Kidney Transplant Glossary of Terms

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Abdomen: The belly, that part of the body that contains all of the structures between the chest and the pelvis. The abdomen is separated anatomically from the chest by the diaphragm, the powerful muscle spanning the body cavity below the lungs.
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Abdominal: Relating to the abdomen, the belly, that part of the body that contains all of the structures between the chest and the pelvis. The abdomen is separated anatomically from the chest by the diaphragm, the powerful muscle spanning the body cavity below the lungs.
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Abdominal pain: Pain in the belly (the abdomen). Abdominal pain can come from conditions affecting a variety of organs. The abdomen is an anatomical area that is bounded by the lower margin of the ribs above, the pelvic bone (pubic ramus) below, and the flanks on each side. Although abdominal pain can arise from the tissues of the abdominal wall that surround the abdominal cavity (the skin and abdominal wall muscles), the term abdominal pain generally is used to describe pain originating from organs within the abdominal cavity (from beneath the skin and muscles). These organs include the stomach, small intestine, colon, liver, gallbladder, and pancreas.
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Abnormal: Not normal. Deviating from the usual structure, position, condition, or behavior. In referring to a growth, abnormal may mean that it is cancerous or premalignant (likely to become cancer).

Absorption: Uptake. In the biomedical sciences, absorption has diverse specific meanings.
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Acne: Localized skin inflammation as a result of overactivity of the oil glands at the base of hair follicles. Acne happens when oil (sebaceous) glands come to life around puberty, when these glands are stimulated by male hormones that are produced in the adrenal glands of both boys and girls.
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Acquired: Anything that is not present at birth but develops some time later. In medicine, the word "acquired" implies "new" or "added." An acquired condition is "new" in the sense that it is not genetic (inherited) and "added" in the sense that was not present at birth.
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Acute: Of abrupt onset, in reference to a disease. Acute often also connotes an illness that is of short duration, rapidly progressive, and in need of urgent care.
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Acute kidney failure: See: Acute renal failure.

Acute tubular necrosis: A severe form of acute renal failure that develops in people with severe illnesses (such as sepsis) or with very low blood pressure. Patients may need dialysis. Kidney function often improves if the underlying disease is successfully treated. Abbreviated ATN.

Amyloidosis: A disorder that results from the abnormal deposition of a particular protein, called amyloid, in various tissues of the body. Amyloid protein can be deposited in a localized area, and not be harmful, or in can cause serious changes in virtually any organ of the body.
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Anemia: The condition of having less than the normal number of red blood cells or less than the normal quantity of hemoglobin in the blood. The oxygen-carrying capacity of the blood is, therefore, decreased.
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Arms: An appendage in anatomy and in clinical trials. See: Arm.

Arteriogram: An x-ray of blood vessels, which becomes visible after an injection of contrast solution into the circulation that appears on the x-ray film.

Artery: A vessel that carries blood high in oxygen content away from the heart to the farthest reaches of the body. Since blood in arteries is usually full of oxygen, the hemoglobin in the red blood cells is oxygenated. The resultant form of hemoglobin (oxyhemoglobin) is what makes arterial blood look bright red.
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Arthritis: Inflammation of a joint. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis. (see osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout, pseudogout).

Avascular necrosis: (AVN) A condition in which the poor blood supply to an area of bone leads to bone death. The head of the femur is often the site of AVN. Also called avascular necrosis and osteonecrosis.

Basal cell carcinoma: The most common type of skin cancer, a disease in which the cancer cells resemble the basal cells of the epidermis, the outer layer of the skin.
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Belly: That part of the body that contains all of the structures between the chest and the pelvis. Also called the abdomen.
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Bladder: Any pouch or other flexible enclosure that can hold liquids or gases but usually refers to the hollow organ in the lower abdomen that stores urine -- the urinary bladder. The kidneys filter waste from the blood and produce urine, which enters the bladder through two tubes called ureters. Urine leaves the bladder through another tube, the urethra. In women, the urethra is a short tube that opens just in front of the vagina. In men, it is longer, passing through the prostate gland and then the penis. Infection of the bladder is called cystitis.

Blood clot: Blood that has been converted from a liquid to a solid state. Also called a thrombus.
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Blood pressure: The blood pressure is the pressure of the blood within the arteries. It is produced primarily by the contraction of the heart muscle. It's measurement is recorded by two numbers. The first (systolic pressure) is measured after the heart contracts and is highest. The second (diastolic pressure) is measured before the heart contracts and lowest. A blood pressure cuff is used to measure the pressure. Elevation of blood pressure is called "hypertension".

