isotretinoin, Sotret, Claravis, Amnesteem, (Accutane is no longer available) Glossary of Terms

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Absorption: Uptake. For example, intestinal absorption is the uptake of food (or other substances) from the digestive tract.

Achromycin: See: Tetracycline.

Acne: Localized skin inflammation as a result of overactivity of the oil glands at the base of hair follicles. Acne happens when oil (sebaceous) glands come to life around puberty, when these glands are stimulated by male hormones that are produced in the adrenal glands of both boys and girls.
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Birth control: Birth control is the use of any practices, methods, or devices to prevent pregnancy from occurring in a sexually active woman. Also referred to as family planning, pregnancy prevention, fertility control, or contraception; birth control methods are designed either to prevent fertilization of an egg or implantation of a fertilized egg in the uterus.
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Brain: The portion of the central nervous system that is located within the skull. It functions as a primary receiver, organizer, and distributor of information for the body. It has a right half and a left half, each of which is called a hemisphere.

Brain swelling: See: Cerebral edema.

Cholesterol: The most common type of steroid in the body. Cholesterol has a reputation for being associated with an increased risk for heart and blood vessel disease. However, cholesterol is essential to the formation of bile acids, vitamin D, progesterone, estrogens (estradiol, estrone, estriol), androgens (androsterone, testosterone), mineralocorticoid hormones (aldosterone, corticosterone), and glucocorticoid hormones (cortisol). Cholesterol is also necessary to the normal permeability and function of the membranes that surround cells. A diet high in saturated fats tends to increase blood cholesterol levels, whereas a diet high in unsaturated fats tends to lower blood cholesterol levels. Although some cholesterol is obtained from the diet, most cholesterol is made in the liver and other tissues. The treatment of elevated cholesterol involves not only diet but also weight loss, regular exercise, and medications. After the age of 20, cholesterol testing is recommended every 5 years.

Depression: An illness that involves the body, mood, and thoughts and that affects the way a person eats, sleeps, feels about himself or herself, and thinks about things. Depression is not the same as a passing blue mood. It is not a sign of personal weakness or a condition that can be wished away. People with depression cannot merely 'pull themselves together' and get better. Without treatment, symptoms can last for weeks, months, or years. Appropriate treatment, however, can help most people with depression. The signs and symptoms of depression include loss of interest in activities that were once interesting or enjoyable, including sex; loss of appetite, with weight loss, or overeating, with weight gain; loss of emotional expression (flat affect); a persistently sad, anxious, or empty mood; feelings of hopelessness, pessimism, guilt, worthlessness, or helplessness; social withdrawal; unusual fatigue, low energy level, a feeling of being slowed down; sleep disturbance and insomnia, early-morning awakening or oversleeping; trouble concentrating, remembering, or making decisions; unusual restlessness or irritability; persistent physical problems such as headaches, digestive disorders, or chronic pain that do not respond to treatment, and thoughts of death or suicide or suicide attempts. The principal types of depression are called major depression, dysthymia, and bipolar disease (manic-depressive disease).

Dry mouth: The condition of not having enough saliva to keep the mouth wet. This is due to inadequate function of the salivary glands. Everyone has dry mouth once in a while when they are nervous, upset or under stress. But if someone has a dry mouth most all of the time, it can be uncomfortable and lead to serious health problems.
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Dry skin: Abnormally dry skin. Can be caused by a dry climate, winter weather, deficiency of vitamin A, systemic illness, overexposure to sunlight, or medication. The skin loses moisture. It may crack and peel. Or it may become irritated, inflamed, and itch. Bathing frequently, especially with soaps, can contribute to dry skin.
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Epidermal: Pertaining to the epidermis, the outermost layer of the skin.

Epistaxis: Medical term for nosebleed. The nose is a part of the body that is very rich in blood vessels (vascular) and is situated in a vulnerable position on the face. As a result, any trauma to the face can cause bleeding which may be profuse. Nosebleeds can occur spontaneously when the nasal membranes dry out, crust, and crack, as is common in dry climates, or during the winter months when the air is dry and warm from household heaters. People are more susceptible if they are taking medications which prevent normal blood clotting (Coumadin, warfarin, aspirin, or any anti-inflammatory medication). Other predisposing factors include infection, trauma, allergic and non-allergic rhinitis, hypertension, alcohol abuse, and inherited bleeding problems. "Epistaxis" is a Greek word meaning "a dripping," especially of blood from the nose.

Erythema: Redness of the skin that results from capillary congestion. Erythema can occur with inflammation, as in sunburn and allergic reactions to drugs.

Erythema multiforme: See: Stevens-Johnson syndrome.

