Norovirus Glossary of Terms

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Abdominal: Relating to the abdomen, the belly, that part of the body that contains all of the structures between the chest and the pelvis. The abdomen is separated anatomically from the chest by the diaphragm, the powerful muscle spanning the body cavity below the lungs.
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Antibody: An immunoglobulin, a specialized immune protein, produced because of the introduction of an antigen into the body, and which possesses the remarkable ability to combine with the very antigen that triggered its production.
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Atropine: A drug obtained from belladonna that is administered via injection, eye drops, or in oral form to relax muscles by inhibiting nerve responses. Used to dilate the pupils and as an antispasmodic.
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Caliciviridae: See: Calicivirus; Norovirus.

Capsid: The protein coat of a virus. The term capsid came in 1960 from the French capside, from the Latin capsa, case. See also: Nucleocapsid.

CDC: The Centers for Disease Control and Prevention, the US agency charged with tracking and investigating public health trends. The stated mission of the CDC is "To promote health and quality of life by preventing and controlling disease, injury, and disability." The CDC is a part of the U.S. Public Health Services (PHS) under the Department of Health and Human Services (HHS).
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Chills: feelings of coldness accompanied by shivering. Chills may develop after exposure to a cold environment or may accompany a fever.

Clinical trials: Trials to evaluate the effectiveness and safety of medications or medical devices by monitoring their effects on large groups of people.
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Cluster: In epidemiology, an aggregation of cases of a disease or another health-related condition, such as a cancer or birth defect, closely grouped in time and place. The number of cases in the cluster may or may not exceed the expected number. This is determined by cluster analysis, a set of statistical methods used to analyze clusters.

Coma: A state of deep unarousable unconsciousness.
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Dehydration: Excessive loss of body water. Diseases of the gastrointestinal tract that cause vomiting or diarrhea may, for example, lead to dehydration. There are a number of other causes of dehydration including heat exposure, prolonged vigorous exercise (e.g., in a marathon), kidney disease, and medications (diuretics).
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Diarrhea: A familiar phenomenon with unusually frequent or unusually liquid bowel movements, excessive watery evacuations of fecal material. The opposite of constipation. The word "diarrhea" with its odd spelling is a near steal from the Greek "diarrhoia" meaning "a flowing through." Plato and Aristotle may have had diarrhoia while today we have diarrhea. There are myriad infectious and noninfectious causes of diarrhea.
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Discharge: 1.The flow of fluid from part of the body, such as from the nose or vagina.
2. The passing of an action potential, such as through a nerve or muscle fiber.
3. The release of a patient from a course of care. The doctor may then dictate a discharge summary.

Electrolyte: An electrolyte is a substance that will dissociate into ions in solution and acquire the capacity to conduct electricity. The electrolytes include sodium, potassium, chloride, calcium and phosphate. Informally, called lytes. (The clue to the word electrolyte is in the lyte which comes from the Greek lytos meaning that may be dissolved.)

Electron microscopy: Abbreviated EM. Microscopy in which an electron beam replaces light to form the image.
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ELISA: ELISA stands for "enzyme-linked immunosorbent assay." This is a rapid immunochemical test that involves an enzyme (a protein that catalyzes a biochemical reaction). It also involves an antibody or antigen (immunologic molecules).
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Epidemic: The occurrence of more cases of a disease than would be expected in a community or region during a given time period. A sudden severe outbreak of a disease such as SARS. From the Greek "epi-", "upon" + "demos", "people or population" = "epidemos" = "upon the population." See also: Endemic; Pandemic.

Esophageal: Pertaining to the esophagus.

Feces: The medical and scientific term for the "excrement discharged from the intestines."
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Fever: Although a fever technically is any body temperature above the normal of 98.6 degrees F. (37 degrees C.), in practice a person is usually not considered to have a significant fever until the temperature is above 100.4 degrees F (38 degrees C.).
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Flu: Short for influenza. The flu is caused by viruses that infect the respiratory tract which are divided into three types, designated A, B, and C. Most people who get the flu recover completely in 1 to 2 weeks, but some people develop serious and potentially life-threatening medical complications, such as pneumonia. Much of the illness and death caused by influenza can be prevented by annual influenza vaccination.

Gastroenteritis: Inflammation of the stomach and the intestines. Can cause nausea and vomiting and/or diarrhea. Gastroenteritis has numerous causes: including infectious organisms (viruses, bacteria, etc.), food poisoning, and stress.

Gastrointestinal: Adjective referring collectively to the stomach and small and large intestines.
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Gastrointestinal tract: The tube that extends from the mouth to the anus in which the movement of muscles and release of hormones and enzymes digest food. The gastrointestinal tract starts with the mouth and proceeds to the esophagus, stomach, duodenum, small intestine, large intestine (colon), rectum and, finally, the anus. Also called the alimentary canal, digestive tract and, perhaps most often in conversation, the GI tract.

