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Hyperthyroidism (cont.)

Hyperthyroidism as a Result of Other Medical Treatments

Amiodarone therapy

  • Amiodarone is a drug used in the treatment of abnormal heart rhythms. Amiodarone tablets (Cordarone, Pacerone) contain iodine, and up to 10% of people taking this medication develop abnormalities in thyroid function.
    • Patients taking amiodarone should have baseline thyroid function tests before starting amiodarone therapy
    • Type 1 amiodarone-induced hyperthyroidism (Jod-Basedow phenomenon) causes an increased production of thyroid hormones due to the iodine portion of amiodarone
    • Type 2 amiodarone-induced hyperthyroidism resembles a destructive thyroiditis, where increased amounts of thyroid hormone are released

IV contrast agents for CT scans

  • Excess iodine in the contrast material used for CT scans may cause an increased production of thyroid hormone.

Hyperthyroidism Prognosis

Hyperthyroidism is typically treatable and rarely fatal. However, complications can arise with untreated hyperthyroidism. Untreated hyperthyroidism may have the following complications:

  • Dehydration from excess heat, excess sweating, and diarrhea
  • Systolic hypertension
  • Bone loss with high blood calcium fractures
  • Abnormalities of heart rhythm

Complications may also arise from side effects of therapies, including radioactive iodine, surgery, and thyroid hormone replacement therapy.

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Read What Your Physician is Reading on Medscape

Hyperthyroidism »

Thyrotoxicosis is the hypermetabolic condition associated with elevated levels of free thyroxine (FT4), free triiodothyronine (FT3), or both.

Read More on Medscape Reference »


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