Paget Disease (cont.)
IN THIS ARTICLE
Exams and Tests
Laboratory studies include both blood and urine studies. Bone-specific alkaline phosphatase is a specific laboratory study that provides information on the rate of bone turnover, which is increased in people with Paget's disease. Other laboratory studies include assessment of calcium, phosphate, and parathyroid hormone levels. In many cases, these levels remain normal. Urine tests include N-telopeptides and deoxypyridinoline, which measure bone degradation products secreted in the urine. These studies may be useful in both diagnosis and long-term monitoring of the disease progress and response to medical treatment.
Radiographic studies are often limited to plain radiographs (x-ray films). Early in the disease process, osteolysis, or softening and destruction of bone mass, is seen on x-ray films. Later in the course of the disease, there is increased bone mass, or sclerosis. Radiographs are also necessary if fracture is suspected. Radiographs should also be used to evaluate for possible malignant transformation.
Bone scans are useful in assessing the extent of disease throughout the entire skeleton.
Magnetic resonance imaging (MRI) can be useful in the evaluation of patients with neurologic dysfunction or muscle weakness to assess for involvement of the spine and compression of the spinal cord or nerve roots.
Must Read Articles Related to Paget Disease
Patient Comments & Reviews
The eMedicineHealth doctors ask about Paget Disease:
Paget's Disease - Symptoms
The symptoms of Paget's disease vary from patient to patient. What were the symptoms at the onset of your disease?
Paget's Disease - Effective Treatment
What symptoms did you experience with Paget's Disease?
Paget's Disease - Diagnosis
How was your Paget's disease diagnosed?