Migraine and Cluster Headache Medications (cont.)
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What Causes Migraine and Cluster Headaches?
Many experts believe that migraine and cluster headaches share a common cause that begins in the nerve that carries sensation from the head to the brain (trigeminal nerve). Blood vessels on the brain’s surface expand (dilate), causing swelling in an area and pressure on nerve endings. The nerve endings submit signals to the brain to perceive pain. This may also explain some other symptoms associated with migraines, such as nausea, vomiting, and visual disturbances.
Mary L Windle, PharmD
Joseph Carcione Jr, DO, MBA
Francisco Talavera, PharmD, PhD
James H Halsey, MD
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Although migraine is a term applied to certain headaches with a vascular quality, overwhelming evidence suggests that migraine is a dominantly inherited disorder characterized by varying degrees of recurrent vascular-quality headache, photophobia, sleep disruption, and depression.