Blood sugar: Blood glucose. See also: High blood sugar; Low blood sugar.

Bone marrow: The soft blood-forming tissue that fills the cavities of bones and contains fat and immature and mature blood cells, including white blood cells, red blood cells, and platelets. Diseases or drugs that affect the bone marrow can affect the total counts of these cells.

Breathing: The process of respiration, during which air is inhaled into the lungs through the mouth or nose due to muscle contraction, and then exhaled due to muscle relaxation.

Calcium: A mineral found mainly in the hard part of bones, where it is stored. Calcium is added to bones by cells called osteoblasts and is removed from bones by cells called osteoclasts. Calcium is essential for healthy bones. It is also important for muscle contraction, heart action, nervous system maintenance, and normal blood clotting. Food sources of calcium include dairy foods, some leafy green vegetables such as broccoli and collards, canned salmon, clams, oysters, calcium-fortified foods, and tofu. According to the National Academy of Sciences, adequate intake of calcium is 1,200 milligrams a day (four glasses of milk) for men and women 51 and older, 1,000 milligrams a day for adults 19 through 50, and 1,300 milligrams a day for children 9 through 18. The upper limit for calcium intake is 2.5 grams daily.

Cancer: An abnormal growth of cells which tend to proliferate in an uncontrolled way and, in some cases, to metastasize (spread).
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Carcinoma: Cancer that begins in the skin or in tissues that line or cover body organs. For example, carcinoma can arise in the breast, colon, liver, lung, prostate, and stomach.

Carcinoma in situ: Cancer that involves only the place in which it began and that has not spread. Carcinoma in situ is an early-stage tumor.
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Cell: The basic structural and functional unit in people and all living things. Each cell is a small container of chemicals and water wrapped in a membrane.
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Cervix: The cervix is the lower, narrow part of the uterus (womb). The uterus, a hollow, pear-shaped organ, is located in a woman's lower abdomen, between the bladder and the rectum. The cervix forms a canal that opens into the vagina, which leads to the outside of the body.

Chemotherapy: 1. In the original sense, a chemical that binds to and specifically kills microbes or tumor cells. The term chemotherapy was coined in this regard by Paul Ehrlich (1854-1915).
2. In oncology, drug therapy for cancer. Also called "chemo" for short.
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Chest: The area of the body located between the neck and the abdomen. The chest contains the lungs, the heart and part of the aorta. The walls of the chest are supported by the dorsal vertebrae, the ribs, and the sternum.
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Cholesterol: The most common type of steroid in the body, cholesterol has gotten something of a bad name. However, cholesterol is a critically important molecule.
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Chronic: This important term in medicine comes from the Greek chronos, time and means lasting a long time.
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Chronic kidney failure: See: Chronic renal failure.

Chronic renal failure: Slow progressive loss of kidney function over the span of years, resulting in permanent kidney failure. Chronic kidney disease is common and may go undiagnosed until the process is far advanced and renal failure is on the horizon. People with permanent kidney failure need dialysis or a transplanted kidney to do the work of their failed kidneys.
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Circulatory: Having to do with the circulation, the movement of fluid in a regular or circuitous course. Although the adjective "circulatory" need not necessarily refer to the circulation of the blood, for all practical purposes today it does. A circulatory problem is taken usually to be a problem with the blood circulation, for example with heart failure.

Circulatory system: The system that moves blood throughout the body. The circulatory system is composed of the heart, arteries, capillaries, and veins. This remarkable system transports oxygenated blood from the lungs and heart throughout the body via the arteries. The blood goes through the capillaries which are situated between the arteries and veins. And the blood that has been depleted of oxygen by the body is then returned to the lungs and heart via the veins.

Complication: In medicine, an additional problem that arises following a procedure, treatment or illness and is secondary to it. A complication complicates the situation.

