Progesterone

Are there any interactions with medications?

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Estrogens
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Progesterone and estrogen are both hormones. They are often taken together. Progesterone can decrease some of the side effects of estrogen. But progesterone might also decrease the beneficial effects of estrogen. Taking progesterone along with estrogen might cause breast tenderness.

Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.

Dosing considerations for Progesterone.

The following doses have been studied in scientific research:

BY MOUTH:

• For hormone replacement therapy: 200 mg micronized progesterone (Prometrium) per day is typically taken for 12 days of a 25-day cycle with 0.625 mg conjugated estrogens.

APPLIED TO THE SKIN:

• For hot flashes and other symptoms of menopause: 20 mg progesterone cream (equivalent to 1/4 teaspoon Progest cream) is typically applied daily to rotating places on the body including upper arms, thighs, or breasts.

INSIDE THE VAGINA:

• For breast pain associated with noncancerous breast disease: a typical dose of 4 grams of vaginal cream containing 2.5% natural progesterone is placed inside the vagina from the 19th to the 25th day of a 28-day cycle.
• For restoring menstrual periods in women who have not reached menopause: one applicator (90 mg) of progesterone gel (Crinone 4% or 8%) is typically placed inside the vagina every other day for 6 days per month.
• For hormone replacement therapy, one applicator (90 mg) of progesterone gel (Crinone 4% or 8%) is typically placed inside the vagina on days 17, 19, 21, 23, 25, and 27 of a 28-day cycle with 0.625 mg conjugated equine estrogens.
• For reducing vaginal bleeding and reversing the thickening of the lining of the uterus in premenopausal women with noncancerous endometrial hyperplasia: a dose of 100 mg progesterone cream placed inside the vagina daily from day 10 to day 25 of a 28-day cycle has been used.