Lupus (Systemic Lupus Erythematosus) Glossary of Terms

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Abdomen: The belly, that part of the body that contains all of the structures between the chest and the pelvis. The abdomen is separated anatomically from the chest by the diaphragm, the powerful muscle spanning the body cavity below the lungs.
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Abdominal: Relating to the abdomen, the belly, that part of the body that contains all of the structures between the chest and the pelvis. The abdomen is separated anatomically from the chest by the diaphragm, the powerful muscle spanning the body cavity below the lungs.
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Abdominal pain: Pain in the belly (the abdomen). Abdominal pain can come from conditions affecting a variety of organs. The abdomen is an anatomical area that is bounded by the lower margin of the ribs above, the pelvic bone (pubic ramus) below, and the flanks on each side. Although abdominal pain can arise from the tissues of the abdominal wall that surround the abdominal cavity (the skin and abdominal wall muscles), the term abdominal pain generally is used to describe pain originating from organs within the abdominal cavity (from beneath the skin and muscles). These organs include the stomach, small intestine, colon, liver, gallbladder, and pancreas.
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Acute: Of abrupt onset, in reference to a disease. Acute often also connotes an illness that is of short duration, rapidly progressive, and in need of urgent care.
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Acute kidney failure: See: Acute renal failure.

Alopecia: Baldness. There are many types of alopecia, each with a different cause. Alopecia may be localized to the front and top of the head as in common male pattern baldness. It may be patchy as in a condition called alopecia areata. Or it can involve the entire head as in alopecia capitis totalis. The word "alopecia" comes from the Greek "alopex" for "fox." Foxes are less furry when afflicted with a skin disease (the "mange") which causes them to lose their hair. When a fancier word for "baldness" was sought, the mangy fox supplied it -- "alopecia" or, if you wish, "fox-mange" -- not a very positive image to associate with baldness!

Analysis: A psychology term for processes used to gain understanding of complex emotional or behavioral issues.

Anemia: The condition of having less than the normal number of red blood cells or less than the normal quantity of hemoglobin in the blood. The oxygen-carrying capacity of the blood is, therefore, decreased.
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Angina: Chest pain due to an inadequate supply of oxygen to the heart muscle. The chest pain of angina is typically severe and crushing. There is a feeling just behind the breastbone (the sternum) of pressure and suffocation.
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Antibody: An immunoglobulin, a specialized immune protein, produced because of the introduction of an antigen into the body, and which possesses the remarkable ability to combine with the very antigen that triggered its production.
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Anticoagulant: Any agent used to prevent the formation of blood clots.
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Antidepressants: Anything, and especially a drug, used to prevent or treat depression.
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Antimalarial: A drug directed against malaria. The original antimalarial agent was quinine which took its name from the Peruvian Indian word "kina" meaning "bark of the tree." A large and complex molecule, quinine is the most important alkaloid found in cinchona bark. Until World War I, it was the only effective treatment for malaria. In fact, quinine was the first chemical compound to be successfully used to treat an infectious disease.
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Antinuclear antibody: An unusual antibody that is directed against structures within the nucleus of the cell. Antinuclear antibodies (ANAs) are found in patients whose immune system is predisposed to cause inflammation against their own body tissues. Antibodies that are directed against one's own tissues are referred to as autoantibodies. The propensity for the immune system to work against its own body is referred to as autoimmunity. ANAs indicate the possible presence of autoimmunity.
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Arms: An appendage in anatomy and in clinical trials. See: Arm.

Artery: A vessel that carries blood high in oxygen content away from the heart to the farthest reaches of the body. Since blood in arteries is usually full of oxygen, the hemoglobin in the red blood cells is oxygenated. The resultant form of hemoglobin (oxyhemoglobin) is what makes arterial blood look bright red.
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Arthralgia: Pain in the joints. There are many possible causes of pain in a joint. The Greek "algos" means "pain."

Arthritis: Inflammation of a joint. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis. (see osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout, pseudogout).

Ascites: Abnormal buildup of fluid in the abdomen. Ascites can occur as a result of a number of conditions, including severe liver disease and the presence of malignant cells within the abdomen.

