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Paget Disease (cont.)

Medical Treatment

Patient Comments

Medical treatment is geared toward pain relief and reducing the amount of bone turnover with medications.

Paget's Disease Medications

The following oral medications may be prescribed by your doctor to control bone or joint pain related to Paget's disease:

  • Nonsteroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen (Motrin, Advil) or naproxen (Naprosyn, Aleve)
  • Bisphosphonates inhibit excessive bone loss. Examples of these medications and typical doses for Paget's disease are

For people who do not tolerate oral bisphosphonates, intranasal calcitonin is a reasonable alternative to inhibit bone loss. Pamidronate (Aredia) and zoledronic acid (Reclast, Zometa) are intravenous forms of bisphosphonate that could be used when oral therapy is not possible.

The following are specific instructions for taking bisphosphonates and are important to assure proper absorption by the body. Beverages other than plain water (including mineral water), food, and some medications are likely to reduce the absorption of bisphosphonates. Take first thing upon awakening in the morning before other medications and food. Do not take within 30 minutes of consuming food. Take antacids, calcium, vitamin, and mineral supplements, at least two hours after bisphosphonates. Additionally, sit upright or stand for 30 minutes to avoid erosion to your esophagus.

Serum alkaline phosphatase levels are monitored to determine duration of treatment as well as to monitor disease activity and need for retreatment.

Medically Reviewed by a Doctor on 7/22/2014
Medical Author:

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Patient Comments & Reviews

The eMedicineHealth doctors ask about Paget's Disease:

Paget's Disease - Symptoms

The symptoms of Paget's disease vary from patient to patient. What were the symptoms at the onset of your disease?

Paget's Disease - Effective Treatment

What treatment has been effective for your Paget's disease?

Paget's Disease - Diagnosis

Please describe your Paget's disease diagnosis.





Read What Your Physician is Reading on Medscape

Paget Disease »

Paget's disease (Paget disease), characterized by excessive and abnormal remodeling of bone, is a common disorder in middle-aged and elderly patients.

Read More on Medscape Reference »


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