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Paget's Disease

Paget's Disease Overview

Paget's disease of the bone is the second most common bone disorder in elderly patients. (Osteoporosis is the most common.) Paget's disease is a disorder that affects the normal remodeling process of bone. In normal bone, the bone constantly remodels. In the remodeling process, old bone is removed and new bone is formed. In patients with Paget's disease, this process is altered. These patients have an excessive amount of bone resorption (removal) followed by an even more excessive amount of new bone formation. Unfortunately, this increased rate of bone remodeling leads to new bone that is not as strong as normal bone. This abnormal bone is weaker, has more blood vessels, and is larger in size than normal bone. Paget's disease is also called osteitis deformans. While most cases do not cause symptoms, some patients may develop bone pain, fractures, deformities, and sometimes malignant transformation into sarcoma (bone tumor), although this is rare.

Men are affected by Paget's disease slightly more often than women. Paget's disease is more common in people of Northern European ancestry, most commonly in those from Great Britain. It is rare in Asia and Africa. It is more common with increasing age, typically diagnosed in people in their 50s. In the United States, a small percent of the general population is estimated to have Paget's disease.

Medically Reviewed by a Doctor on 1/7/2015
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Patient Comments & Reviews

The eMedicineHealth doctors ask about Paget's Disease:

Paget's Disease - Symptoms

The symptoms of Paget's disease vary from patient to patient. What were the symptoms at the onset of your disease?

Paget's Disease - Diagnosis

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Paget's Disease - Effective Treatment

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Paget's Disease Diagnosis

Most people who have Paget's disease have no symptoms. Most often Paget's disease is discovered when you see your doctor for a different reason, such as hip pain. A bone X-ray or abnormal blood test often leads to the discovery of Paget's disease.



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Paget Disease »

Paget's disease (Paget disease), characterized by excessive and abnormal remodeling of bone, is a common disorder in middle-aged and elderly patients.

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