Aspirin: A good example of a tradename that entered into the language, Aspirin was once the Bayer trademark for acetylsalicylic acid.
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Atherosclerosis: A process of progressive thickening and hardening of the walls of medium-sized and large arteries as a result of fat deposits on their inner lining.
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Autoimmune: Pertaining to autoimmunity, a misdirected immune response that occurs when the immune system goes awry and attacks the body itself.
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Autoimmune disease: An illness that occurs when the body tissues are attacked by its own immune system. The immune system is a complex organization within the body that is designed normally to "seek and destroy" invaders of the body, including infectious agents. Patients with autoimmune diseases frequently have unusual antibodies circulating in their blood that target their own body tissues.
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Avascular necrosis: (AVN) A condition in which the poor blood supply to an area of bone leads to bone death. The head of the femur is often the site of AVN. Also called avascular necrosis and osteonecrosis.

Blood clot: Blood that has been converted from a liquid to a solid state. Also called a thrombus.
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Blood clots: Blood that has been converted from a liquid to a solid state. Also called a thrombus.
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Blood in the urine: Blood in the urine is termed hematuria.
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Blood pressure: The blood pressure is the pressure of the blood within the arteries. It is produced primarily by the contraction of the heart muscle. It's measurement is recorded by two numbers. The first (systolic pressure) is measured after the heart contracts and is highest. The second (diastolic pressure) is measured before the heart contracts and lowest. A blood pressure cuff is used to measure the pressure. Elevation of blood pressure is called "hypertension".

Blush: A redness of the skin, typically over the cheeks or neck. A blush is usually temporary and brought on by excitement, exercise, fever, or embarrassment. Blushing is an involuntary (uncontrollable) response of the nervous system leading to widening of the capillaries of the involved skin. Also referred to as a flush.

Brain: That part of the central nervous system that is located within the cranium (skull). The brain functions as the primary receiver, organizer and distributor of information for the body. It has two (right and left) halves called "hemispheres."

Cataract: A clouding or loss of transparency of the lens in the eye as a result of tissue breakdown and protein clumping. There are many causes of cataracts, including aging, cortisone medication, trauma, diabetes, and other diseases. Cataracts affect most people who live into an old age. Symptoms include double or blurred vision and sensitivity to light and glare. A physician can diagnose cataracts by examining the eyes with a viewing instrument. Sunglasses can help to prevent cataracts.
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Cell: The basic structural and functional unit in people and all living things. Each cell is a small container of chemicals and water wrapped in a membrane.
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Cerebral: Pertaining to the brain, the cerebrum or the intellect.
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Cerebritis: Inflammation of the brain.

Chest: The area of the body located between the neck and the abdomen. The chest contains the lungs, the heart and part of the aorta. The walls of the chest are supported by the dorsal vertebrae, the ribs, and the sternum.
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Chest pain: There are many causes of chest pain. One is angina which results from inadequate oxygen supply to the heart muscle. Angina can be caused by coronary artery disease or spasm of the coronary arteries. Chest pain can also be due to a heart attack (coronary occlusion) and other important diseases such as, for example, dissection of the aorta and a pulmonary embolism. Do not try to ignore chest pain and "work (or play) though it." Chest pain is a warning to seek medical attention.

Chronic: This important term in medicine comes from the Greek chronos, time and means lasting a long time.
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Chronic disease: A disease that persists for a long time. A chronic disease is one lasting 3 months or more, by the definition of the U.S. National Center for Health Statistics. Chronic diseases generally cannot be prevented by vaccines or cured by medication, nor do they just disappear. Eighty-eight percent of Americans over 65 years of age have at least one chronic health condition (as of 1998). Health damaging behaviors - particularly tobacco use, lack of physical activity, and poor eating habits - are major contributors to the leading chronic diseases.
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Chronic illness: An illness that persists for a long period of time. The term "chronic" comes from the Greek chronos, time and means lasting a long time.
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Contrast: Short for "contrast media." Contrast media are X-ray dyes used to provide contrast, for example, between blood vessels and other tissue.

Cutaneous: Relating to the skin. As, for example, in cutaneous allodynia, a cutaneous papilloma, and cutaneous syndactyly. From the Latin cutis meaning skin.

Dehydroepiandrosterone: DHEA. A steroid hormone made by the adrenal glands that acts on the body much like testosterone and is converted into testosterone and estrogen. DHEA and its sulfate (DHEAS) are abundant in the body, but their normal roles are not fully understood. The blood levels of DHEA and DHEAS decline with age.
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Depression: An illness that involves the body, mood, and thoughts, that affects the way a person eats and sleeps, the way one feels about oneself, and the way one thinks about things. A depressive disorder is not the same as a passing blue mood. It is not a sign of personal weakness or a condition that can be wished away. People with a depressive disease cannot merely "pull themselves together" and get better. Without treatment, symptoms can last for weeks, months, or years. Appropriate treatment, however, can help most people with depression.
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DHEA: Dehydroepiandrosterone.