Congenital: Present at birth. A condition that is congenital is one that is present at birth. There are numerous uses of "congenital" in medicine. There are, for example, congenital abnormalities. (For more examples, see below.)
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Creatinine: A chemical waste molecule that is generated from muscle metabolism. Creatinine is produced from creatine, a molecule of major importance for energy production in muscles. Approximately 2% of the body's creatine is converted to creatinine every day. Creatinine is transported through the bloodstream to the kidneys. The kidneys filter out most of the creatinine and dispose of it in the urine.
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Cure: 1. To heal, to make well, to restore to good health. Cures are easy to claim and, all too often, difficult to confirm.
2. A time without recurrence of a disease so that the risk of recurrence is small, as in the 5-year cure rate for malignant melanoma.
3. Particularly in the past, a course of treatment. For example, take a cure at a spa.
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Cystinosis: A genetic disease characterized by the widespread deposition of the amino acid cystine in cells due to a defect in cystine transport. (Cystine normally forms after protein degradation and is transported from structures called lysosomes into the cytoplasm. In cystinosis, cystine accumulates in the lysoosmes and eventually forms crystals throughout the body. Cystinosis is therefore a lysosomal storage disease.)
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Dehydration: Excessive loss of body water. Diseases of the gastrointestinal tract that cause vomiting or diarrhea may, for example, lead to dehydration. There are a number of other causes of dehydration including heat exposure, prolonged vigorous exercise (e.g., in a marathon), kidney disease, and medications (diuretics).
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Diabetes: Refers to diabetes mellitus or, less often, to diabetes insipidus. Diabetes mellitus and diabetes insipidus share the name "diabetes" because they are both conditions characterized by excessive urination (polyuria).
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Diagnosis: 1 The nature of a disease; the identification of an illness. 2 A conclusion or decision reached by diagnosis. The diagnosis is rabies. 3 The identification of any problem. The diagnosis was a plugged IV.
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Dialysis: The process of cleansing the blood by passing it through a special machine. Dialysis is necessary when the kidneys are not able to filter the blood. Dialysis allows patients with kidney failure a chance to live productive lives. There are two types of dialysis: hemodialysis and peritoneal dialysis. Each type of dialysis has advantages and disadvantages. Patients can often choose the type of long term dialysis that best matches their needs.

Donor: The giver of a tissue or organ, for example, of blood or a kidney.

Edema: The swelling of soft tissues as a result of excess water accumulation.
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Electrolyte: An electrolyte is a substance that will dissociate into ions in solution and acquire the capacity to conduct electricity. The electrolytes include sodium, potassium, chloride, calcium and phosphate. Informally, called lytes. (The clue to the word electrolyte is in the lyte which comes from the Greek lytos meaning that may be dissolved.)

Emergency department: The department of a hospital responsible for the provision of medical and surgical care to patients arriving at the hospital in need of immediate care. Emergency department personnel may also respond to certain situations within the hospital such cardiac arrests.
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End-stage renal disease: ESRD. Chronic irreversible renal failure.

ESRD: End-stage renal disease.

Essential: 1. Something that cannot be done without.
2. Required in the diet, because the body cannot make it. As in an essential amino acid or an essential fatty acid.
3. Idiopathic. As in essential hypertension. "Essential" is a hallowed term meaning "We don't know the cause."

Fatigue: A condition characterized by a lessened capacity for work and reduced efficiency of accomplishment, usually accompanied by a feeling of weariness and tiredness. Fatigue can be acute and come on suddenly or chronic and persist.
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Fever: Although a fever technically is any body temperature above the normal of 98.6 degrees F. (37 degrees C.), in practice a person is usually not considered to have a significant fever until the temperature is above 100.4 degrees F (38 degrees C.).
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Fracture: A break in bone or cartilage. Although usually the result of trauma, a fracture can be caused by an acquired disease of bone such as osteoporosis or by abnormal formation of bone in a disease such as osteogenesis imperfecta ("brittle bone disease"). Fractures are classified according to their character and location as, for example, a greenstick fracture of the radius.
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Glomerular: Pertaining to the glomerulus, a tiny structure in the kidney that filters the blood to form urine.

Glomeruli: The plural of glomerulus.

Gout: Condition characterized by abnormally elevated levels of uric acid in the blood, recurring attacks of joint inflammation (arthritis), deposits of hard lumps of uric acid in and around the joints, and decreased kidney function and kidney stones. Uric acid is a breakdown product of purines, that are part of many foods we eat. The tendency to develop gout and elevated blood uric acid level (hyperuricemia) is often inherited and can be promoted by obesity, weight gain, alcohol intake, high blood pressure, abnormal kidney function, and drugs. The most reliable diagnostic test for gout is the identification of crystals in joints, body fluids and tissues.

