Pain Medications Glossary of Medical Terms

Acetaminophen: A pain reliever and fever reducer. Brand name: Tylenol. The exact mechanism of action of acetaminophen is not known. Acetaminophen relieves pain by elevating the pain threshold (that is, by requiring a greater amount of pain to develop before it is felt by a person). Acetaminophen reduces fever through its action on the heat-regulating center (the "thermostat") of the brain. Generic is available.
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Acute: Of abrupt onset, in reference to a disease. Acute often also connotes an illness that is of short duration, rapidly progressive, and in need of urgent care.
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Acute pain: Pain that comes on quickly, can be severe, but lasts a relatively short time. As opposed to chronic pain .
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Addiction: A chronic relapsing condition characterized by compulsive drug-seeking and abuse and by long-lasting chemical changes in the brain . Addiction is the same irrespective of whether the drug is alcohol , amphetamines, cocaine , heroin , marijuana , or nicotine . Every addictive substance induces pleasant states or relieves distress. Continued use of the addictive substance induces adaptive changes in the brain that lead to tolerance, physical dependence, uncontrollable craving and, all too often, relapse . Dependence is at such a point that stopping is very difficult and causes severe physical and mental reactions from withdrawal. The risk of addiction is in part inherited. Genetic factors, for example, account for about 40% of the risk of alcoholism . The genetic factors predisposing to addiction are not yet fully understood.
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Aleve: See: Naproxen .
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Analgesia: The inability to feel pain while still conscious. From the Greek an-, without + algesis, sense of pain.
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Analgesic: A drug or medicine given to reduce pain without resulting in loss of consciousness. Analgesics are sometimes referred to as painkiller medications. There are many different types of analgesic medications available in both prescription and over-the-counter preparations. Examples of analgesic drugs include aspirin , acetaminophen (Tylenol), ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), the COX-2 inhibitor celecoxib , and narcotic drugs including morphine, oxycodone , and hydrocodone (Vicodin). Analgesics may also be combined with other drugs in some types of medications (for example, analgesics are combined with decongestants and/or antihistamine in many over-the-counter cold remedies).
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Ankle: The ankle joint is complex. It is made up of two joints: the true ankle joint and the subtalar joint:
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Ankle sprain: A common musculoskeletal injury in which the ligaments of the ankle partially or completely tear due to sudden stretching. This typically occurs when the ankle is suddenly "twisted" in a sports activity or by stepping off an uneven surface. The pain is initially severe and can be associated with a "popping" sensation. Immediate swelling over the area of injury often occurs as the injured blood vessels leak fluid into the local tissue. Partial tears retain some ankle stability, whereas complete tears lose stability because the strapping ligaments no longer brace the ankle joint .
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Antihypertensive: Something that reduces high blood pressure (hypertension).
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Aspirin: A good example of a tradename that entered into the language, Aspirin was once the Bayer trademark for acetylsalicylic acid .
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NOTE: April 7, 2005, Pfizer agreed to suspend sales and marketing of Bextra in the U.S., pending further discussions with the with the FDA. For more information, please read the FDA press release.
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Blood clots: Blood that has been converted from a liquid to a solid state. Also called a thrombus.
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Brain: That part of the central nervous system that is located within the cranium ( skull ). The brain functions as the primary receiver, organizer and distributor of information for the body. It has two (right and left) halves called "hemispheres."
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Breathing: The process of respiration, during which air is inhaled into the lungs through the mouth or nose due to muscle contraction, and then exhaled due to muscle relaxation.
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Bumps: The raised area of a bump or bruise results from blood leaking from these injured blood vessels into the tissues as well as from the body's response to the injury. A purplish, flat bruise that occurs when blood leaks out into the top layers of skin is referred to as an ecchymosis.
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Bypass: An operation in which a surgeon creates a new tubular pathway for the movement of fluids and/or other substances in the body.