Diabetes: Refers to diabetes mellitus or, less often, to diabetes insipidus. Diabetes mellitus and diabetes insipidus share the name "diabetes" because they are both conditions characterized by excessive urination (polyuria).
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Diagnosis: 1 The nature of a disease; the identification of an illness. 2 A conclusion or decision reached by diagnosis. The diagnosis is rabies. 3 The identification of any problem. The diagnosis was a plugged IV.
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Discoid lupus: A chronic inflammatory condition limited to the skin, caused by an autoimmune disease. An autoimmune disease occurs when the body's tissues are attacked by its own immune system. Patients with lupus have unusual antibodies in their blood that are targeted against their own body tissues.
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DNA: Deoxyribonucleic acid. One of two types of molecules that encode genetic information. (The other is RNA. In humans DNA is the genetic material; RNA is transcribed from it. In some other organisms, RNA is the genetic material and, in reverse fashion, the DNA is transcribed from it.)
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Dysfunction: Difficult function or abnormal function.
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Echinacea: An herb that has been claimed to boost the body's immune system and help fight off infections. Echinacea has been widely used to treat the symptoms of upper respiratory tract infections (URIs), including colds and the flu. The herb is derived from the purple coneflower, Echinacea purpurea, a drought-tolerant perennial plant native to North America with large purple flowers surrounding a large cone.
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Emergency department: The department of a hospital responsible for the provision of medical and surgical care to patients arriving at the hospital in need of immediate care. Emergency department personnel may also respond to certain situations within the hospital such cardiac arrests.
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Emergency physician: A physician focused on the immediate decision making and action necessary to prevent death or any further disability both in the prehospital setting by directing emergency medical technicians and in the emergency department. The emergency physician provides immediate recognition, evaluation, care, stabilization, and disposition of a generally diversified population of adult and pediatric patients in response to acute illness and injury.

Estrogen: Estrogen is a female hormone produced by the ovaries. Estrogen deficiency can lead to osteoporosis.
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Estrogens: Female hormones produced by the ovaries. Estrogen deficiency can lead to osteoporosis.
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Father: (1) The male parent. (2) One who originates. For example, "Wilhelm Roentgen is considered the father of radiology." (3) To produce offspring as a male. (4) To provide paternal protection and guidance to children.

Fatigue: A condition characterized by a lessened capacity for work and reduced efficiency of accomplishment, usually accompanied by a feeling of weariness and tiredness. Fatigue can be acute and come on suddenly or chronic and persist.
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Fertility: The ability to conceive and have children, the ability to become pregnant through normal sexual activity. Infertility is defined as the failure to conceive after a year of regular intercourse without contraception.
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Fetus: The unborn offspring from the end of the 8^th week after conception (when the major structures have formed) until birth. Up until the eighth week, the developing offspring is called an embryo.

Fever: Although a fever technically is any body temperature above the normal of 98.6 degrees F. (37 degrees C.), in practice a person is usually not considered to have a significant fever until the temperature is above 100.4 degrees F (38 degrees C.).
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Genetic: Having to do with genes and genetic information.

Hair loss: Hair loss is the thinning of hair on the scalp. The medical term for hair loss is alopecia. Alopecia can be temporary or permanent. The most common form of hair loss occurs gradually and is referred to as "androgenetic alopecia," meaning that a combination of hormones (androgens are male hormones) and heredity (genetics) is needed to develop the condition. Other types of hair loss include alopecia areata (patches of baldness that usually grow back), telogen effluvium (rapid shedding after childbirth, fever, or sudden weight loss); and traction alopecia (thinning from tight braids or ponytails).
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Headache: A pain in the head with the pain being above the eyes or the ears, behind the head (occipital), or in the back of the upper neck. Headache, like chest pain or back ache, has many causes.
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Heart: The muscle that pumps blood received from veins into arteries throughout the body. It is positioned in the chest behind the sternum (breastbone; in front of the trachea, esophagus, and aorta; and above the diaphragm muscle that separates the chest and abdominal cavities. The normal heart is about the size of a closed fist, and weighs about 10.5 ounces. It is cone-shaped, with the point of the cone pointing down to the left. Two-thirds of the heart lies in the left side of the chest with the balance in the right chest.
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Heart attack: The death of heart muscle due to the loss of blood supply. The loss of blood supply is usually caused by a complete blockage of a coronary artery, one of the arteries that supplies blood to the heart muscle. Death of the heart muscle, in turn, causes chest pain and electrical instability of the heart muscle tissue.
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Heart block: A block in the conduction of the normal electrical impulses in the heart.