Graft: Healthy skin, bone, or other tissue taken from one part of the body to replace diseased or injured tissue removed from another part of the body.
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Heart: The muscle that pumps blood received from veins into arteries throughout the body. It is positioned in the chest behind the sternum (breastbone; in front of the trachea, esophagus, and aorta; and above the diaphragm muscle that separates the chest and abdominal cavities. The normal heart is about the size of a closed fist, and weighs about 10.5 ounces. It is cone-shaped, with the point of the cone pointing down to the left. Two-thirds of the heart lies in the left side of the chest with the balance in the right chest.
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Heart attack: The death of heart muscle due to the loss of blood supply. The loss of blood supply is usually caused by a complete blockage of a coronary artery, one of the arteries that supplies blood to the heart muscle. Death of the heart muscle, in turn, causes chest pain and electrical instability of the heart muscle tissue.
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Heart disease: Any disorder that affects the heart. Sometimes the term "heart disease" is used narrowly and incorrectly as a synonym for coronary artery disease. Heart disease is synonymous with cardiac disease but not with cardiovascular disease which is any disease of the heart or blood vessels. Among the many types of heart disease, see, for example: Angina; Arrhythmia; Congenital heart disease; Coronary artery disease (CAD); Dilated cardiomyopathy; Heart attack (myocardial infarction); Heart failure; Hypertrophic cardiomyopathy; Mitral regurgitation; Mitral valve prolapse; and Pulmonary stenosis.

Heart rate: The number of heart beats per unit time, usually per minute. The heart rate is based on the number of contractions of the ventricles (the lower chambers of the heart). The heart rate may be too fast (tachycardia) or too slow (bradycardia). The pulse is bulge of an artery from the wave of blood coursing through the blood vessel as a result of the heart beat. The pulse is often taken at the wrist to estimate the heart rate.

Hemolytic: Referring to hemolysis, the destruction of red blood cells which leads to the release of hemoglobin from within the red blood cells into the blood plasma.
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Hemolytic uremic syndrome: A condition characterized by the breakup of red blood cells (hemolysis) and kidney failure. There is clumping of platelets (the blood cells responsible for clotting) within the kidney's small blood vessels with resultant ischemia (reduced blood flow) leading to the kidney failure. The partial blockage of the blood vessels also leads to the destruction of red blood cells (hemolysis). Platelets are also decreased which can cause bleeding problems.
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Hepatitis: Inflammation of the liver from any cause.
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Hepatitis C: Inflammation of the liver due to the hepatitis C virus (HCV), which is usually spread by blood transfusion, hemodialysis, and needle sticks. HCV causes most transfusion-associated hepatitis, and the damage it does to the liver can lead to cirrhosis and cancer. Transmission of the virus by sexual contact is rare. At least half of HCV patients develop chronic hepatitis C infection. Diagnosis is by blood test. Treatment is via anti-viral drugs. Chronic hepatitis C may be treated with interferon, sometimes in combination with anti-virals. There is no vaccine for hepatitis C. Previously known as non-A, non-B hepatitis.

Hepatobiliary: Having to do with the liver plus the gallbladder, bile ducts, or bile. For example, MRI (magnetic resonance imaging) can be applied to the hepatobiliary system.
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Heroin: Semisynthetic drug derived from morphine. Discovered in 1874, it was introduced commercially in 1898 by the Bayer company in Germany. The name heroin was coined from the German heroisch meaning heroic, strong. Heroin is stronger (more potent) than morphine.

High blood pressure: Also known as hypertension, high blood pressure is, by definition, a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140 with a diastolic pressure above 90.
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High blood sugar: An elevated level of the sugar glucose in the blood. Also called hyperglycemia.
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HIV: Acronym for the Human Immunodeficiency Virus, the cause of AIDS (acquired immunodeficiency syndrome). HIV has also been called the human lymphotropic virus type III, the lymphadenopathy-associated virus and the lymphadenopathy virus. No matter what name is applied, it is a retrovirus. (A retrovirus has an RNA genome and a reverse transcriptase enzyme. Using the reverse transcriptase, the virus uses its RNA as a template for making complementary DNA which can integrate into the DNA of the host organism).
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Hypertension: High blood pressure, defined as a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140 with a diastolic pressure above 90.
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Immune: Protected against infection. The Latin immunis means free, exempt.

Immune system: A complex system that is responsible for distinguishing us from everything foreign to us, and for protecting us against infections and foreign substances. The immune system works to seek and kill invaders.
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Immunosuppression: Suppression of the immune system. Immunosuppression may result from certain diseases such as AIDS or lymphoma or from certain drugs such as some of those used to treat cancer. Immunosuppression may also be deliberately induced with drugs, as in preparation for bone marrow or other organ transplantation to prevent the rejection of the transplant.

