• Topic Overview
• Related Information
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Topic Overview

Pain is a frequent problem for people who have multiple sclerosis (MS). Medicines that may be used to bring relief include:

• Nonprescription pain relievers. These include acetaminophen (such as Tylenol), ibuprofen (such as Advil), and naproxen (such as Aleve).
• Amitriptyline, imipramine (Tofranil), or nortriptyline (Pamelor), for burning sensations.
• Carbamazepine (Tegretol).
• Gabapentin (Neurontin). This drug may also help relieve muscle stiffness and tightness (spasticity).
• Phenytoin (Dilantin).
• Pregabalin (Lyrica).

Pain that does not respond to these medicines can sometimes be treated with an injection of long-acting anesthetic.

Related Information

• Multiple Sclerosis (MS)
• Pain Management

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