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Cancer: An abnormal growth of cells which tend to proliferate in an uncontrolled way and, in some cases, to metastasize (spread).
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Cardiac: Having to do with the heart.
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Cardiovascular: The circulatory system comprising the heart and blood vessels which carries nutrients and oxygen to the tissues of the body and removes carbon dioxide and other wastes from them.
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Cerebrospinal fluid: CSF. A watery fluid, continuously produced and absorbed, which flows in the ventricles (cavities) within the brain and around the surface of the brain and spinal cord.
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Chills: feelings of coldness accompanied by shivering. Chills may develop after exposure to a cold environment or may accompany a fever .
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Chronic: This important term in medicine comes from the Greek chronos, time and means lasting a long time.
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Chronic pain : Pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. In contrast to acute pain that arises suddenly in response to a specific injury and is usually treatable, chronic pain persists over time and is often resistant to medical treatments.
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Clinical trial: See: Clinical trials . See also: Inconclusive clinical trial ; Negative clinical trial ; Non-inferior clinical trial ; Positive clinical trial .
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Constipation: Infrequent (and frequently incomplete) bowel movements. The opposite of diarrhea , constipation is commonly caused by irritable bowel syndrome, diverticulosis , and medications (constipation can paradoxically be caused by overuse of laxatives). Colon cancer can narrow the colon and thereby cause constipation. The large bowel (colon) can be visualized by barium enema x-rays, sigmoidoscopy, and colonoscopy. Barring a condition such as cancer, high-fiber diets can frequently relieve the constipation.
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Cox-2: Cyclooxygenase-2, a protein acts as an enzyme and specifically catalyzes (speeds) the production of certain chemical messengers called prostaglandins. Some of these messengers are responsible for promoting inflammation. When Cox-2 activity is blocked, inflammation is reduced. Unlike cox-1, cox-2 is active only at the site of inflammation, not in the stomach.
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Cox-2 inhibitor: A type of drug that selectively blocks the enzyme cox-2 (cyclooxygenase-2). Blocking this enzyme impedes the production of the chemical messengers called prostaglandins that cause the pain and swelling of arthritis inflammation. Cox-2 inhibitors may not pose as great a risk of injuring the stomach or intestines as cox-1 inhibitors. Cox-2 inhibitors now on the market include celecoxib (brand name: Celebrex) and rofecoxib (brand name: Vioxx).
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Deep vein thrombosis: A blood clot ( thrombus ) in a deep vein in the thigh or leg. The clot can break off as an embolus and make its way to the lung, where it can cause respiratory distress and respiratory failure .
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Diarrhea : A familiar phenomenon with unusually frequent or unusually liquid bowel movements, excessive watery evacuations of fecal material. The opposite of constipation . The word "diarrhea" with its odd spelling is a near steal from the Greek "diarrhoia" meaning "a flowing through." Plato and Aristotle may have had diarrhoia while today we have diarrhea. There are myriad infectious and noninfectious causes of diarrhea.
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Double-blind: Term used to described a study in which both the investigator or the participant are blind to (unaware of) the nature of the treatment the participant is receiving. Double-blind trials are thought to produce objective results, since the expectations of the researcher and the participant about the experimental treatment such as a drug do not affect the outcome. Also called double-masked. See also: Double-blinded study .
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Embolism: The obstruction of a blood vessel by a foreign substance or a blood clot blocking the vessel. Something travels through the bloodstream, lodges in a vessel and plugs it.
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Enzyme: A protein (or protein-based molecule) that speeds up a chemical reaction in a living organism. An enzyme acts as catalyst for specific chemical reactions , converting a specific set of reactants (called substrates) into specific products. Without enzymes, life as we know it would not exist.
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FDA: The Food and Drug Administration, an agency within the U.S. Public Health Service, which is a part of the Department of Health and Human Services.
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Fiber : The parts of plants that cannot be digested, namely complex carbohydrates. Also known as bulk or roughage.