In situ: In the normal location. An "in situ" tumor is one that is confined to its site of origin and has not invaded neighboring tissue or gone elsewhere in the body.
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Infection: The growth of a parasitic organism within the body. (A parasitic organism is one that lives on or in another organism and draws its nourishment therefrom.) A person with an infection has another organism (a "germ") growing within him, drawing its nourishment from the person.
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Inflammation: A basic way in which the body reacts to infection, irritation or other injury, the key feature being redness, warmth, swelling and pain. Inflammation is now recognized as a type of nonspecific immune response.
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Injury: Harm or hurt. The term "injury" may be applied in medicine to damage inflicted upon oneself as in a hamstring injury or by an external agent on as in a cold injury. The injury may be accidental or deliberate, as with a needlestick injury. The term "injury" may be synonymous (depending on the context) with a wound or with trauma.

Interstitial: Pertaining to being between things, especially between things that are normally closely spaced.
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Itching: An uncomfortable sensation in the skin that feels as if something is crawling on the skin or in the skin, and makes the person want to scratch the affected area.
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Kaposi sarcoma: A relatively rare type of skin malignancy that tends to afflict elderly people or, especially, those with an abnormal immune system as in AIDS. Kaposi sarcoma is a highly vascular ("angioblastic") tumor of the skin characterized by soft purplish plaques and papules that form nodules which typically start on the feet and ankles and then slowly spread across the skin of the legs, hands and arms. In AIDS patients, these tumors can also develop internally and cause severe internal bleeding.
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Kidney: One of a pair of organs located in the right and left side of the abdomen which clear "poisons" from the blood, regulate acid concentration and maintain water balance in the body by excreting urine. The kidneys are part of the urinary tract. The urine then passes through connecting tubes called "ureters" into the bladder. The bladder stores the urine until it is released during urination.

Kidney transplant: Replacement of a diseased, damaged, or missing kidney with a donor kidney. Also called a renal transplant.
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Liver: An organ in the upper abdomen that aids in digestion and removes waste products and worn-out cells from the blood. The liver is the largest solid organ in the body. The liver weighs about three and a half pounds (1.6 kilograms). It measures about 8 inches (20 cm) horizontally (across) and 6.5 inches (17 cm) vertically (down) and is 4.5 inches (12 cm) thick.

Liver disease: Liver disease refers to any disorder of the liver. The liver is a large organ in the upper right abdomen that aids in digestion and removes waste products from the blood.
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Lungs: The lungs are a pair of breathing organs located with the chest which remove carbon dioxide from and bring oxygen to the blood. There is a right and left lung.

Lupus: A chronic inflammatory condition caused by an autoimmune disease. An autoimmune disease occurs when the body's tissues are attacked by its own immune system. Patients with lupus have unusual antibodies in their blood that are targeted against their own body tissues.
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Lymphoma: Tumor of the lymphoid tissue. Diagnosis is by biopsy. Treatment may be chemotherapy, radiation, surgery, or medication, depending on the age of the patient and type of tumor.

Marrow: The bone marrow.

Mouth: 1. The upper opening of the digestive tract, beginning with the lips and containing the teeth, gums, and tongue. Foodstuffs are broken down mechanically in the mouth by chewing and saliva is added as a lubricant. Saliva contains amylase, an enzyme that digests starch. 2. Any opening or aperture in the body. The mouth in both senses of the word is also called the os, the Latin word for an opening, or mouth. The o in os is pronounced as in hope. The genitive form of os is oris from which comes the word oral.

Mucous: Pertaining to mucus, a thick fluid produced by the lining of some tissues of the body.
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Multiple myeloma: A malignancy of plasma cells (a form of lymphocyte) that typically involves multiple sites within the bone morrow and secretes all or part of a monoclonal antibody . Also called plasma cell myeloma.

Myeloma: A tumor of antibody-producing cells, called plasma cells, that are normally found in the bone marrow.

Nausea: Nausea, is the urge to vomit. It can be brought by many causes including, systemic illnesses, such as influenza, medications, pain, and inner ear disease. When nausea and/or vomiting are persistent, or when they are accompanied by other severe symptoms such as abdominal pain, jaundice, fever, or bleeding, a physician should be consulted.

Necrosis: The death of living cells or tissues. Necrosis can be due, for example, to ischemia (lack of blood flow). From the Greek "nekros" (dead body).

Nephritis: Inflammation of the kidney. Nephritis can be acute or chronic.
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Nephrologist: A medical specialist in nephrology (the study of the kidney or "kidney-ology").

