Dr. Eck received a Bachelor of Science degree from the Catholic University of America in Biomedical Engineering, followed by a Master of Science degree in Biomedical Engineering from Marquette University. Following this he worked as a research engineer
Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.
Paget's disease of the bone is the second most common bone disorder in elderly patients. (Osteoporosis is the most common.) Paget's disease
is a disorder that affects the normal remodeling process of bone. In normal bone, the bone constantly remodels. In the remodeling process, old bone is removed and new bone is formed. In patients
with Paget's disease, this process is altered. These patients have an excessive amount of bone resorption (removal) followed by an even more
excessive amount of new bone formation. Unfortunately, this increased rate of bone remodeling leads to new bone that is not as strong as normal bone. This abnormal bone is weaker, has more blood vessels, and is larger in size than normal bone. While most cases do not cause symptoms, some patients may
develop pain, fractures, or even malignant transformation into sarcoma (bone tumor), although this is rare.
Men are affected by Paget's disease slightly more often than women (3:2 male-to-female ratio). Paget's disease is more common in patients of Northern European ancestry, most commonly in those from
Great Britain. It is rare in Asia and Africa. It is more common with increasing age, typically diagnosed in people in their 50s. Up to three million people in the United States are estimated to
have Paget's disease.
Most people who have Paget's disease have no symptoms. Most often Paget's disease is discovered when you see your doctor for a different reason, such as hip pain. A bone X-ray or abnormal blood test often leads to the discovery of Paget's disease.