Paget Disease (cont.)
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Paget's Disease Medications
The following oral medications may be prescribed by your doctor to control bone or joint pain related to Paget's disease:
For people who do not tolerate oral bisphosphonates, intranasal calcitonin is a reasonable alternative to inhibit bone loss. Pamidronate and zoledronic acid are intravenous forms of bisphosphonate that could be used when oral therapy is not possible.
The following are specific instructions for taking bisphosphonates and are important to assure proper absorption by the body. Beverages other than plain water (including mineral water), food, and some medications are likely to reduce the absorption of bisphosphonates. Take first thing upon awakening in the morning before other medications and food. Do not take within 30 minutes of consuming food. Take antacids, calcium, vitamin, and mineral supplements, at least two hours after bisphosphonates. Additionally, sit upright or stand for 30 minutes to avoid erosion to your esophagus.
Serum alkaline phosphatase levels are monitored to determine duration of treatment as well as to monitor disease activity and need for retreatment.
Mythili Seetharaman, MD
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