Nephropathy: Any kidney disease. For example, there is diabetic nephropathy, gouty nephropathy, HIV-associated nephropathy, ischemic nephropathy, sickle cell nephropathy,and so on. From the Greek "nephros" (kidney) + "pathos" (disease).

Neurological: Having to do with the nerves or the nervous system.

Nose: The external midline projection from the face.
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Nuclear medicine: The branch of medicine concerned with the use of radioisotopes in the diagnosis, management, and treatment of disease. Nuclear medicine uses small amounts of radioactive materials or radiopharmaceuticals, substances that are attracted to specific organs, bones, or tissues. The radiopharmaceuticals used in nuclear medicine emit gamma rays that can be detected externally by special types of cameras: gamma or PET cameras. These cameras work in conjunction with computers used to form images that provide data and information about the area of body being imaged. The amount of radiation from a nuclear medicine procedure is comparable to that received during a diagnostic x-ray.

Operation: Although there are many meanings to the word "operation", in medicine it refers to a surgical procedure.
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Organ: A relatively independent part of the body that carries out one or more special functions. The organs of the human body include the eye, ear, heart, lungs, and liver.

Organ failure: The failure of an essential system in the body. Multiple organ failure is the failure of two or more systems, such as the cardiovascular, and renal systems, and is a common consequence of sepsis (the presence of bacteria in the bloods) and of shock (very low blood pressure).

Osteodystrophy: A bone disorder that adversely affects bone growth. See also renal osteodystrophy.

Osteoporosis: Thinning of the bones with reduction in bone mass due to depletion of calcium and bone protein. Osteoporosis predisposes a person to fractures, which are often slow to heal and heal poorly. It is more common in older adults, particularly post-menopausal women; in patients on steroids; and in those who take steroidal drugs. Unchecked osteoporosis can lead to changes in posture, physical abnormality (particularly the form of hunched back known colloquially as "dowager's hump"), and decreased mobility.
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Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia. Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors.
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Pediatric: Pertaining to children.

Perineum: The area between the anus and the scrotum in the male and between the anus and the vulva (the labial opening to the vagina) in the female. An episiotomy is a surgical procedure to widen the outlet of the birth canal to facilitate delivery of the baby and avoid a jagged rip of the perineum.

Pharmacy: A location where prescription drugs are sold. A pharmacy is, by law, constantly supervised by a licensed pharmacist.

Polycystic kidney disease: One of the genetic disorders characterized by the development of innumerable cysts in the kidneys. These cysts are filled with fluid, and replace much of the mass of the kidneys. This reduces kidney function, leading to kidney failure.
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Pregnant: The state of carrying a developing fetus within the body.
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Progressive: Increasing in scope or severity. Advancing. Going forward. In medicine, a disease that is progressive is going from bad to worse.

Proteins: Large molecules composed of one or more chains of amino acids in a specific order determined by the base sequence of nucleotides in the DNA coding for the protein.
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Prune belly syndrome: Partial or complete absence of the abdominal muscles so that the outlines of the intestines are visible through the thin, lax, protruding abdominal wall. The abdominal wall looks shrunken, shriveled and wrinkled like a prehistoric prune.
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Pulmonary: Having to do with the lungs. (The word comes from the Latin pulmo for lung).

Pulmonary edema: Fluid in the lungs.

Quality of life: An important consideration in medical care, quality of life refers to the patient's ability to enjoy normal life activities. Some medical treatments can seriously impair quality of life without providing appreciable benefit, while others greatly enhance quality of life.

Recipient: In medicine, a recipient is someone who receives something like a blood transfusion or an organ transplant. The recipient is beholden to the donor.

Red blood cells: The blood cells that carry oxygen. Red cells contain hemoglobin and it is the hemoglobin which permits them to transport oxygen (and carbon dioxide). Hemoglobin, aside from being a transport molecule, is a pigment. It gives the cells their red color (and their name).
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Reflux: The term used when liquid backs up into the esophagus from the stomach.

Regimen: With the accent on the first syllable (reg as in Reggie Jackson), a regimen is a plan, a regulated course such as a diet, exercise or treatment, designed to give a good result. A low-salt diet is a regimen.

Rehabilitation: The process of restoration of skills by a person who has had an illness or injury so as to regain maximum self-sufficiency and function in a normal or as near normal manner as possible. For example, rehabilitation after a stroke may help the patient walk again and speak clearly again.
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Rejection: In transplantation biology, the refusal by the body to accept transplanted cells, tissues or organs. For example, a kidney transplanted may be rejected.