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Focal: Pertaining to a focus which in medicine may refer to:
1. The point at which rays converge as, for example, in the focal point.
2. A localized area of disease. A focal cancer is limited to one specific area.
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Food and Drug Administration: The FDA, an agency within the U.S. Public Health Service, which is a part of the Department of Health and Human Services.
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Gout: Condition characterized by abnormally elevated levels of uric acid in the blood, recurring attacks of joint inflammation ( arthritis ), deposits of hard lumps of uric acid in and around the joints, and decreased kidney function and kidney stones . Uric acid is a breakdown product of purines, that are part of many foods we eat. The tendency to develop gout and elevated blood uric acid level (hyperuricemia) is often inherited and can be promoted by obesity , weight gain, alcohol intake, high blood pressure , abnormal kidney function, and drugs. The most reliable diagnostic test for gout is the identification of crystals in joints, body fluids and tissues.
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Heart: The muscle that pumps blood received from veins into arteries throughout the body. It is positioned in the chest behind the sternum (breastbone; in front of the trachea, esophagus, and aorta; and above the diaphragm muscle that separates the chest and abdominal cavities. The normal heart is about the size of a closed fist, and weighs about 10.5 ounces. It is cone-shaped, with the point of the cone pointing down to the left. Two-thirds of the heart lies in the left side of the chest with the balance in the right chest.
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Heart attack: The death of heart muscle due to the loss of blood supply. The loss of blood supply is usually caused by a complete blockage of a coronary artery, one of the arteries that supplies blood to the heart muscle. Death of the heart muscle, in turn, causes chest pain and electrical instability of the heart muscle tissue.
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Ibuprofen: A non-steroidal anti-inflammatory drug (NSAID) commonly used to treat pain, swelling, and fever . Common brand names for Ibuprofen include Advil, Motrin, and Nuprin.
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Infarction: The formation of an infarct, an area of tissue death due to a local lack of oxygen.
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Injury: Harm or hurt. The term "injury" may be applied in medicine to damage inflicted upon oneself as in a hamstring injury or by an external agent on as in a cold injury . The injury may be accidental or deliberate, as with a needlestick injury . The term "injury" may be synonymous (depending on the context) with a wound or with trauma .
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Intern: In medicine, a doctor who has completed medical school and is engaged in a year of additional training at a hospital before residency. An intern may, for example, be in pediatrics or medicine (internal medicine). The internship year is often quite rigorous.
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Itching: An uncomfortable sensation in the skin that feels as if something is crawling on the skin or in the skin, and makes the person want to scratch the affected area.
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JAMA: The Journal of the American Medical Association. JAMA began publication in 1883. It now bills itself as "the world's best-read medical journal". However one defines "best-read", JAMA clearly ranks as one of the two leading general medical journals published in the United States. (The other is the New England Journal of Medicine.)
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Kidney: One of a pair of organs located in the right and left side of the abdomen which clear "poisons" from the blood, regulate acid concentration and maintain water balance in the body by excreting urine. The kidneys are part of the urinary tract. The urine then passes through connecting tubes called "ureters" into the bladder. The bladder stores the urine until it is released during urination.

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Kidney stone : A stone in the kidney (or lower down in the urinary tract).
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Knee: The knee is a joint which has three parts. The thigh bone (the femur) meets the large shin bone (the tibia) to form the main knee joint. This joint has an inner (medial) and an outer (lateral) compartment. The kneecap (the patella) joins the femur to form a third joint, called the patellofemoral joint. The patella protects the front of the knee joint.
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Leg: In popular usage, the leg extends from the top of the thigh down to the foot. However, in medical terminology, the leg refers to the portion of the lower extremity from the knee to the ankle.
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Liver: An organ in the upper abdomen that aids in digestion and removes waste products and worn-out cells from the blood. The liver is the largest solid organ in the body. The liver weighs about three and a half pounds (1.6 kilograms). It measures about 8 inches (20 cm) horizontally (across) and 6.5 inches (17 cm) vertically (down) and is 4.5 inches (12 cm) thick.