Heart rate: The number of heart beats per unit time, usually per minute. The heart rate is based on the number of contractions of the ventricles (the lower chambers of the heart). The heart rate may be too fast (tachycardia) or too slow (bradycardia). The pulse is bulge of an artery from the wave of blood coursing through the blood vessel as a result of the heart beat. The pulse is often taken at the wrist to estimate the heart rate.

Heart valves: There are four heart valves. All are one-way valves. Blood entering the heart first passes through the tricuspid valve and then the pulmonary valve. After returning from the lungs, the blood passes through the mitral (bicuspid) valve and exits via the aortic valve.

Heparin: An anticoagulant (anti-clotting) medication. Heparin is useful in preventing thromboembolic complications (clots that travel from their site of origin through the blood stream to clog up another vessel). Heparin is also used in the early treatment of blood clots in the lungs (pulmonary embolisms).

High blood pressure: Also known as hypertension, high blood pressure is, by definition, a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140 with a diastolic pressure above 90.
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Ibuprofen: A non-steroidal anti-inflammatory drug (NSAID) commonly used to treat pain, swelling, and fever. Common brand names for Ibuprofen include Advil, Motrin, and Nuprin.

Immune: Protected against infection. The Latin immunis means free, exempt.

Immune system: A complex system that is responsible for distinguishing us from everything foreign to us, and for protecting us against infections and foreign substances. The immune system works to seek and kill invaders.
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Immunosuppressive: 1. Pertaining to immunosuppression, the suppression of the immune system.
2. An agent capable of suppressing the immune response.

Incidence: The frequency with which something, such as a disease, appears in a particular population or area. In disease epidemiology, the incidence is the number of newly diagnosed cases during a specific time period. The incidence is distinct from the prevalence which refers to the number of cases alive on a certain date.

Infant: A child up to 2 years (24 months) of age.
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Infection: The growth of a parasitic organism within the body. (A parasitic organism is one that lives on or in another organism and draws its nourishment therefrom.) A person with an infection has another organism (a "germ") growing within him, drawing its nourishment from the person.
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Inflammation: A basic way in which the body reacts to infection, irritation or other injury, the key feature being redness, warmth, swelling and pain. Inflammation is now recognized as a type of nonspecific immune response.
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Injury: Harm or hurt. The term "injury" may be applied in medicine to damage inflicted upon oneself as in a hamstring injury or by an external agent on as in a cold injury. The injury may be accidental or deliberate, as with a needlestick injury. The term "injury" may be synonymous (depending on the context) with a wound or with trauma.

Internal bleeding: Bleeding inside the body that is not seen from the outside. Internal bleeding occurs when damage to an artery or vein allows blood to escape the circulatory system and collect inside the body. The internal bleeding may occur within tissues, organs, or in cavities of the body including the head, chest, and abdomen. Examples of other potential sites of bleeding include the eye, lining tissues of the heart, muscles, and joints. Internal bleeding may not be evident for many hours after it begins, and symptoms occur when there is significant blood loss or if a blood clot is large enough to compress an organ and prevent it from functioning properly.

Internal medicine: A medical specialty dedicated to the diagnosis and medical treatment of adults. A physician who specializes in internal medicine is referred to as an internist. A minimum of seven years of medical school and postgraduate training are focused on learning the prevention, diagnosis, and treatment of diseases of adults. Subspecialties of internal medicine include allergy and immunology, cardiology (heart), endocrinology (hormone disorders), hematology (blood disorders), infectious diseases, gastroenterology (diseases of the gut), nephrology (kidney diseases), oncology (cancer), pulmonology (lung disorders), and rheumatology (arthritis and musculoskeletal disorders).

Joint: A joint is the area where two bones are attached for the purpose of motion of body parts. A joint is usually formed of fibrous connective tissue and cartilage. An articulation or an arthrosis is the same as a joint.
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Kidney: One of a pair of organs located in the right and left side of the abdomen which clear "poisons" from the blood, regulate acid concentration and maintain water balance in the body by excreting urine. The kidneys are part of the urinary tract. The urine then passes through connecting tubes called "ureters" into the bladder. The bladder stores the urine until it is released during urination.

Laboratory: A place for doing tests and research procedures and preparing chemicals, etc. Although "laboratory" looks very like the Latin "laboratorium" (a place to labor, a work place), the word "laboratory" came from the Latin "elaborare" (to work out, as a problem, and with great pains), as evidenced by the Old English spelling "elaboratory" designating "a place where learned effort was applied to the solution of scientific problems."

