Juvenile Rheumatoid Arthritis (cont.)
What Are Juvenile Idiopathic Arthritis (JIA) Causes?
The cause of juvenile idiopathic arthritis is unknown. Like adult-type RA and many other related diseases, JIA is an autoimmune disease. This means that the body's immune system mistakenly attacks the tissues it is supposed to protect.
- The chronic inflammation of the synovium (the fluid-producing tissue that surrounds the joints) is linked to greater-than-normal activity of the immune system.
- Normally, the immune system fights "assaults" by "invaders" such as infections or blood or tissue from another person.
- The immune system produces specialized cells and proteins, which are released into the bloodstream to fight off the "invaders." One important type of immune protein is called an antibody.
- In autoimmune diseases such as JIA, the cells and antibodies of the immune system attack the body's own tissues. In the case of arthritis, the attack is directed against the synovium, which becomes inflamed.
- The inflammation causes the synovium to thicken and grow abnormally. As the synovium expands outside of the joint, it presses on and eventually damages the bone and cartilage of the joint and the surrounding tissues such as ligaments and tendons.
- We do not know what causes the inappropriate autoimmune response. Because the cause has not yet been discovered, we use the term "idiopathic" which means "of unknown cause."
- Emotional factors and diet do not appear to be risk factors for JIA.
- According to statistics from the Arthritis Foundation, there are at least 300,000 children in the U.S. with JIA.
Medically Reviewed by a Doctor on 5/11/2016
Must Read Articles Related to Juvenile Rheumatoid Arthritis
Iritis, or anterior uveitis, is an inflammation on the front part of the eye called the iris, which is the colored part of the eye that opens and closes the pup...learn more >>
Rheumatoid arthritis (often called RA) is a chronic (long-standing) disease that damages the joints of the body. Symptoms and signs of rheumatoid arthritis incl...learn more >>
Understanding Rheumatoid Arthritis Medications
Rheumatoid arthritis (RA) is a chronic disease that causes joint inflammation. Medications for RA include salicylates, NSAIDs, COX-2 inhibitors, DMARDs, biologi...learn more >>
Patient Comments & Reviews
The eMedicineHealth doctors ask about Juvenile Idiopathic Arthritis (Juvenile Rheumatoid Arthritis):