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Lungs: The lungs are a pair of breathing organs located with the chest which remove carbon dioxide from and bring oxygen to the blood. There is a right and left lung.
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Methadone: A synthetic opiate . The most common medical use for methadone is as a legal substitute for heroin in treatment programs for drug addiction. It is usually administered to participating addicts daily in the form of a green, tasteless liquid at a drug treatment clinic. See also: Methadone treatment program .
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Morphine: A powerful narcotic agent with strong analgesic (painkilling) action and other significant effects on the central nervous system . It is dangerously addicting. Morphine is a naturally occurring member of a large chemical class of compounds called alkaloids.
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Mouth: 1. The upper opening of the digestive tract, beginning with the lips and containing the teeth, gums, and tongue. Foodstuffs are broken down mechanically in the mouth by chewing and saliva is added as a lubricant. Saliva contains amylase, an enzyme that digests starch. 2. Any opening or aperture in the body. The mouth in both senses of the word is also called the os, the Latin word for an opening, or mouth. The o in os is pronounced as in hope. The genitive form of os is oris from which comes the word oral.
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Myocardial infarction: A heart attack . Abbreviated MI.
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Naproxen : A non-steroidal anti-inflammatory drug (NSAID) used for the management of mild to moderate pain, fever, and inflammation . Naproxen blocks the enzyme cyclooxygenase that makes prostaglandins, resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. Brand names for naproxen include Anaprox, Naprelan, Naprosyn, and Aleve.
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Narcotic: 1. A drug that causes insensibility or stupor. A narcotic induces narcosis, from the Greek "narke" for "numbness or torpor."
2. A drug such as marijuana which is subject to regulatory restrictions comparable to those for addictive narcotics.
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Nausea: Nausea, is the urge to vomit. It can be brought by many causes including, systemic illnesses, such as influenza , medications, pain, and inner ear disease. When nausea and/or vomiting are persistent, or when they are accompanied by other severe symptoms such as abdominal pain , jaundice , fever, or bleeding, a physician should be consulted.
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NIDA: Stands for the National Institute on Drug Abuse, one of the National Institutes of Health in the U.S., whose mission is to "lead the nation in bringing the power of science to bear on drug abuse and addiction through support and conduct of research across a broad range of disciplines and rapid and effective dissemination of results of that research to improve drug abuse and addiction prevention, treatment, and policy."
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Nonsteroidal anti-inflammatory drug : A type of drug commonly prescribed for the treatment of inflammation of arthritis and other body tissues, such as in tendinitis and bursitis . Examples of NSAIDs include aspirin, indomethacin (Indocin), ibuprofen (Motrin), naproxen (Naprosyn), piroxicam (Feldene), and nabumetone (Relafen). Abbreviated NSAID.
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NSAID: Nonsteroidal anti-inflammatory drug. NSAIDs are commonly prescribed for the inflammation of arthritis and other body tissues, such as in tendinitis and bursitis . Examples of NSAIDs include aspirin, indomethacin (Indocin), ibuprofen (Motrin), naproxen (Naprosyn), piroxicam (Feldene), and nabumetone (Relafen).
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Onset: In medicine, the first appearance of the signs or symptoms of an illness as, for example, the onset of rheumatoid arthritis . There is always an onset to a disease but never to the return to good health. The default setting is good health.
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Opiate: A medication or illegal drug that is either derived from the opium poppy, or that mimics the effect of an opiate (a synthetic opiate). Opiate drugs are narcotic sedatives that depress activity of the central nervous system, reduce pain, and induce sleep . Side effects may include oversedation, nausea, and constipation . Long- term use of opiates can produce addiction, and overuse can cause overdose and potentially death.
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Opioid: 1. A synthetic narcotic that resembles the naturally occurring opiates. 2. Any substance that binds to or otherwise affects the opiate receptors on the surface of the cell.