Fetus: An unborn offspring, from the embryo stage (the end of the eighth week after conception, when the major structures have formed) until birth.

Food and Drug Administration: An agency within the US Public Health Service that provides a number of health-related services. Abbreviated FDA. The FDA's services include inspecting food and food-processing facilities to ensure wholesomeness and safety; scrutinizing food and drugs for pets and farm animals; ensuring that cosmetics will not cause harm; monitoring the health of the nation's blood supply; ensuring that medicines, medical devices, and biologicals (such as insulin and vaccines) are safe and effective; and testing radiation-emitting products such as microwave ovens to protect the public. The FDA also oversees health and safety labeling of these products. All new prescription and over-the-counter drugs are subject to FDA approval. The FDA must determine that a new drug produces the benefits it's supposed to produce, without causing side effects that would outweigh the benefits. It does so by looking at the results of clinical trials done outside the FDA. When serious adverse effects from a medication are reported, the FDA has the power to force the manufacturer to make changes in the drug, change its safety labeling or marketing practices, or remove the medication from the market.

Generic: 1. The chemical name of a drug. 2. A term referring to the chemical makeup of a drug rather than to the advertised brand name under which the drug may be sold. 3.A term referring to any drug marketed under its chemical name without advertising.

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Headache: A pain in the head with the pain being above the eyes or the ears, behind the head (occipital), or in the back of the upper neck. Headache, like chest pain or back ache, has many causes.
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Hepatitis: Inflammation of the liver, irrespective of the cause. Hepatitis is caused by a number of conditions, including drug toxicity, immune diseases, and viruses.

Hypertension: High blood pressure, defined as a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140 with a diastolic pressure above 90.
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Inflammation: A localized reaction that produces redness, warmth, swelling, and pain as a result of infection, irritation, or injury. Inflammation can be external or internal.

Intracranial: Within the cranium, the bony dome that houses and protects the brain.
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Itching: An uncomfortable sensation in the skin that feels as if something is crawling on the skin and makes the person want to scratch the affected area. Itching is medically known as pruritis; something that is itchy is pruritic.

Joint: The area where two bones are attached for the purpose of permitting body parts to move. A joint is usually formed of fibrous connective tissue and cartilage. Joints are grouped according to their type of motion: ball-and-socket joint; hinge joint; condyloid joint, which permits all forms of angular movement except axial rotation; pivot joint; gliding joint; or saddle joint. Joints can move in only four ways: gliding, in which one bony surface glides on another, without angular or rotatory movement; angular, a movement that occurs only between long bones, increasing or decreasing the angle between the bones; circumduction, which occurs in joints composed of the head of a bone and an articular cavity, with the long bone describing a series of circles and the whole forming a cone; and rotation, in which a bone moves about a central axis without moving from this axis. Also known as articulation and arthrosis.

Mouth: 1. The upper opening of the digestive tract, beginning with the lips and containing the teeth, gums, and tongue. Foodstuffs are broken down mechanically in the mouth by chewing and saliva is added as a lubricant. Saliva contains amylase, an enzyme that digests starch. 2. Any opening or aperture in the body. The mouth in both senses of the word is also called the os, the Latin word for an opening, or mouth. The o in os is pronounced as in hope. The genitive form of os is oris from which comes the word oral.

Nausea: Stomach queasiness, the urge to vomit. Nausea can be brought on by many causes, including systemic illnesses (such as influenza), medications, pain, and inner ear disease.

Nose: The external midline projection from the face. The purpose of the nose is to warm, clean, and humidify the air that a person breathes. In addition, it helps a person to smell and taste. The nose is divided into two passageways by a partition called the septum. Opening to these passageways are the nostrils. Bony projections, called turbinates, protrude into each breathing passage; they help to increase the surface area of the inside of the nose. There are three turbinates on each side of the nose (the inferior, middle, and superior turbinates). The sinuses are four paired air-filled chambers that empty into the nasal cavity.

Nursing: 1) Profession concerned with the provision of services essential to the maintenance and restoration of health by attending the needs of sick persons. 2) Feeding a infant at the breast.

Pregnancy: The state of carrying a developing embryo or fetus within the female body. This condition can be indicated by positive results on an over-the-counter urine test, and confirmed through a blood test, ultrasound, detection of fetal heartbeat, or an X-ray. Pregnancy lasts for about nine months, measured from the date of the woman's last menstrual period (LMP). It is conventionally divided into three trimesters, each roughly three months long.
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Prescription: A physician's order for the preparation and administration of a drug or device for a patient. A prescription has several parts. They include the superscription or heading with the symbol "R" or "Rx", which stands for the word recipe (meaning, in Latin, to take); the inscription, which contains the names and quantities of the ingredients; the subscription or directions for compounding the drug; and the signature which is often preceded by the sign "s" standing for signa (Latin for mark), giving the directions to be marked on the container.