Leg: In popular usage, the leg extends from the top of the thigh down to the foot. However, in medical terminology, the leg refers to the portion of the lower extremity from the knee to the ankle.
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Leukopenia: Lower than the normal amount of white blood cells.

Liver: An organ in the upper abdomen that aids in digestion and removes waste products and worn-out cells from the blood. The liver is the largest solid organ in the body. The liver weighs about three and a half pounds (1.6 kilograms). It measures about 8 inches (20 cm) horizontally (across) and 6.5 inches (17 cm) vertically (down) and is 4.5 inches (12 cm) thick.

Lungs: The lungs are a pair of breathing organs located with the chest which remove carbon dioxide from and bring oxygen to the blood. There is a right and left lung.

Lupus: A chronic inflammatory condition caused by an autoimmune disease. An autoimmune disease occurs when the body's tissues are attacked by its own immune system. Patients with lupus have unusual antibodies in their blood that are targeted against their own body tissues.
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Lymph: An almost colorless fluid that travels through vessels called lymphatics in the lymphatic system and carries cells that help fight infection and disease.

Malar: Referring to the cheek.

Marker: A piece of DNA that lies on a chromosome so close to a gene that the marker and the gene are inherited together. A marker is thus an identifiable heritable spot on a chromosome. A marker can be an expressed region of DNA (a gene) or a segment of DNA with no known coding function. All that matters is that the marker can be detected and trailed.
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Menstrual: Pertaining to menstruation (the menses), as in last menstrual period, menstrual cramps, menstrual cycle, and premenstrual syndrome. From the Latin menstrualis, from mensis meaning month.

Menstruation: The periodic blood that flows as a discharge from the uterus. Also called menorrhea, the time during which menstruation occurs is referred to as menses. The menses occurs at approximately 4 week intervals to compose the menstrual cycle.

Microscopic: So small it cannot be seen without the aid of microscope. As opposed to macroscopic (large enough to be seen with naked eye). A tiny tumor is microscopic while a big tumor is macroscopic.

Minocin: Brand name for minocycline.

Minocycline: A tetracycline antibiotic used to treat many different bacteria in urinary tract infections, acne, gonorrhea, and chlamydia, and other injections. The brand names for minocycline include Dynacin, Minocin, and Vectrin.
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Miscarriage: Inadvertent loss of a pregnancy before the fetus is viable. A considerable proportion of pregnancies end in a miscarriage. Also called a spontaneous abortion.

Mouth: 1. The upper opening of the digestive tract, beginning with the lips and containing the teeth, gums, and tongue. Foodstuffs are broken down mechanically in the mouth by chewing and saliva is added as a lubricant. Saliva contains amylase, an enzyme that digests starch. 2. Any opening or aperture in the body. The mouth in both senses of the word is also called the os, the Latin word for an opening, or mouth. The o in os is pronounced as in hope. The genitive form of os is oris from which comes the word oral.

Muscle: Muscle is the tissue of the body which primarily functions as a source of power. There are three types of muscle in the body. Muscle which is responsible for moving extremities and external areas of the body is called "skeletal muscle." Heart muscle is called "cardiac muscle." Muscle that is in the walls of arteries and bowel is called "smooth muscle."

Myalgia: Pain in a muscle; or pain in multiple muscles. Myalgia means muscle pain. There are many specific causes of various types of myalgia. Myalgia can be temporary or chronic. Myalgia can be a result of a mild conditions, such as a virus infection, or from a more serious illness. Examples include epidemic myalgia and polymyalgia rheumatica.
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Necrosis: The death of living cells or tissues. Necrosis can be due, for example, to ischemia (lack of blood flow). From the Greek "nekros" (dead body).

Neonatal: Pertaining to the newborn period which, by convention, is the first four weeks after birth.

Neonatal lupus: A lupus-like disease in a baby due to the transfer through the placenta of lupus antibodies from the mother who has lupus to the fetus. (By lupus here is meant SLE -- systemic lupus erythematosus.)
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Nephritis: Inflammation of the kidney. Nephritis can be acute or chronic.
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Nerve: A bundle of fibers that uses chemical and electrical signals to transmit sensory and motor information from one body part to another. See: Nervous system.

Neurological: Having to do with the nerves or the nervous system.

