Lupus (Systemic Lupus Erythematosus): Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by periods of remission and relapse (flares). Symptoms and signs include fatigue, fever, rash, abdominal pain, depression, and muscle pain. Treatment involves using high SPF lotion to prevent sun-induced rashes and may involve taking medications such as hydroxychloroquine, chloroquine, antidepressant, or heparin.