Pap Smear Glossary of Terms

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Abnormal: Outside the expected norm, or uncharacteristic of a particular patient.

Adenocarcinoma: A cancer that develops in the lining or inner surface of an organ and usually has glandular (secretory) properties. More than 95 percent of prostate cancers are adenocarcinomas.

Anesthesia: Loss of feeling or awareness, as when an anesthetic is administered before surgery.

Atypical: Unusual, or not fitting a single diagnostic
category.

Biopsy: The removal of a sample of tissue for examination under a microscope to check for cancer cells or other abnormalities.

Birth control: Birth control is the use of any practices, methods, or devices to prevent pregnancy from occurring in a sexually active woman. Also referred to as family planning, pregnancy prevention, fertility control, or contraception; birth control methods are designed either to prevent fertilization of an egg or implantation of a fertilized egg in the uterus.
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Cancer: An abnormal growth of cells which tend to proliferate in an uncontrolled way and, in some cases, to metastasize (spread).
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Cancer of the cervix: See: Cervical cancer.

Cell: The basic structural and functional unit of any living thing. Each cell is a small container of chemicals and water wrapped in a membrane. There are 100 trillion cells in a human, and each contains all of the genetic information necessary to manufacture a human being. This information is encoded within the cell nucleus in 6 billion subunits of DNA called base pairs. These base pairs are packaged in 23 pairs of chromosomes, with 1 chromosome in each pair coming from each parent. Each of the 46 human chromosomes contains the DNA for thousands of individual genes.

Cervical: Having to do with any kind of neck, including the neck on which the head is perched and the neck of the uterus.

Cervical cancer: Cancer of the entrance to the womb (uterus). The cervix is the lower, narrow part of the uterus (womb). The uterus, a hollow, pear-shaped organ, is located in a woman's lower abdomen, between the bladder and the rectum. The cervix forms a canal that opens into the vagina, which leads to the outside of the body.

Cervix: The cervix is the lower, narrow part of the uterus (womb). The uterus, a hollow, pear-shaped organ, is located in a woman's lower abdomen, between the bladder and the rectum. The cervix forms a canal that opens into the vagina, which leads to the outside of the body.

Colposcope: A lighted magnifying instrument used by a gynecologist to examine the tissues of the vagina and the cervix. The procedure is called colposcopy.

Colposcopy: A procedure in which a lighted magnifying instrument called a colposcope (or vaginoscope) is used to examine the vagina and cervix.

Cure: 1. To heal, to make well, to restore to good health. Cures are easy to claim and, all too often, difficult to confirm.
2. A time without recurrence of a disease so that the risk of recurrence is small, as in the 5-year cure rate for malignant melanoma.
3. Particularly in the past, a course of treatment. For example, take a cure at a spa.
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Diagnosis: 1 The nature of a disease; the identification of an illness. 2 A conclusion or decision reached by diagnosis. The diagnosis is rabies. 3 The identification of any problem. The diagnosis was a plugged IV.
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Discharge: 1.The flow of fluid from part of the body, such as from the nose or vagina.
2. The passing of an action potential, such as through a nerve or muscle fiber.
3. The release of a patient from a course of care. The doctor may then dictate a discharge summary.

Fixative: A medium such as a solution or spray that preserves specimens of tissues or cells. Most biopsies and specimens removed at surgery are fixed in a solution such as formalin (dilute formaldehyde) before further processing takes place. Other common ingredients used in fixatives are alcohol, mercuric chloride, potassium dichromate and sodium sulfate.
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Genital: Pertaining to the external and/or internal organs of reproduction.

Herpes: A family of viruses. Herpes also refers to infection with one of the human herpesviruses, especially herpes simplex types 1 and 2.
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HIV: Acronym for the Human Immunodeficiency Virus, the cause of AIDS (acquired immunodeficiency syndrome). HIV has also been called the human lymphotropic virus type III, the lymphadenopathy-associated virus and the lymphadenopathy virus. No matter what name is applied, it is a retrovirus. (A retrovirus has an RNA genome and a reverse transcriptase enzyme. Using the reverse transcriptase, the virus uses its RNA as a template for making complementary DNA which can integrate into the DNA of the host organism).
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HPV: Human papillomavirus.

Human immunodeficiency virus: HIV, the cause of AIDS. HIV has also been called the human lymphotropic virus type III, the lymphadenopathy-associated virus and the lymphadenopathy virus. No matter what name is applied, it is a retrovirus. (A retrovirus has an RNA genome and a reverse transcriptase enzyme. Using the reverse transcriptase, the virus uses its RNA as a template for making complementary DNA which can integrate into the DNA of the host organism). Although the American research Robert Gallo at the National Institutes of Health believed he was the first to find HIV, it is now generally accepted that the French physician Luc Montagnier (1932-) and his team at the Pasteur Institute discovered HIV in 1983- 84.

