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February 8, 2012
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Sleep Apnea

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Sleep Apnea Overview

Sleep apnea is a common condition characterized by a periodic reduction in or a complete stop of breathing during sleep. There are two main types of sleep apnea; obstructive sleep apnea (OSA) and central sleep apnea (CSA). Mixed sleep apnea refers to the combination of both central and obstructive sleep apnea.

Apnea is defined as a cessation or near-cessation of breathing for 10 seconds or more that results in a reduction of airflow to 25% below normal. A less severe reduction in breathing is called hypopnea.

The basic underlying mechanism is different for the types of sleep apnea. Normally, the brain sends a signal to the respiratory muscles to expand and bring air into the lungs. In central sleep apnea, the brain fails to send this signal appropriately, causing disrupted and unregulated breathing. In obstructive sleep apnea, the brain sends appropriate signals and the muscles try to expand to initiate breathing, however, the flow of air into the lungs is obstructed, causing reduced breathing and airflow into the lungs.

In general, sleep apnea is rare in children. It becomes more prevalent with increasing age and it is more common in men than women. Obstructive sleep apnea is more common than central sleep apnea. It is estimated that about 25% of adults are at risk for developing obstructive sleep apnea. It is also estimated that up to 4% of adults may have central sleep apnea. These conditions remain somewhat under-diagnosed in the general population.

Sleep apnea may lead to disrupted sleep, daytime sleepiness, and insomnia. If untreated, sleep apnea may contribute to other medical conditions, such as high blood pressure (hypertension), congestive heart failure, pulmonary hypertension, heart disease, strokes, or even death.

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Circadian Rhythm Disorder Overview

A person's circadian rhythm is anÂinternal biological clock that regulates a variety of biological processes according to an approximate 24-hour period. Most of a person's bodyÂsystems demonstrate circadian variations. The body systems with the most prominent circadian variations are the sleep-wake cycle, the temperature regulation system, and the endocrine system.

The malfunctioning of a person's circadian system, or biological clock, causes circadian rhythm disorders. The circadian rhythm disorder related to the sleep-wake cycle can be categorized into the following 2 main groups:

  • Transient disorders

    • Jet lag

    • Altered sleep schedule due to work hours or social responsibilities Â

    • Illness
      Â
  • Chronic disorders

    • Delayed sleep-phase syndrome (DSPS)ÂÂ

      • DSPS is characterized by a persistent (that is, lasting lon...


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