Genetic: Having to do with genes and genetic information.

Genome: All of the genetic information, the entire genetic complement, all of the hereditary material possessed by an organism.
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Headache: A pain in the head with the pain being above the eyes or the ears, behind the head (occipital), or in the back of the upper neck. Headache, like chest pain or back ache, has many causes.
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Hygiene: The science of preventive medicine and the preservation of health. From the name of Hygeia, the daughter of Asklepios, the Greek god of medicine (whose staff with entwined snake is the symbol of medicine). Asklepios (known to the Romans as Aesculapius) had a number of children including not only Hygeia but also Panaceia, the patroness of clinical medicine. Hygeia also followed her father into medicine. As the patroness of health, Hygeia was charged with providing a healthy environment to prevent illness. In Greek, "hygieia" means health.

Immune: Protected against infection. The Latin immunis means free, exempt.

Immunocompromised: Having an immune system that has been impaired by disease or treatment.

Infection: The growth of a parasitic organism within the body. (A parasitic organism is one that lives on or in another organism and draws its nourishment therefrom.) A person with an infection has another organism (a "germ") growing within him, drawing its nourishment from the person.
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Influenza: The flu is caused by viruses that infect the respiratory tract which are divided into three types, designated A, B, and C. Most people who get the flu recover completely in 1 to 2 weeks, but some people develop serious and potentially life-threatening medical complications, such as pneumonia. Much of the illness and death caused by influenza can be prevented by annual influenza vaccination.

Lethargy: 1. Abnormal drowsiness, stupor. 2. A state of indifference.
From the Greek lethargia, drowsiness.

Liter: A metric measure of capacity that, by definition, is equal to the volume of a kilogram of water at 4 degrees centigrade and at standard atmospheric pressure of 760 millimeters of mercury.

• Metric equivalents -- There are 1000 cubic centimeters or 1 cubic decimeter in 1 liter.
• U.S. equivalent -- A liter is a little more than a quart (1.057 U.S. liquid quarts).

Microscopy: The examination of minute objects by means of a microscope, an instrument which provides an enlarged image of an object not visible with the naked eye.
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Muscle: Muscle is the tissue of the body which primarily functions as a source of power. There are three types of muscle in the body. Muscle which is responsible for moving extremities and external areas of the body is called "skeletal muscle." Heart muscle is called "cardiac muscle." Muscle that is in the walls of arteries and bowel is called "smooth muscle."

Nasal: Having to do with the nose. Nasal drops are intended for the nose, not (for example) the eyes. The word "nasal" came from the Latin "nasus" meaning the nose or snout.

Nausea: Nausea, is the urge to vomit. It can be brought by many causes including, systemic illnesses, such as influenza, medications, pain, and inner ear disease. When nausea and/or vomiting are persistent, or when they are accompanied by other severe symptoms such as abdominal pain, jaundice, fever, or bleeding, a physician should be consulted.

Norovirus: A group of viruses that are a common cause of food poisoning and acute gastroenteritis ("stomach flu") that can strike quickly with force and make a person feel very sick but which typically resolves within 2-3 days. The characteristic symptoms are nausea, vomiting, diarrhea, and abdominal cramping. The diarrhea is not bloody. Fever, if present, is low-grade. Dehydration is the main complication, especially in infants and the elderly, and may need medical attention.
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Norwalk virus: A family of small round viruses that are an important cause of viral gastroenteritis (viral inflammation of the stomach and intestines). Norwalk disease is a significant contributor to illness in the US. Only the common cold is reported more frequently as a cause of disease. About a third of all cases of viral gastroenteritis after infancy are due to Norwalk viruses.
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Norwalk-like virus: See: Norovirus.

Nursing: 1) Profession concerned with the provision of services essential to the maintenance and restoration of health by attending the needs of sick persons. 2) Feeding a infant at the breast.

Onset: In medicine, the first appearance of the signs or symptoms of an illness as, for example, the onset of rheumatoid arthritis. There is always an onset to a disease but never to the return to good health. The default setting is good health.
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Oral rehydration salts: ORS. A solution of glucose-based salt solution used in oral rehydration therapy. WHO and UNICEF recommend a single formulation of glucose-based ORS to treat or prevent dehydration from diarrhea from any cause, including cholera, and in individuals of any age. In technical terms, this ORS solution contains 75 mEq/l of sodium and 75 mmol/l of glucose, and have a total osmolarity of 245 mOsm/l.

Pathogenesis: The development of a disease. The origin of a disease and the chain of events leading to that disease.

Pediatric: Pertaining to children.

