Xanthomas are papules or nodules of the skin or mucous membranes that contain lipids. The appearance of xanthomas during childhood should prompt a thorough search for underlying systemic disease. The yellowish papules seen in here are a form of planar xanthoma. These may occur on any part of the body and may be an indicator of a hereditary lipoproteinemia, diabetes mellitus, or liver disease. Multiple myeloma and histiocytosis X are less common etiologies. The patient pictured here has biliary cirrhosis.