DRUG INTERACTIONS: This drug should not be used with the following medications because very serious interactions may occur: aldesleukin, mifepristone. If you are currently using any of these medications, tell your doctor or pharmacist before starting prednisone. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: large doses of aspirin and aspirin-like drugs (salicylates), birth control pills, "blood thinners" (e.g., warfarin), estrogens, nonsteroidal anti-inflammatory drugs (NSAIDs such as indomethacin, ibuprofen), drugs which decrease blood potassium levels (e.g., amphotericin B, "water pills" such as hydrochlorothiazide and furosemide), drugs which affect certain liver enzymes (CYP 3A4 substrates, inhibitors and inducers such as azole antifungals, macrolide antibiotics, rifamycins, certain anti-seizure medications). Do not have any vaccinations, immunizations or skin tests while you are using this drug unless specifically directed by your doctor. Live vaccines may cause serious complications (e.g., infection) if given while you are taking this medication. Consult your doctor for details. Low-dose aspirin, as prescribed by your doctor for heart attack or stroke prevention (usually these dosages are 81-325 mg per day), should be continued. Consult your doctor or pharmacist for more details. Do not start or stop any medicine without doctor or pharmacist approval.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include: severe mental/mood changes, increased thirst or urination, severe muscle weakness.