Nose: The external midline projection from the face.
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Onset: In medicine, the first appearance of the signs or symptoms of an illness as, for example, the onset of rheumatoid arthritis. There is always an onset to a disease but never to the return to good health. The default setting is good health.
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Ophthalmologist: An eye doctor. A physician practicing ophthalmology. An ophthalmologist is an M.D.

Organ: A relatively independent part of the body that carries out one or more special functions. The organs of the human body include the eye, ear, heart, lungs, and liver.

Ovulation: The release of the ripe egg from the ovary. The egg is released when the cavity surrounding it (the follicle) breaks open in response to a hormonal signal. Ovulation occurs around fourteen or fifteen days from the first day of the woman's last menstrual cycle. When ovulation occurs, the ovum moves into the fallopian tube and becomes available for fertilization.

Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia. Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors.
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Paralysis: Loss of voluntary movement (motor function). Paralysis that affects only one muscle or limb is partial paralysis, also known as palsy; paralysis of all muscles is total paralysis, as may occur in cases of botulism.

Pericarditis: Inflammation of the lining around the heart (the pericardium) causing chest pain and accumulation of fluid around the heart (pericardial effusion).

Pharmacy: A location where prescription drugs are sold. A pharmacy is, by law, constantly supervised by a licensed pharmacist.

Phlebitis: Inflammation of a vein. With phlebitis there is infiltration of the walls of the vein and, usually, the formation of a clot (thrombus) in the vein (thrombophlebitis). Phlebitis in a leg, for example, will cause the leg to swell with edema fluid and feel stiff and painful.

Phosphate: A form of phosphoric acid. Calcium phosphate makes bones and teeth hard.

Photosensitivity: In medicine, increased sensitivity of the skin to light and other sources of UV. Photosensitivity commonly causes reddening and blistering of the skin with exposure to sunlight and, in time, it heightens the risk of skin cancer. A number of diseases make for photosensitivity, as do scores of prescription and non-prescription drugs. (For details, see Sunburn and Sun-Sensitizing Drugs).
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Platelet: An irregular, disc-shaped element in the blood that assists in blood clotting. During normal blood clotting, the platelets clump together (aggregate). Although platelets are often classed as blood cells, they are actually fragments of large bone marrow cells called megakaryocytes.

Pleural: Pertaining to the pleura, the thin covering that protects the lungs. The term "pleural" is pronounced like "plural" (but does not have plural meanings).

Pleurisy: Inflammation of the pleura, the linings surrounding the lungs. There are two layers of pleura; one covering the lung and the other covering the inner wall of the chest. These two layers are lubricated by pleural fluid. Pleurisy is frequently associated with a pleural effusion (the accumulation of extra fluid in the space between the two layers of pleura). Pleurisy causes a stabbing pain in the chest aggravated by breathing, chest tenderness, cough, and shortness of breath. Pleurisy can be caused by many conditions including infections, collagen vascular diseases (such as lupus and rheumatoid arthritis), cancers (such as metastatic lung cancer or breast cancer), tumors of the pleura, heart failure, lung embolism (blood clot in a vessel to the lungs), obstruction of lymph channels, trauma (rib fractures or injury from instruments in the chest from an operation or car accident), certain drugs (such as Hydralazine, Procan, and Dilantin), abdominal processes (such as pancreatitis, cirrhosis of the liver) and lung infarction (lung tissue death due to lack of oxygen from poor blood supply).
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Pneumonia: Inflammation of one or both lungs with consolidation. Pneumonia is frequently but not always due to infection. The infection may be bacterial, viral, fungal or parasitic. Symptoms may include fever, chills, cough with sputum production, chest pain, and shortness of breath.

Pregnancy: The state of carrying a developing embryo or fetus within the female body. This condition can be indicated by positive results on an over-the-counter urine test, and confirmed through a blood test, ultrasound, detection of fetal heartbeat, or an X-ray. Pregnancy lasts for about nine months, measured from the date of the woman's last menstrual period (LMP). It is conventionally divided into three trimesters, each roughly three months long.
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Pregnant: The state of carrying a developing fetus within the body.
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Premature birth: A birth that takes place before 37 weeks of gestation have passed. Historically, the definition of prematurity was 2500 grams (about 5 1/2 pounds) or less at birth. The current World Health Organization definition of prematurity is a baby born before 37 weeks of gestation, counting from the first day of the Last Menstrual Period (the LMP).
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Probability: The likelihood that something will happen. For example, a probability of less than .05 indicates that the probability of something occurring by chance alone is less than 5 in 100, or 5 percent. This level of probability is usually taken as the level of biologic significance, so a higher incidence may be considered meaningful. The abbreviation for probability is P.