Potassium: The major positive ion (cation) found inside of cells. The chemical notation for potassium is K⁺.
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Pregnant: The state of carrying a developing fetus within the body.
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Rehydrate: To restore lost water to the body tissues and fluids. Prompt rehydration is imperative whenever dehydration occurs, from diarrhea, exposure, lack of drinking water, or medication use. Rehydration can be by oral or IV administration of fluids.

Rehydration: The process of restoring lost water to the body tissues and fluids. Prompt rehydration is imperative whenever dehydration occurs, from diarrhea, exposure, lack of drinking water, or medication use. Rehydration can be by the oral route or by the intravenous administration of fluids.

Replication: A turning back, repetition, duplication, reproduction.

Reverse transcriptase: The enzyme that permits the human immunodeficiency virus (HIV) and other retroviruses to use their viral RNA as a template to make DNA.
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RNA: Short for ribonucleic acid, a nucleic acid molecule similar to DNA but containing ribose rather than deoxyribose. RNA is formed upon a DNA template. There are several classes of RNA molecules.
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Rotavirus (RV): A leading cause of severe winter diarrhea in young children, RV each year causes an estimated 500,000 doctor visits and 50,000 hospital admissions in the United States. Almost everyone catches RV before entering school but, with rehydration (and good nutrition), nearly all recover fully. However, in poor countries it is estimated that there are at least 600,000 deaths of children under 5 years from RV diarrhea and dehydration.
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RT-PCR (Reverse transcriptase-polymerase chain reaction): a highly sensitive technique for the detection and quantitation of mRNA (messenger RNA). The technique consists of two parts:

1. The synthesis of cDNA (complementary DNA) from RNA by reverse transcription (RT) and
2. The amplification of a specific cDNA by the polymerase chain reaction (PCR).

Rule out: A term much used in medicine, meaning to eliminate or exclude something from consideration. The ACB (albumin cobalt binding) test helps rule out a heart attack in the differential diagnosis of severe chest pain.

Serum: The clear liquid that can be separated from clotted blood. Serum differs from plasma, the liquid portion of normal unclotted blood containing the red and white cells and platelets. It is the clot that makes the difference between serum and plasma.
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Stomach: 1. The sac-shaped digestive organ that is located in the upper abdomen, under the ribs. The upper part of the stomach connects to the esophagus, and the lower part leads into the small intestine.
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Stomach flu: So-called "stomach flu" actually has nothing to do with the influenza (flu) virus. This term is sometimes used to describe gastrointestinal illnesses caused by other microorganisms.

Stool: The solid matter discharged in a bowel movement.

Symptom: Any subjective evidence of disease. Anxiety, lower back pain, and fatigue are all symptoms. They are sensations only the patient can perceive. In contrast, a sign is objective evidence of disease. A bloody nose is a sign. It is evident to the patient, doctor, nurse and other observers.

Taste: Taste belongs to our chemical sensing system, or the chemosenses. The complicated process of tasting begins when molecules released by the substances stimulate special cells in the mouth or throat. These special sensory cells transmit messages through nerves to the brain where specific tastes are identified.
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Teaspoon: An old-fashioned but convenient household measure. A teaspoon holds about 5 cc of liquid.

Tired: A feeling of a lessened capacity for work and reduced efficiency of accomplishment, usually accompanied by a sense of weariness and fatigue.
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Vibrio: A group of bacteria that includes Vibrio cholerae, the agent of cholera, (a devastating and sometimes lethal disease with profuse watery diarrhea) and Vibrio comma (which is shaped like a comma). Vibrio move about actively . The word "vibrio" in Latin means "to quiver."

Viral: Of or pertaining to a virus. For example, "My daughter has a viral rash."

Viral infection: Infection caused by the presence of a virus in the body. Depending on the virus and the person's state of health, various viruses can infect almost any type of body tissue, from the brain to the skin. Viral infections cannot be treated with antibiotics; in fact, in some cases the use of antibiotics makes the infection worse. The vast majority of human viral infections can be effectively fought by the body's own immune system, with a little help in the form of proper diet, hydration, and rest. As for the rest, treatment depends on the type and location of the virus, and may include anti-viral or other drugs.

Virus: A microorganism smaller than a bacteria, which cannot grow or reproduce apart from a living cell. A virus invades living cells and uses their chemical machinery to keep itself alive and to replicate itself. It may reproduce with fidelity or with errors (mutations)-this ability to mutate is responsible for the ability of some viruses to change slightly in each infected person, making treatment more difficult.
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Viruses: Small living particles that can infect cells and change how the cells function. Infection with a virus can cause a person to develop symptoms. The disease and symptoms that are caused depend on the type of virus and the type of cells that are infected.

Vomit: Matter from the stomach that has come up into and may be ejected beyond the mouth, due to the act of vomiting.
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