Paget Disease (cont.)
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Paget's Disease Diagnosis
Laboratory studies include both blood and urine studies. Bone-specific alkaline phosphatase is a specific laboratory study that provides information on the rate of bone turnover, which is increased in people with Paget's disease. Other laboratory studies include assessment of calcium, phosphate, and parathyroid hormone levels. In many cases, these levels remain normal. Urine tests include procollagen type I N-terminal propeptide (PINP), serum C-telopeptide (CTx), urinary N-telopeptide (NTx), and urinary hydroxyproline, which measure bone degradation products secreted in the urine. These studies may be useful in both diagnosis and long-term monitoring of the disease process and response to medical treatment.
Radiographic studies are often limited to plain radiographs (X-ray films). Early in the disease process, osteolysis, or softening and destruction of bone mass, is seen on X-ray films. Later in the course of the disease, there is increased bone mass, or sclerosis. Radiographs are also necessary if fracture is suspected. Radiographs should also be used to evaluate for possible malignant transformation.
Bone scans are useful in assessing the extent of disease throughout the entire body.
CT scan and magnetic resonance imaging (MRI) can be useful in the evaluation of patients with neurologic dysfunction or muscle weakness to assess for involvement of the spine and compression of the spinal cord or nerve roots. Rarely, a bone biopsy is required, especially if malignancy is suspected.
Paget's Disease Treatment
Most people with Paget's disease do not have symptoms. Treatment in such patients would be based on the location of the pagetic bone or if the alkaline phosphatase level is elevated two to four times the normal limits. People with symptoms are treated in various ways.
Medically Reviewed by a Doctor on 7/22/2014
Mythili Seetharaman, MD
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