Relapse: The return of signs and symptoms of a disease after a patient has enjoyed a remission. For example, after treatment a patient with cancer of the colon went into remission with no sign or symptom of the tumor, remained in remission for 4 years, but then suffered a relapse and had to be treated once again for colon cancer.
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Renal: Having to do with the kidney. From the Latin renes (the kidneys), which gave the French les reins which mean both the kidneys and the lower back.

Renal cell carcinoma: Cancer that develops in the lining of the renal tubules, which filter the blood and produce the urine. Also called renal cell cancer.

Renal osteodystrophy: A combination of bone disorders usually caused by chronic kidney failure (renal disease). Can also occur because of abnormal kidney functioning at birth (congenital). When the kidneys have failed, death is imminent unless dialysis is given. Therefore, patients with osteodystrophy are usually on dialysis therapy. This bone disease, which is also simply called osteodystrophy, is common in patients on chronic hemodialysis.

Resolution: In genetics, resolution refers to the degree of molecular detail on a physical map of DNA, ranging from low to high.

Rheumatoid arthritis: An autoimmune disease which causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Autoimmune diseases occur when the body tissues are mistakenly attacked by its own immune system. The immune system is a complex organization of cells and antibodies designed normally to "seek and destroy" invaders of the body, particularly infections. Patients with these diseases have antibodies in their blood which target their own body tissues, where they can be associated with inflammation. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease. While rheumatoid arthritis is a chronic illness (meaning it can last for years) patients may experience long periods without symptoms.
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Sarcoma: One of a group of tumors usually arising from connective tissue. Most sarcomas are malignant. Many types are named after the type of cell, tissue, or structure involved, as in angiosarcoma, chondrosarcoma, fibrosarcoma, liposarcoma,and osteosarcoma.

Scan: As a noun, the data or image obtained from the examination of organs or regions of the body by gathering information with a sensing device.
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Scleroderma: A disease of connective tissue with the formation of scar tissue (fibrosis) in the skin and sometimes also in other organs of the body.
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Sclerosis: Localized hardening of skin.

Shortness of breath: Difficulty in breathing. Medically referred to as dyspnea. Shortness of breath can be caused by respiratory (breathing passages and lungs) or circulatory (heart and blood vessels) conditions. See also dyspnea.

Sickle cell anemia: A genetic blood disease due to the presence of an abnormal form of hemoglobin, namely hemoglobin S. Hemoglobin is the molecule in red blood cells that transports oxygen from the lungs to the farthest areas of the body.
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Sirolimus: A naturally occurring substance discovered in a soil sample from Easter Island. Sirolimus was initially thought to hold promise as an antifungal antibiotic but this idea was dropped when sirolimus was unexpectedly found to have immunosuppressive activity. The US Food and Drug Administration in 1999 approved the use of sirolimus as an immunosuppressant agent. But earlier in the nineties, evidence had been uncovered that sirolimus was also a potent inhibitor of the growth of smooth muscle cells in blood vessels. The idea was then "hatched" that sirolimus might be used to inhibit the restenosis (reclosure) of coronary arteries. (Today, after a balloon angioplasty has been done to open a clogged coronary artery, a mesh tube called a stent is often inserted to keep the artery open. However, restenosis occurs in up to a third of cases when smooth muscle cells migrate from the vessel wall into the stent. The muscle cells proliferate there and narrow the interior diameter of the stent.) To prevent restenosis, stents coated, or "medicated", with sirolimus came into use. The sirolimus is eluted continuously from the stent and deters or slows restenosis.

Squamous cell carcinoma: Cancer that begins in squamous cells -- thin, flat cells that look under the microscope like fish scales. Squamous cells are found in the tissue that forms the surface of the skin, the lining of hollow organs of the body, and the passages of the respiratory and digestive tracts. Squamous cell carcinomas may arise in any of these tissues.
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Stomach: 1. The sac-shaped digestive organ that is located in the upper abdomen, under the ribs. The upper part of the stomach connects to the esophagus, and the lower part leads into the small intestine.
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Surgeon: A physician who treats disease, injury, or deformity by operative or manual methods. A medical doctor specialized in the removal of organs, masses and tumors and in doing other procedures using a knife (scalpel). The definition of a "surgeon" has begun to blur in recent years as surgeons have begun to minimize the cutting, employ new technologies that are "minimally invasive," use scopes, etc.
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Surgery: The word "surgery" has multiple meanings. It is the branch of medicine concerned with diseases and conditions which require or are amenable to operative procedures. Surgery is the work done by a surgeon. By analogy, the work of an editor wielding his pen as a scalpel is s form of surgery. A surgery in England (and some other countries) is a physician's or dentist's office.
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Syndrome: A set of signs and symptoms that tend to occur together and which reflect the presence of a particular disease or an increased chance of developing a particular disease.
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Systemic: Affecting the entire body. A systemic disease such as diabetes can affect the whole body. Systemic chemotherapy employs drugs that travel through the bloodstream and reach and affect cells all over the body.

