Incontinentia Pigmenti (cont.)Medical Author:
Andrew A. Dahl, MD, FACS
Andrew A. Dahl, MD, FACSAndrew A. Dahl, MD, is a board-certified ophthalmologist. Dr. Dahl's educational background includes a BA with Honors and Distinction from Wesleyan University, Middletown, CT, and an MD from Cornell University, where he was selected for Alpha Omega Alpha, the national medical honor society. He had an internal medical internship at the New York Hospital/Cornell Medical Center. Medical Editor:
Melissa Conrad Stöppler, MD, Chief Medical Editor
Melissa Conrad Stöppler, MD, Chief Medical EditorMelissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology. IN THIS ARTICLE
Incontinentia Pigmenti CausesIncontinentia pigmenti usually occurs in females, as it is an X-linked (inherited from the mother on the X, or female, chromosome) dominantly inherited disease that is lethal in males. This genetic disease is carried on the X chromosome. Girls have two X chromosomes, and the abnormal gene on one X chromosome is "balanced" by the normal gene on the other X chromosome. Males, who have only one X chromosome, do not generally survive until birth if their X chromosome has the abnormal gene for IP because they lack the balancing second X chromosome that females have. Unless a passed-on gene spontaneously mutates, all mothers of girls with IP also have IP, although the extent and degree of organ involvement is extremely variable. Next Page: Must Read Articles Related to Incontinentia Pigmenti
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Incontinentia Pigmenti »
Incontinentia pigmenti (IP) is an X-linked dominant neurocutaneous syndrome with cutaneous, neurologic, ophthalmologic, and dental manifestations.
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