Lorenzo's Oil

How does Lorenzo's Oil work?

Adrenoleukodystrophy and adrenomyeloneuropathy are two rare genetic disorders that cause a large buildup of certain chemicals called very-long chain fatty acids. Lorenzo's oil might help prevent some of this buildup. The buildup of these acids is thought to cause many serious problems throughout the brain and body.

Are there safety concerns?

Lorenzo's oil seems to be safe when used under the care of health professionals. There is concern that Lorenzo's oil might cause two blood disorders known as thrombocytopenia (decrease in blood platelets needed for clotting blood) and neutropenia (decrease in white blood cells needed to fight infections). Side effects of Lorenzo's oil can include bruising and bleeding.

Do not take Lorenzo's oil if:

• You are pregnant or breast-feeding.
• You have a blood disorder called thrombocytopenia or neutropenia.

Dosing considerations for Lorenzo's Oil.

The following doses have been studied in scientific research:

BY MOUTH:

• For adrenoleukodystrophy (ALD): a dose of Lorenzo's oil that provides about 20% of daily calories has been used. In another study, 300 mg/kg/day of erucic acid and 1.7 grams/kg/day of oleic acid (both contained in Lorenzo's oil) were used.