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Procaine

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Are there any interactions with medications?

Digoxin (Lanoxin)
Interaction Rating: Major Do not take this combination.

Digoxin (Lanoxin) helps the heart beat more strongly. Digoxin (Lanoxin) can also control how fast the heart beats. Getting a procaine injection can slow the heartbeat. Taking digoxin with procaine might cause your heartbeat to be too slow.

Muscle relaxants
Interaction Rating: Major Do not take this combination.

Procaine is given as a shot to numb pain. Taking procaine with some muscle relaxants can cause the numbing to last too long. Before getting a procaine injection tell your doctor if you are taking any muscle relaxants.

Some of these muscle relaxants include atracurium (Tracrium), pancuronium (Pavulon), succinylcholine (Anectine), and others.

Succinylcholine
Interaction Rating: Major Do not take this combination.

Procaine is injected and used to numb pain. Taking procaine with succinylcholine can cause the numbing to last too long.

Aminosalicylic acid
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down procaine to get rid of it. Procaine is broken down to a chemical called aminobenzoic acid. Aminobenzoic acid might decrease the effectiveness of aminosalicylic acid. Taking procaine along with aminosalicylic acid might decrease the effectiveness of aminosalicylic acid.

Antibiotics (Sulfonamide antibiotics)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body changes procaine to para-aminobenzoic acid (PABA). PABA can decrease the effectiveness of certain antibiotics called sulfonamides.

Some of these antibiotics include sulfamethoxazole (Gantanol), sulfasalazine (Azulfidine), sulfisoxazole (Gantrisin), and trimethoprim/sulfamethoxazole (Bactrim, Septra).