Prognosis: 1. The expected course of a disease.
2. The patient's chance of recovery.
The prognosis predicts the outcome of a disease and therefore the future for the patient. His prognosis is grim, for example, while hers is good.
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Protein: A large molecule composed of one or more chains of amino acids in a specific order determined by the base sequence of nucleotides in the DNA coding for the protein.
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Psychiatric: Pertaining to or within the purview of psychiatry, the medical specialty concerned with the prevention, diagnosis, and treatment of mental illness.
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Psychosis: In the general sense, a mental illness that markedly interferes with a person's capacity to meet life's everyday demands. In a specific sense, it refers to a thought disorder in which reality testing is grossly impaired.
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Puberty: A complex biologic and psychologic process involving sexual development, accelerated growth, and adrenal maturation heralded by the secretion of gonadotropin releasing hormone (GnRH) from a part of the brain called the hypothalamus. This event is the first known step in the reproductive cascade. It initiates the pulsatile release of gonadotropins, gonadal secretion of sex steroids, pubertal development, and gametogenesis (the production of sperm and ova).
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Random: The process by which an outcome is determined solely by chance, for example, by a coin flip.
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Rash: Breaking out (eruption) of the skin. Medically, a rash is referred to as an exanthem.

Recurrent: Back again. A recurrent fever is a fever that has returned after an intermission: a recrudescent fever.

Red blood cell: The blood cell that carries oxygen. Red cells contain hemoglobin and it is the hemoglobin which permits them to transport oxygen (and carbon dioxide). Hemoglobin, aside from being a transport molecule, is a pigment. It gives the cell its red color (and name).
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Relapse: The return of signs and symptoms of a disease after a patient has enjoyed a remission. For example, after treatment a patient with cancer of the colon went into remission with no sign or symptom of the tumor, remained in remission for 4 years, but then suffered a relapse and had to be treated once again for colon cancer.
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Remission: Disappearance of the signs and symptoms of cancer or other disease. When this happens, the disease is said to be "in remission." A remission can be temporary or permanent.

Retina: The retina is the nerve layer that lines the back of the eye, senses light, and creates impulses that travel through the optic nerve to the brain. There is a small area, called the macula, in the retina that contains special light-sensitive cells. The macula allows us to see fine details clearly.
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Rheumatoid arthritis: An autoimmune disease which causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Autoimmune diseases occur when the body tissues are mistakenly attacked by its own immune system. The immune system is a complex organization of cells and antibodies designed normally to "seek and destroy" invaders of the body, particularly infections. Patients with these diseases have antibodies in their blood which target their own body tissues, where they can be associated with inflammation. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease. While rheumatoid arthritis is a chronic illness (meaning it can last for years) patients may experience long periods without symptoms.
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Rheumatologist: A specialist in the non-surgical treatment of rheumatic illnesses, especially arthritis.
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Rheumatology: A subspecialty of internal medicine that involves the non-surgical evaluation and treatment of the rheumatic diseases and conditions. Rheumatic diseases and conditions are characterized by symptoms involving the musculoskeletal system. Many of the rheumatic diseases and conditions feature immune system abnormalities. Therefore, rheumatology also involves the study of the immune system. Classical rheumatology training includes 4 years of medical school, 1 year of internship in internal medicine, 2 years of internal medicine residency, and 2 years of rheumatology fellowship. There is a subspecialty board for rheumatology certification. The American College of Rheumatology is the official organization acting on behalf of the field of rheumatology in the United States.

Scaling: Abnormal shedding or accumulation of an upper layer of skin (the stratum corneum).

Sensitivity: 1. In psychology, the quality of being sensitive. As, for example, sensitivity training, training in small groups to develop a sensitive awareness and understanding of oneself and of ones relationships with others. 2. In disease epidemiology, the ability of a system to detect epidemics and other changes in disease occurrence. 3. In screening for a disease, the proportion of persons with the disease who are correctly identified by a screening test. 4. In the definition of a disease, the proportion of persons with the disease who are correctly identified by defined criteria.

Serositis: Inflammation of the serous tissues of the body. The serous tissues line the lungs (pleura), heart (pericardium), and the inner lining of the abdomen (peritoneum) and organs within.

Shortness of breath: Difficulty in breathing. Medically referred to as dyspnea. Shortness of breath can be caused by respiratory (breathing passages and lungs) or circulatory (heart and blood vessels) conditions. See also dyspnea.

Sibling: A brother or sister.