Pseudotumor cerebri: Increased pressure within the brain in the absence of a tumor. Pseudotumor cerebri can cause headache, ringing in the ears, double vision, loss of visual accuracy, and even complete blindness. It is most common in obese woman of childbearing age. Although its cause is usually not known, pseudotumor cerebri is sometimes linked to use of tetracycline, nalidixic acid, nitrofurantoin, phenytoin, lithium, or amiodarone, or overuse of vitamin A. Diagnosis is made via brain imaging and lumbar puncture. Drugs to reduce cerebrospinal fluid production or hyperosmotic drugs may be used to reduce fluid buildup. Excess cerebrospinal fluid may be removed with repeated spinal taps, shunting, or a type of surgery called optic nerve sheath fenestration that allows the excess fluid to escape. Steroids may be prescribed to reduce swelling of brain tissue. Also known as benign intracranial hypertension, idiopathic intracranial hypertension (IIH).

Psychiatric: Pertaining to or within the purview of psychiatry, the medical specialty concerned with the prevention, diagnosis, and treatment of mental illness.
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Remission: Disappearance of the signs and symptoms of cancer or other disease. A remission can be temporary or permanent.

Sebum: An oily secretion of the sebaceous gland which helps to preserve the flexibility of the hair.

Sensitivity: 1. In psychology, the quality of being sensitive. As, for example, sensitivity training, training in small groups to develop a sensitive awareness and understanding of oneself and of ones relationships with others. 2. In disease epidemiology, the ability of a system to detect epidemics and other changes in disease occurrence. 3. In screening for a disease, the proportion of persons with the disease who are correctly identified by a screening test. 4. In the definition of a disease, the proportion of persons with the disease who are correctly identified by defined criteria.

Stevens-Johnson syndrome: A serious systemic (bodywide) allergic reaction with a characteristic rash involving the skin and mucous membranes, including the buccal mucosa (inside of the mouth), conjunctiva, and genital areas. Abbreviated SJS. The disease is due to a hypersensitive (allergic) reaction to one of a number of immunologic stimuli including drugs and infectious agents. Complications can include hepatitis, nephritis, gastrointestinal bleeding, pneumonia, arthritis, arthralgia, fever, and myalgia. The diagnosis of SJS is usually made when the characteristic rash appears 1 to 3 weeks after exposure to a known stimulus and it cannot be explained by another diagnosis. The treatment depends, in part, on the suspected precipitating cause. Also known as erythema multiforme.

Substance: 1. Material with particular features.
2. The material that makes up an organ or structure. Also known in medicine as the substantia.

Suicidal: Pertaining to suicide. the taking of ones own life. As in a suicidal gesture, suicidal thought, or suicidal act. An "online lifeline for suicidal undergrads" may help prevent college students from committing suicide.

Syndrome: A combination of symptoms and signs that together represent a disease process.

Tetracycline: A family of broad-spectrum antibiotics effective against a remarkably wide variety of organisms. Bacteria susceptible to tetracycline include H. flu (Haemophilus influenzae), strep (Streptococcus pneumoniae), Mycoplasma pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, and Neisseria gonorrhoeae (the cause of gonorrhea). Tetracycline is also used to treat nongonococcal urethritis (due to Ureaplasma), Rocky mountain spotted fever, typhus, chancroid, cholera, brucellosis, anthrax, and syphilis. It is used in combination with other medications to treat Helicobacter pylori, the bacteria associated with ulcers of the stomach and duodenum.
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Therapy: The treatment of disease. Therapy is synonymous with treatment.

Topical: Pertaining to a particular surface area. For example, a topical agent is applied to a certain area of the skin and is intended to affect only the area to which it is applied. Whether its effects are indeed limited to that area depends on whether the agent stays where it is put or is absorbed into the bloodstream. Cortisone creams are topical 'medications.

Triglycerides: The major form of fat stored by the body. A triglyceride consists of three molecules of fatty acid combined with a molecule of the alcohol glycerol. Triglycerides serve as the backbone of many types of lipids (fats). Triglycerides come from the food we eat as well as from being produced by the body.
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Vitamin A: Vitamin A is retinol. Carotene compounds (found, for example, in egg yolk, butter and cream) are gradually converted by the body to vitamin A (retinol). A form of vitamin A called retinal is responsible for transmitting light sensation in the retina of the eye.
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