Systemic lupus erythematosus: A chronic inflammatory condition caused by an autoimmune disease. An autoimmune disease occurs when the body's tissues are attacked by its own immune system. Patients with lupus have unusual antibodies in their blood that are targeted against their own body tissues.
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Tachycardia: A rapid heart rate, usually defined as greater than 100 beats per minute. The tachycardias include sinus tachycardia, paroxysmal atrial tachycardia (PAT), and ventricular tachycardia.
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Tacrolimus: A drug that suppresses the immune system and prevents transplant rejection. The drug acts by inhibiting the activation of T cells.
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Thrombosis: The formation or presence of a blood clot in a blood vessel. The vessel may be any vein or artery as, for example, in a deep vein thrombosis or a coronary (artery) thrombosis. The clot itself is termed a thrombus. If the clot breaks loose and travels through the bloodstream, it is a thromboembolism. Thrombosis, thrombus, and the prefix thrombo- all come from the Greek thrombos meaning a lump or clump, or a curd or clot of milk. See entries also to: Cavernous sinus thrombosis; Renal vein thrombosis. And see: Deep Vein Thrombosis and Pulmonary Embolism.

Transplant: The grafting of a tissue from one place to another, just as in botany a bud from one plant might be grafted onto the stem of another. The transplanting of tissue can be from one part of the patient to another (autologous transplantation), as in the case of a skin graft using the patient's own skin; or from one patient to another (allogenic transplantation), as in the case of transplanting a donor kidney into a recipient.

Tremor: Any abnormal repetitive shaking movement of the body. Tremors have many causes and can be inherited, be related to illnesses such as thyroid disease, or caused by fever, hypothermia, drugs or fear.

Tumor: An abnormal mass of tissue. Tumors are a classic sign of inflammation, and can be benign or malignant (cancerous). There are dozens of different types of tumors. Their names usually reflect the kind of tissue they arise in, and may also tell you something about their shape or how they grow. For example, a medulloblastoma is a tumor that arises from embryonic cells (a blastoma) in the inner part of the brain (the medulla). Diagnosis depends on the type and location of the tumor. Tumor marker tests and imaging may be used; some tumors can be seen (for example, tumors on the exterior of the skin) or felt (palpated with the hands).
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Ureter: A tube that carries urine down from the kidney to the bladder.
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Urinary: Having to do with the kidneys, ureters, and bladder. The urinary system represents the functional and anatomic aspects of the kidneys, ureters, and bladder.

Urinary tract: The organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra.

Urine: Liquid waste. The urine is a clear, transparent fluid. It normally has an amber color. The average amount of urine excreted in 24 hours is from 40 to 60 ounces (about 1,200 cubic centimeters). Chemically, the urine is mainly an aqueous (watery) solution of salt (sodium chloride) and substances called urea and uric acid. Normally, it contains about 960 parts of water to 40 parts of solid matter. Abnormally, it may contain sugar (in diabetes), albumen (a protein) (as in some forms of kidney disease), bile pigments (as in jaundice), or abnormal quantities of one or another of its normal components.

Vascular: Relating to the blood vessels of the body. The blood vessels of the body, as a group, are referred to as the vascular system.
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Vein: A blood vessel that carries blood low in oxygen content from the body back to the heart. The deoxygenated form of hemoglobin (deoxyhemoglobin) in venous blood makes it appear dark. Veins are part of the afferent wing of the circulatory system which returns blood to the heart.
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Vulva: The female external genital organs including the labia majora, labia minora, clitoris, tiny glands called Bartolin's glands, and the entrance to the vagina (the vestibule of the vagina).

Wilms tumor: A cancer of the kidney and one of the most important malignancies in childhood, due to loss or inactivation of a tumor suppressor gene called WT1 on chromosome 11. Tumor suppressor genes usually suppress the growth of tumors and control cell growth.
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