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Osteoarthritis: A type of arthritis caused by inflammation, breakdown, and eventual loss of cartilage in the joints. Also known as degenerative arthritis .
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Oxycodone: Oxycodone is the active ingredient in OxyContin. Oxycodone is an opioid, a close relative of morphine, heroin, codeine , fentanyl, and methadone.
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OxyContin : A prescription painkiller that has become a popular and dangerous recreational drug. Also called "Oxy" in the street.
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Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia . Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors.
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Pain management : The process of providing medical care that alleviates or reduces pain. Pain management is an extremely important part of health care, as patients forced to remain in severe pain often become agitated and/or depressed and have poorer treatment outcomes. Mild to moderate pain can usually be treated with analgesic medications, such as aspirin or ibuprofen . For chronic or severe pain, opiates and other narcotics are often used, sometimes in concert with analgesics; with steroids or non-steroidal anti-inflammatory drugs when the pain is related to inflammation; or with anti-depressants, which can potentiate some pain medications without raising the actual dose of the drug, and which affect the brain's perception of pain. Narcotics carry with them a potential for side effects and addiction, so patients and caregivers must weigh the level of pain against these dangers in the pain management process. The risk of addiction is not normally a concern in the care of terminal patients.
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Pharmacy: A location where prescription drugs are sold. A pharmacy is, by law, constantly supervised by a licensed pharmacist.
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Placebo: A "sugar pill" or any dummy medication or treatment.
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Prescription: A physician's order for the preparation and administration of a drug or device for a patient. A prescription has several parts. They include the superscription or heading with the symbol "R" or "Rx", which stands for the word recipe (meaning, in Latin, to take); the inscription, which contains the names and quantities of the ingredients; the subscription or directions for compounding the drug; and the signature which is often preceded by the sign "s" standing for signa (Latin for mark), giving the directions to be marked on the container.
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Pulmonary: Having to do with the lungs. (The word comes from the Latin pulmo for lung).
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Randomized: The use of chance alone to assign the participants in an experiment or trial to different groups in order to fairly compare the outcomes with different treatments. Randomization is an important feature of experimental design.
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Rash : Breaking out (eruption) of the skin. Medically, a rash is referred to as an exanthem.
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Sensation: In medicine and physiology , sensation refers to the registration of an incoming ( afferent ) nerve impulse in that part of the brain called the sensorium , which is capable of such perception. Therefore, the awareness of a stimulus as a result of its perception by sensory receptors. (Sensory is here synonymous with sensation.)
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Shortness of breath: Difficulty in breathing . Medically referred to as dyspnea . Shortness of breath can be caused by respiratory (breathing passages and lungs ) or circulatory ( heart and blood vessels) conditions. See also dyspnea.
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Sinus: 1. An air-filled cavity in a dense portion of a skull bone. The sinuses decrease the weight of the skull. The sinuses are formed in four right-left pairs. The frontal sinuses are positioned behind the forehead, while the maxillary sinuses are behind the cheeks. The sphenoid and ethmoid sinuses are deeper in the skull behind the eyes and maxillary sinuses. The sinuses are lined by mucous-secreting cells. Air enters the sinuses through small opening in bone called ostia. If an ostium is blocked, air cannot pass into the sinus and likewise mucous cannot drain out. See also: Sinusitis .
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Sodium: The major positive ion (cation) in fluid outside of cells. The chemical notation for sodium is Na⁺. When combined with chloride, the resulting substance is table salt.
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Spinal cord: The major column of nerve tissue that is connected to the brain and lies within the vertebral canal and from which the spinal nerves emerge. Thirty-one pairs of spinal nerves originate in the spinal cord: 8 cervical , 12 thoracic , 5 lumbar, 5 sacral, and 1 coccygeal. The spinal cord and the brain constitute the central nervous system ( CNS ). The spinal cord consists of nerve fibers that transmit impulses to and from the brain. Like the brain, the spinal cord is covered by three connective-tissue envelopes called the meninges . The space between the outer and middle envelopes is filled with cerebrospinal fluid ( CSF ), a clear colorless fluid that cushions the spinal cord against jarring shock. Also known simply as the cord.
