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Periodic Limb Movement Disorder (cont.)

Periodic Limb Movement Disorder Treatment

Treatment does not cure the disorder but usually relieves symptoms.

Medical Treatment

Patient Comments

Treatment involves medication that either reduces the movements or helps the person sleep through the movements.

Medications

Therapy does not cure PLMD but relieves symptoms. Note that many of the medications used to treat PLMD are the same as those used to treat restless legs syndrome.

  • Benzodiazepines: These drugs suppress muscle contractions. They are also sedatives and help you sleep through the movements. Clonazepam (Klonopin), in particular, has been shown to reduce the total number of periodic limb movements per hour. It is probably the most widely used drug to treat PLMD.
  • Dopaminergic agents: These drugs increased the levels of an important neurotransmitter (brain chemical) called dopamine, which is important in regulating muscle movements. These medications seem to improve the condition in some people but not in others. Widely used examples are a levodopa/carbidopa combination (Sinemet) and pergolide (Permax).
  • Anticonvulsant agents: These medications reduce muscle contractions in some people. The most widely used anticonvulsant in PLMD is gabapentin (Neurontin).
  • GABA agonists: These agents inhibit release of certain neurotransmitters that stimulate muscle contractions. The result is relaxation of contractions. The most widely used of these agents in PLMD is baclofen (Lioresal).
Medically Reviewed by a Doctor on 2/1/2016
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Read What Your Physician is Reading on Medscape

Periodic Limb Movement Disorder »

Periodic limb movement (PLM) disorder is unique in that the movements occur during sleep.

Read More on Medscape Reference »


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