. It is the branch of medicine concerned with diseases and conditions which require or are amenable to operative procedures. Surgery is the work done by a surgeon. By analogy, the work of an editor wielding his pen as a scalpel is s form of surgery. A surgery in England (and some other countries) is a physician's or dentist's office.
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Sweating: The act of secreting fluid from the skin by the sweat (sudoriferous) glands. These are small tubular glands situated within and under the skin (in the subcutaneous tissue). They discharge by tiny openings in the surface of the skin.
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Symptomatic: 1 With symptoms, as a symptomatic infection . 2 Characteristic, as behavior symptomatic of Huntington disease . 3 Directed at the symptoms, as symptomatic treatment .
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Symptomatic treatment: Therapy that eases the symptoms without addressing the basic cause of the disease.
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Tachycardia: A rapid heart rate, usually defined as greater than 100 beats per minute. The tachycardias include sinus tachycardia , paroxysmal atrial tachycardia (PAT), and ventricular tachycardia .
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Tenormin: See: Atenolol .
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Therapy: The treatment of disease .
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Thyroid: 1. The thyroid gland . Also, pertaining to the thyroid gland. 2. A preparation of the thyroid gland used to treat hypothyroidism . 3. Shaped like a shield. (The thyroid gland was so-named by Thomas Wharton in 1656 because it was shaped like an ancient Greek shield.)
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Thyroid gland: A gland that makes and stores hormones that help regulate the heart rate, blood pressure, body temperature, and the rate at which food is converted into energy. Thyroid hormones are essential for the function of every cell in the body. They help regulate growth and the rate of chemical reactions ( metabolism ) in the body. Thyroid hormones also help children grow and develop.
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Thyroid hormone: A chemical substance made by the thyroid gland for export into the bloodstream. The thyroid gland needs iodine to make thyroid hormones. The two most important thyroid hormones are thyroxine (T4) and triiodothyronine (T3).
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Thyroid hormones: Chemical substances made by the thyroid gland, which is located in the front of the neck. This gland uses iodine to make thyroid hormones, which are essential for the function of every cell in the body. They help regulate growth and the rate of chemical reactions (metabolism), and are involved in the circadian rhythms that govern sleep , among other essential functions.
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Thyroid scan: An image taken of the thyroid gland after radioactive iodine is taken by mouth. The thyroid gland is in front of the neck:

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Thyroid stimulating hormone: A hormone produced by the pituitary gland at the base of the brain in response to signals from the hypothalamus gland in the brain. Thyroid stimulating hormone (TSH) promotes the growth of the thyroid gland in the neck and stimulates it to produce more thyroid hormones . When there is an excessive amount of thyroid hormones, the pituitary gland stops producing TSH, reducing thyroid hormone production. This mechanism maintains a relatively constant level of thyroid hormones circulating in the blood.
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Thyroidectomy: The surgical removal of part or all of the thyroid gland .

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Thyroiditis : Inflammation of the thyroid gland which is located in front of the neck:

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Thyroxine: Abbreviated T4. A hormone made by the thyroid gland that has four iodine molecules attached to its molecular structure. T4 and other thyroid hormones help regulate growth and control the rate of chemical reactions (metabolism) in the body.
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Toxic multinodular goiter: Condition in which the thyroid gland contains multiple lumps (nodules) that are overactive, produce excess thyroid hormones and thereby cause hyperthyroidism . This condition is also known as Parry's disease or Plummer's disease.
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Tremor: Any abnormal repetitive shaking movement of the body. Tremors have many causes and can be inherited, be related to illnesses such as thyroid disease , or caused by fever , hypothermia, drugs or fear.
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Triiodothyronine: A hormone made by the thyroid gland. It has three iodine molecules attached to its molecular structure. It is the most powerful thyroid hormone, and affects almost every process in the body, including body temperature, growth, and heart rate.
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TSH: Stands for thyroid stimulating hormone, a hormone produced by the pituitary gland at the base of the brain in response to signals from the hypothalamus gland in the brain. TSH promotes the growth of the thyroid gland in the neck and stimulates it to produce more thyroid hormones . When there is an excessive amount of thyroid hormones, the pituitary gland stops producing TSH, reducing thyroid hormone production. This mechanism maintains a relatively constant level of thyroid hormones circulating in the blood.
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TSH receptor: The receptor for thyroid stimulating hormone (TSH), which is also called thyrotropin. Encoded by a gene on chromosome 14q, TSHR is largest of all known glycoprotein hormone receptors. It is one of the primary antigens in autoimmune thyroid disease. Autoantibodies to TSHR act as TSH agonists in Graves disease and as TSH antagonists in Hashimoto thyroiditis.
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TSI: Stands for Thyroid Stimulating Immunoglobulin. The TSI level is abnormally high in persons with hyperthyroidism (too much thyroid hormone) due to Graves' disease. Thyroid hormones are essential for the function of every cell in the body. They help regulate growth and the rate of chemical reactions (metabolism) in the body.
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Viral: Of or pertaining to a virus. For example, "My daughter has a viral rash ."
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Viral infection: Infection caused by the presence of a virus in the body. Depending on the virus and the person's state of health, various viruses can infect almost any type of body tissue, from the brain to the skin. Viral infections cannot be treated with antibiotics; in fact, in some cases the use of antibiotics makes the infection worse. The vast majority of human viral infections can be effectively fought by the body's own immune system , with a little help in the form of proper diet, hydration, and rest. As for the rest, treatment depends on the type and location of the virus, and may include anti-viral or other drugs.
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Voice box: The voice box, or larynx, is the portion of the respiratory (breathing) tract containing the vocal cords which produce sound. It is located between the pharynx and the trachea. The larynx, also called the voice box, is a 2-inch-long, tube-shaped organ in the neck.

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Weight loss: Weight loss is a decrease in body weight resulting from either voluntary ( diet , exercise ) or involuntary (illness) circumstances. Most instances of weight loss arise due to the loss of body fat, but in cases of extreme or severe weight loss, protein and other substances in the body can also be depleted. Examples of involuntary weight loss include the weight loss associated with cancer , malabsorption (such as from chronic diarrheal illnesses ), and chronic inflammation (such as with rheumatoid arthritis ).
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