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Paget Disease (cont.)

Medications

The following oral medications may be prescribed by your doctor to control bone or joint pain related to Paget disease:

  • Nonsteroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen (Motrin, Advil) or naproxen (Naprosyn, Aleve)
  • Bisphosphonates inhibit excessive bone loss. Examples of these medications and typical doses for Paget's disease are:

For people who do not tolerate oral bisphosphonates, injectable calcitonin (a subcutaneous injection administered at home) is a reasonable alternative to inhibit bone loss. Pamidronate, an intravenous form of bisphosphonate, is an expensive alternative that is appropriate when oral therapy is not possible.

The following are specific instructions for taking bisphosphonates and are important to assure proper absorption by the body. Beverages other than plain water (including mineral water), food, and some medications are likely to reduce the absorption of bisphosphonates. Take first thing upon wakening in the morning before other medications and food. Do not take within 30 minutes of consuming food. Take antacids, calcium, vitamin, and mineral supplements, at least two hours after bisphosphonates. Additionally, sit upright or stand for 30 minutes to avoid erosion to your esophagus (throat).

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Patient Comments & Reviews

The eMedicineHealth doctors ask about Paget Disease:

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Read What Your Physician is Reading on Medscape

Paget Disease »

Paget's disease (Paget disease), characterized by excessive and abnormal remodeling of bone, is a common disorder in middle-aged and elderly patients.

Read More on Medscape Reference »


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