Pernicious Anemia (Vitamin B-12 Deficiency) (cont.)
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Pernicious anemia is typically treated with an intramuscular injection of 1000 micrograms (1 mg) of vitamin B-12 every day for one week, followed by 1 mg every week for four weeks and then 1 mg every month thereafter.
Alternative treatments include high-dose oral vitamin B-12, since a lower-efficiency absorption system for vitamin B-12 exists in the intestine that does not require the presence of IF. The dose required (1 to 2 milligrams/day) is more than 200 times higher than the minimum daily requirement for adults and is significantly higher than that available in most standard multivitamins and B-12 supplements. Nasal spray and sublingual (under the tongue) preparations of vitamin B-12 are also available.
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