Inability to Urinate (cont.)
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Two types of medications available for treating enlarged prostate in men are also generally used in the treatment of urinary retention.
The first class of medications (called alpha receptor blockers) work by relaxing the muscles at the neck of the bladder, thus reducing the obstruction to the flow of urine. The common medications in this class are terazosin (Hytrin), tamsulosin (Flomax), doxazosin (Cardura), and alfuzosin (Uroxatral). These medications are generally used for treating long-standing obstructive symptoms due to enlarged prostate, but they may have a role in treating acute obstruction. Some studies have suggested that early initiation of these medications may improve urinary problems upon the removal of a urinary catheter.
The second class of medications for the treatment of prostate enlargement (called 5-alpha reductase inhibitors) work by shrinking the size of the prostate gland. They inhibit locally (in the prostate) the conversion of testosterone to one of its metabolites which is thought to play a role in increasing prostate size. Finasteride (Proscar) and dutasteride (Avodart) are the two commonly used medications of this type. They are also primarily used to treat long-standing urinary problems due to prostate enlargement. Unlike the other drug class, they play no role in treating acute urinary obstruction because their action of reducing the prostate size may take weeks to months.
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