Human papillomavirus: One of the family of more than 100 viruses that are responsible for causing warts. Abbreviated HPV. The majority of HPVs produce warts on the hands, fingers, or face. Most of these warts are innocuous, causing nothing more than cosmetic concerns. Several types of HPV are confined primarily to the moist skin of the genitals, producing genital warts, and have been identified as a cause of cancer of the cervix and other cancers of the ano-genital region. The HPVs that cause wartlike growths on the genitals are sexually transmitted. A vaccine is available that protects against infection by the most common types of HPVs that are associated with cancer and genital warts.

Immune: Protected against infection, usually by the presence of antibodies.

Immune system: A complex system that is responsible for distinguishing a person from everything foreign to him or her and for protecting his or her body against infections and foreign substances.

Immunodeficiency: The inability to form a normal immune response. Immunodeficiency can be due to a genetic disease or it can be acquired, as in AIDS.

In situ: In the normal location. An in situ tumor is one that is confined to its site of origin and has not invaded neighboring tissue or gone elsewhere in the body. For example, squamous cell carcinoma in situ is an early stage of skin cancer.

Incidence: The frequency with which something, such as a disease or trait, appears in a particular population or area.

Indicate: In medicine, to make a treatment or procedure advisable because of a particular condition or circumstance. For example, certain medications are indicated for the treatment of hypertension during pregnancy while others are contraindicated.

Infection: The invasion and multiplication of microorganisms such as bacteria, viruses, and parasites that are not normally present within the body. An infection may cause no symptoms and be subclinical, or it may cause symptoms and be clinically apparent. An infection may remain localized, or it may spread through the blood or lymphatic vessels to become systemic (bodywide). Microorganisms that live naturally in the body are not considered infections. For example, bacteria that normally live within the mouth and intestine are not infections.

Intraepithelial: Within the layer of cells that forms the surface or lining of an organ. For example, a blister forms fluid in the intraepithelial layer of the skin.

Lesion: An area of abnormal tissue change. Lesions vary in severity from harmless to serious.

Menopause: The time in a woman's life when menstrual periods permanently stop; it is also called the "change of life." Menopause is the opposite of the menarche.
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Microscope: An optical instrument that augments the power of the eye to see small objects. The name microscope was coined by Johannes Faber (1574-1629) who in 1628 borrowed from the Greek to combined micro-, small with skopein, to view. Although the first microscopes were simple microscopes, most (if not all) optical microscopes today are compound microscopes.

Microscopic: So small it cannot be seen without the aid of microscope. As opposed to macroscopic (large enough to be seen with naked eye). A tiny tumor is microscopic while a big tumor is macroscopic.

Mucus: A thick fluid that is produced by the lining of some organs of the body.

Neoplasia: Abnormal new growth of cells.

Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia. Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors.
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Pap Smear: A screening test for cervical cancer based on the examination under the microscope of cells collected from the cervix, smeared on a slide and specially stained to reveal premalignant (before cancer) and malignant (cancer) changes as well as changes due to noncancerous conditions such as inflammation from infections.
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Pap test: A screening test for cervical cancer that involves the microscopic examination of cells collected from the cervix, smeared on a slide, and specially stained. A Pap test can reveal premalignant and malignant changes in the cells, as well as changes that are due to noncancerous conditions, such as inflammation. Named after the physician George Papanicolaou, who developed the test. Also known as Pap smear.

Pelvic: Having to do with the pelvis, the lower part of the abdomen, located between the hip bones.

Pelvic exam: An examination of the organs of the female reproductive system.
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Precancerous: Pertaining to something that is not yet overtly cancerous, but appears to be on its way to becoming a cancer. Synonymous with premalignant.

Pregnancy: The state of carrying a developing embryo or fetus within the female body. This condition can be indicated by positive results on an over-the-counter urine test, and confirmed through a blood test, ultrasound, detection of fetal heartbeat, or an X-ray. Pregnancy lasts for about nine months, measured from the date of the woman's last menstrual period (LMP). It is conventionally divided into three trimesters, each roughly three months long.
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Speculum: An instrument that is used to widen the opening of the vagina so that the cervix is more easily visible.