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Sprain: An injury to a ligament that results from overuse or trauma . Sprains occurs when there is a stretch or tear in one or more ligaments, slightly elastic bands of tissue that keep the bones in place while permitting movement at a joint. The treatment of a sprain involves applying ice packs, resting and elevating the involved joint, and using anti-inflammatory medications. Depending on the severity and location of the sprain, support bracing can help. Local cortisone injections are sometimes given for persistent inflammation . Activity may be resumed gradually. Ice application after activity can reduce or prevent recurrent inflammation. Occasionally, supportive bracing can prevent reinjury. In severe sprains, orthopedic surgical repair may be performed.
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Stomach: 1. The sac-shaped digestive organ that is located in the upper abdomen, under the ribs. The upper part of the stomach connects to the esophagus, and the lower part leads into the small intestine.
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Stool: The solid matter discharged in a bowel movement.
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Stroke: The sudden death of some brain cells due to a lack of oxygen when the blood flow to the brain is impaired by blockage or rupture of an artery to the brain. A stroke is also called a cerebrovascular accident or, for short, a CVA.
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Substance: 1. Material with particular features, as a pressor substance .
2. The material that makes up an organ or structure. Also known in medicine as the substantia.
3. A psychoactive drug as, for example, in substance abuse .
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Substance abuse: The excessive use of a substance, especially alcohol or a drug. (There is no universally accepted definition of substance abuse.)
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Surgery: The word "surgery" has multiple meanings. It is the branch of medicine concerned with diseases and conditions which require or are amenable to operative procedures. Surgery is the work done by a surgeon. By analogy, the work of an editor wielding his pen as a scalpel is s form of surgery. A surgery in England (and some other countries) is a physician's or dentist's office.
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Therapy: The treatment of disease .
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Thrombosis: The formation or presence of a blood clot in a blood vessel . The vessel may be any vein or artery as, for example, in a deep vein thrombosis or a coronary (artery) thrombosis. The clot itself is termed a thrombus . If the clot breaks loose and travels through the bloodstream, it is a thromboembolism. Thrombosis, thrombus, and the prefix thrombo- all come from the Greek thrombos meaning a lump or clump, or a curd or clot of milk. See entries also to: Cavernous sinus thrombosis ; Renal vein thrombosis . And see: Deep Vein Thrombosis and Pulmonary Embolism .
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Toxicity: The degree to which a substance can harm humans or animals.
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Tremor: Any abnormal repetitive shaking movement of the body. Tremors have many causes and can be inherited, be related to illnesses such as thyroid disease , or caused by fever , hypothermia, drugs or fear.
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Tylenol: See: Acetaminophen .
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Ulcer: An area of tissue erosion, for example, of the skin or lining of the gastrointestinal (GI) tract. Due to the erosion, an ulcer is concave. It is always depressed below the level of the surrounding tissue.
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NOTE: April 7, 2005, Pfizer agreed to suspend sales and marketing of Bextra in the U.S., pending further discussions with the with the FDA. For more information, please read the FDA press release.
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Vein: A blood vessel that carries blood low in oxygen content from the body back to the heart. The deoxygenated form of hemoglobin (deoxyhemoglobin) in venous blood makes it appear dark. Veins are part of the afferent wing of the circulatory system which returns blood to the heart.
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Voluntary: Done in accordance with the conscious will of the individual. The opposite of involuntary.
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Withdrawal symptoms: Abnormal physical or psychological features that follow the abrupt discontinuation of a drug that has the capability of producing physical dependence. Common withdrawal symptoms include sweating, tremor , vomiting, anxiety , insomnia , and muscle pain .
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