Spasm: A brief, automatic jerking movement. A muscle spasm can be quite painful, with the muscle clenching tightly. A spasm of the coronary artery can cause angina. Spasms in various types of tissue may be caused by stress, medication, over-exercise, or other factors.

SPF (sun protection factor): A number on a scale for rating the degree of protection provided by sunscreens. SPF stands for Sun Protection Factor.
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Spinal cord: The major column of nerve tissue that is connected to the brain and lies within the vertebral canal and from which the spinal nerves emerge. Thirty-one pairs of spinal nerves originate in the spinal cord: 8 cervical, 12 thoracic, 5 lumbar, 5 sacral, and 1 coccygeal. The spinal cord and the brain constitute the central nervous system (CNS). The spinal cord consists of nerve fibers that transmit impulses to and from the brain. Like the brain, the spinal cord is covered by three connective-tissue envelopes called the meninges. The space between the outer and middle envelopes is filled with cerebrospinal fluid (CSF), a clear colorless fluid that cushions the spinal cord against jarring shock. Also known simply as the cord.
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Steroid: A general class of chemical substances that are structurally related to one another and share the same chemical skeleton (a tetracyclic cyclopenta[a]phenanthrene skeleton).
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Stomach: 1. The sac-shaped digestive organ that is located in the upper abdomen, under the ribs. The upper part of the stomach connects to the esophagus, and the lower part leads into the small intestine.
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Sunscreen: A substance that blocks the effect of the sun's harmful rays. Using lotions that contain sunscreens can reduce the risk of skin cancer, including melanoma.

Symptom: Any subjective evidence of disease. Anxiety, lower back pain, and fatigue are all symptoms. They are sensations only the patient can perceive. In contrast, a sign is objective evidence of disease. A bloody nose is a sign. It is evident to the patient, doctor, nurse and other observers.

Syndrome: A set of signs and symptoms that tend to occur together and which reflect the presence of a particular disease or an increased chance of developing a particular disease.
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Systemic: Affecting the entire body. A systemic disease such as diabetes can affect the whole body. Systemic chemotherapy employs drugs that travel through the bloodstream and reach and affect cells all over the body.

Systemic lupus erythematosus: A chronic inflammatory condition caused by an autoimmune disease. An autoimmune disease occurs when the body's tissues are attacked by its own immune system. Patients with lupus have unusual antibodies in their blood that are targeted against their own body tissues.
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Therapy: The treatment of disease.
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Thrombocytopenia: A low platelet count. Platelets are irregular, disc-shaped element in the blood that assists in blood clotting. thrombocytopenia can arise due to decreased production of platelets in the bone marrow or increased breakdown of platelets in the bloodstream, spleen, or liver. Thrombocytopenia is characterized by easy bruising and increased bleeding.

Thrombosis: The formation or presence of a blood clot in a blood vessel. The vessel may be any vein or artery as, for example, in a deep vein thrombosis or a coronary (artery) thrombosis. The clot itself is termed a thrombus. If the clot breaks loose and travels through the bloodstream, it is a thromboembolism. Thrombosis, thrombus, and the prefix thrombo- all come from the Greek thrombos meaning a lump or clump, or a curd or clot of milk. See entries also to: Cavernous sinus thrombosis; Renal vein thrombosis. And see: Deep Vein Thrombosis and Pulmonary Embolism.

Topical: Pertaining to a particular surface area. A topical agent is applied to a certain area of the skin and is intended to affect only the area to which it is applied. Whether its effects are indeed limited to that area depends upon whether the agent stays where it is put or is absorbed into the blood stream.

Trigger: Something that either sets off a disease in people who are genetically predisposed to developing the disease, or that causes a certain symptom to occur in a person who has a disease. For example, sunlight can trigger rashes in people with lupus.

Urine: Liquid waste. The urine is a clear, transparent fluid. It normally has an amber color. The average amount of urine excreted in 24 hours is from 40 to 60 ounces (about 1,200 cubic centimeters). Chemically, the urine is mainly an aqueous (watery) solution of salt (sodium chloride) and substances called urea and uric acid. Normally, it contains about 960 parts of water to 40 parts of solid matter. Abnormally, it may contain sugar (in diabetes), albumen (a protein) (as in some forms of kidney disease), bile pigments (as in jaundice), or abnormal quantities of one or another of its normal components.

Warfarin: An anticoagulant drug (brand names: Coumarin, Panwarfin, Sofarin) taken to prevent the blood from clotting and to treat blood clots and overly thick blood. Warfarin is also used to reduce the risk of clots causing strokes or heart attacks.
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