Image Collection: Diseases of Pigment

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12. Picture of Multiple Lentigines Syndrome (Face)

Picture of Multiple Lentigines Syndrome (Face)
Image Source: Color Atlas & Synopsis of Pediatric Dermatology Kay Shou-Mei Kane, Jen Bissonette Ryder, Richard Allen Johnson, Howard P. Baden, Alexander Stratigos Copyright 2002 by The McGraw-Hill Companies. All rights reserved.
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Noonan syndrome, formerly known as LEOPARD syndrome, is a genetic disorder characterized by:

  • Lentigines, or dark spots on the neck and head
  • Elecrocardiogram irregularities
  • Ocular hyperteleorism (wide space between the eyes)
  • Pulmonary stenosis
  • Abnormal genitals
  • Retarded growth
  • Deafness (sensorineural type)

The condition is inherited in an autosomal dominant fashion. Mutations in the gene for protein-tyrosine phosphatase, nonreceptor-type 11 (PTPN11) cause the condition.

Image Source: Color Atlas & Synopsis of Pediatric Dermatology Kay Shou-Mei Kane, Jen Bissonette Ryder, Richard Allen Johnson, Howard P. Baden, Alexander Stratigos Copyright 2002 by The McGraw-Hill Companies. All rights reserved.

Text Reference: Genetics Home Reference: "Noonan Syndrome with Multiple Lentigines"

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