Wendy Hu, MD
Clarence Sarkodee-Adoo, MD
Mary L Windle, PharmD
Jay B. Zatzkin, MD
IN THIS ARTICLE
Myeloma Medications and Other Drug Therapy
Numerous chemotherapy and biological drug combinations have been used for multiple myeloma. Which type and combination of therapy depends on many factors, including the type and stage of myeloma, the ability to tolerate chemotherapy side effects, and if any previous treatment was rendered or if further treatment is planned, such as stem cell transplantation. Hematologists/oncologists often work together regionally to decide which combination of chemotherapy and biological drugs are currently working best for their patients. Because of this regional collaboration, the drug combinations often vary and are able to change rapidly when improved results occur.
Chemotherapy is given in cycles.
Chemotherapy may be given in pill form or in liquid form to be infused directly into the bloodstream through a vein (intravenous).
Other drug therapy
Other drugs that are standard treatments for myeloma are corticosteroids (prednisone or dexamethasone) and thalidomide (Thalomid) and lenalidomide (Revlimid).
Corticosteroids are powerful drugs that have many different actions, including anti-inflammatory and anti-immunity activity. They are active against myeloma and reduce production of the M protein. Prednisone and dexamethasone can be given with chemotherapy agents or alone for people who cannot tolerate chemotherapy drugs or need them to help to lower calcium levels or to reduce swelling around nerves being pressed upon by masses of plasma cells in or next to bones.
Immune system modifying drugs such as thalidomide or lenalidomide are not chemotherapy agents in the traditional sense. These immunomodulatory agents are usually given with a corticosteroid, such as dexamethasone (Decadron). Thalidomide's actions may include decreasing the ability of cancer spread throughout the blood (antiangiogenesis), interfering with adhesion molecules, or enhancing release of cytokines (cancer-fighting substances within the body). This drug may be associated with sleepiness, constipation, venous blood clots, and numbness and tingling in the tips of the extremities. It is absolutely contraindicated in pregnancy, as it causes birth defects. The drug is dispensed through a program that ensures that physicians have educated patients about the importance of contraception when taking the drug. Usually, aspirin or low-dose blood thinners, such as warfarin (Coumadin) are given in conjunction with thalidomide and corticosteroids.
New drug therapy
An analogue of thalidomide, CC-5013, or lenalidomide (Revlimid), purportedly has fewer side effects of thalidomide and appears to be more potent than thalidomide in laboratory studies. It is also an immunomodulatory agent, which has undergone early clinical evaluation for recurrent myeloma and newly diagnosed myeloma with encouraging results. Further clinical evaluation is necessary and ongoing. It has been evaluated as part of combined therapy with corticosteroids or chemotherapy drugs. Currently, other immunomodulatory drugs for myeloma are also undergoing development.
Bortezomib (Velcade) is the first of a new class of medicines called proteasome inhibitors. Proteasome inhibitors may preferentially disrupt a cancer cell's growth. Other proteasome inhibitors have recently been developed and are now undergoing early clinical evaluation.
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