July 6, 2009

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Pseudoephedrine (Sudafed)

Tips to Navigate Through the OTC and Prescription Drug Jungle

Medical Author: Benjamin C. Wedro, MD, FAAEM
Medical Editor: Melissa Conrad Stöppler, MD

Pharmacists can assist with OTC and prescription drug information like side effects and potential drug interactionsChoice is often a wonderful thing for the consumer. But sometimes too many options can make shopping tough, and it may even be deadly as far as medications are concerned.

Walking into a supermarket or pharmacy, you are confronted with shelf upon shelf of medications advertised to cure everything from cold symptoms to warts. There are the nationally advertised brands, the stores' own label, and generic products, all packaged to confuse even the most savvy shopper. Advertisements in magazines and on television tout the latest and greatest advances in products to help treat you and your family. Need advice? Join the crowd.

Headlines are made when medication errors happen in hospitals. Dennis Quaid's twins were accidentally given an overdose of heparin, a blood-thinning drug. The Institute of Medicine reports that thousands of people die each year in hospitals because medications were given inappropriately:

  • the wrong drug was given to the patient,

  • the wrong dose was administered to the patient, or

  • drug interactions occurred.

Imagine that these errors happened in a place where professionals - nurses, doctors and pharmacists - do this for a living. What chance does the average person have, wandering through the nonprescription aisles of the local store?

The salvation lies with the professional behind the counter.

Pseudoephedrine (Sudafed) Information

Sudafed is one of the more popular the brand names. Pseudoephedrine is the generic name. Pseudoephedrine is a sympathomimetic (adrenergic) agent used to treat hay fever and allergies. For information on sympathomimetic (adrenergic) agents and how they work, see Understanding Allergy and Hay Fever Medications.

Why is Pseudoephedrine Used?

Pseudoephedrine is a decongestant used for temporary relief of nasal congestion caused by hay fever, allergies, the common cold, sinus infections, or other upper respiratory diseases. Decongestants act on the adrenergic receptors in the nasal passages and constrict (narrow) the blood vessels. This action results in relief of the stuffy feeling related to nasal congestion. Decongestant use promotes nasal and sinus drainage. It is available in prompt-acting and long-acting capsules and tablets, chewable tablets, syrup, and oral drops. It is often combined with antihistamines, and these preparations are often, but not always, labeled with "D" (for example, Allegra-D, Claritin-D, and Zyrtec-D).

Who Should Not Take Pseudoephedrine?

  • Individuals who are allergic to pseudoephedrine or any of its ingredients


  • Individuals who are taking, or have taken within the last two weeks, monoamine oxidase inhibitors (MAOIs), such as phenelzine (Nardil) or tranylcypromine (Parnate)


  • Children younger than 12 years should not take the sustained-release (long-acting) formulations.



Next: Special Warnings With Pseudoephedrine »

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