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Papain

How does Papain work?

Papain contains substances called enzymes that help break down proteins.

Are there safety concerns?

Papain is LIKELY SAFE when taken by mouth in amounts commonly found in foods. It is POSSIBLY SAFE when taken by mouth in medicinal amounts and when applied the skin as a solution in appropriate amounts. It can cause irritation of the throat and stomach.

Taking large amounts of papain by mouth is POSSIBLY UNSAFE. In excessive doses, papain can cause severe throat damage. Also, applying raw papain to the skin is POSSIBLY UNSAFE. Skin contact with raw papain can cause irritation and blisters.

There have also been reports of severe allergic reactions.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Taking papain by mouth during pregnancy is POSSIBLY UNSAFE. There is a concern that it might cause birth defects or miscarriage. Not enough is known about the safety of using papain during breast-feeding. Do not use it if you are pregnant or breast-feeding.

Allergy to fig or kiwi fruit: One case report suggests that people who are allergic to fig and kiwi might also be allergic to papain.

Bleeding disorders: There is a concern that papain might increase the risk of bleeding in people with a clotting disorder.

Surgery: Papain might increase the risk of bleeding during surgery. Stop taking papain 2 weeks before surgery.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.



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