Squamous cells: Flat cells that look like fish scales. The word "squamous" came from the Latin squama meaning "the scale of a fish or serpent."
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Squamous intraepithelial lesion: A general term for the abnormal growth of squamous cells on the surface of the cervix. The changes in the cells are described as low grade or high grade, depending on how much of the cervix is affected and how abnormal the cells are. Also called SIL.

Stomach: The digestive organ that is located in the upper abdomen, under the ribs. The upper part of the stomach connects to the esophagus, and the lower part leads into the small intestine. When food enters the stomach, muscles in the stomach wall create a rippling motion (peristalsis) that mixes and mashes the food. At the same time, juices made by glands in the lining of the stomach help digest the food. After about 3 hours, the food becomes a liquid and moves into the small intestine, where digestion continues.

Trichomonas: A single-celled protozoan parasite best known in medicine because one species causes vaginitis (vaginal inflammation). Infection with trichomonas (trichomoniasis) is the most common curable sexually transmitted disease (STD) in young sexually active women.) in young sexually active women. The species of trichomonas responsible for STD is Trichomonas vaginalis. The vagina is the most common site of infection in women, and the urethra (urine canal) is the most common site of infection in men. The parasite is sexually transmitted through penis-to-vagina intercourse or vulva-to-vulva (the genital area outside the vagina) contact with an infected partner. Women can acquire the disease from infected men or women, but men usually contract it only from infected women.
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Uterus: A hollow, pear-shaped organ that is located in a woman's lower abdomen, between the bladder and the rectum. The narrow lower portion of the uterus is the cervix (the neck of the uterus). The broader upper part is the corpus, which is made up of three layers of tissue. In women of childbearing age, the inner layer (endometrium) of the uterus goes through a series of monthly changes known as the menstrual cycle. Each month, endometrial tissue grows and thickens in preparation to receive a fertilized egg. Menstruation occurs when this tissue is not used, disintegrates, and passes out through the vagina. The middle layer (myometrium) of the uterus is muscular tissue that expands during pregnancy to hold the growing fetus and contracts during labor to deliver the child. The outer layer (parametrium) also expands during pregnancy and contracts thereafter.

Vagina: The muscular canal that extends from the cervix to the outside of the body. It is usually 6 to 7 inches in length, and its walls are lined with mucous membrane. It includes two vaultlike structures: the anterior (front) vaginal fornix and the posterior (rear) vaginal fornix. The cervix protrudes slightly into the vagina, and through a tiny hole in the cervix (the os), sperm make their way toward the internal reproductive organs. The vagina also includes numerous tiny glands that make vaginal secretions.

Vaginal discharge: Vaginal discharge is a fluid produced by glands in the vaginal wall and cervix that drains from the opening of the vagina. The amount and appearance of normal vaginal discharge varies throughout the menstrual cycle. An increase in the amount of vaginal discharge, an abnormal odor or consistency of the fluid, or pain that accompanies vaginal discharge can all be signs of infection or other disorders. Such disorders include (this is not an all inclusive list) bacterial vaginosis, yeast vaginitis, and vaginitis.

Viral: Of or pertaining to a virus. For example, if a person has a viral rash, the rash was caused by a virus.

Virus: A microorganism that is smaller than a bacterium that cannot grow or reproduce apart from a living cell. A virus invades living cells and uses their chemical machinery to keep itself alive and to replicate itself. It may reproduce with fidelity or with errors (mutations); this ability to mutate is responsible for the ability of some viruses to change slightly in each infected person, making treatment difficult. Viruses cause many common human infections and are also responsible for a number of rare diseases. Examples of viral illnesses range from the common cold, which can be caused by one of the rhinoviruses, to AIDS, which is caused by HIV. Viruses may contain either DNA or RNA as their genetic material. Herpes simplex virus and the hepatitis B virus are DNA viruses. RNA viruses have an enzyme called reverse transcriptase that permits the usual sequence of DNA-to-RNA to be reversed so that the virus can make a DNA version of itself.
RNA viruses include HIV and hepatitis C virus. Researchers have grouped viruses together into several major families, based on their shape, behavior, and other characteristics. These include the herpes-viruses, adenoviruses, papovaviruses (including
the papillomaviruses), hepadnaviruses, poxviruses, and parvoviruses, among the DNA viruses. On the RNA virus side, major families include the picorna-viruses (including the rhinoviruses), calciviruses, paramyxoviruses, orthomyxoviruses, rhabdoviruses, filoviruses, and retroviruses. There are dozens
of smaller virus families within these major classifications. Many viruses are host specific, capable of infecting and causing disease in humans or specific animals only.