Premenstrual Dysphoric Disorder (PMDD): Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS). The cause of PMDD is thought to be the complex interactions of hormones produced by the ovaries during a woman's the menstrual cycle. Some common symptoms (not inclusive) of PMDD include fatigue, mood changes, breast tenderness, hot flashes, irritability, and more. Treatment for symptoms of PMDD is generally with medication.