Psoriasis Glossary of Medical Terms

Abdomen: The belly , that part of the body that contains all of the structures between the chest and the pelvis . The abdomen is separated anatomically from the chest by the diaphragm , the powerful muscle spanning the body cavity below the lungs .
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Alcoholism: Physical dependence on alcohol to the extent that stopping alcohol use will bring on withdrawal symptoms. In popular and therapeutic parlance, the term may also be used to refer to ingrained drinking habits that cause health or social problems. Treatment requires first ending the physical dependence, then making lifestyle changes that help the individual avoid relapse . In some cases, medication or hospitalization are needed. Alcohol dependence can have many serious effects on the brain , liver , and other organs of the body.
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Aleve: See: Naproxen .
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Allergy : A misguided reaction to foreign substances by the immune system , the body system of defense against foreign invaders, particularly pathogens (the agents of infection ). The allergic reaction is misguided in that these foreign substances are usually harmless. The substances that trigger allergy are called allergen. Examples include pollens , dust mite, molds , danders , and certain foods. People prone to allergies are said to be allergic or atopic .
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Antipsoriatic: Directed against psoriasis . Sunlight is antipsoriatic, as are a number of drugs.
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Anxiety: A feeling of apprehension and fear characterized by physical symptoms such as palpitations , sweating, and feelings of stress . Anxiety disorders are serious medical illnesses that affect approximately 19 million American adults. These disorders fill people's lives with overwhelming anxiety and fear. Unlike the relatively mild, brief anxiety caused by a stressful event such as a business presentation or a first date, anxiety disorders are chronic, relentless, and can grow progressively worse if not treated.
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Arms: An appendage in anatomy and in clinical trials . See: Arm .
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Arthritis: Inflammation of a joint. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis . (see osteoarthritis , rheumatoid arthritis , ankylosing spondylitis , psoriatic arthritis , lupus , gout , pseudogout ).
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Aspirin: A good example of a tradename that entered into the language, Aspirin was once the Bayer trademark for acetylsalicylic acid .
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Bacterial: Of or pertaining to bacteria . For example, a bacterial lung infection .
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Blood pressure: The blood pressure is the pressure of the blood within the arteries. It is produced primarily by the contraction of the heart muscle . It's measurement is recorded by two numbers. The first ( systolic pressure) is measured after the heart contracts and is highest. The second ( diastolic pressure) is measured before the heart contracts and lowest. A blood pressure cuff is used to measure the pressure. Elevation of blood pressure is called " hypertension ".
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Body surface area: BSA. The total suface area of the human body. The BSA is used in many measurements in medicine, including the calculation of drug dosages and the amount of fluids to be administered IV.
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Calcipotriene: A synthetic form of vitamin D3 that can be applied to the skin to treat psoriasis .
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Cancer: An abnormal growth of cells which tend to proliferate in an uncontrolled way and, in some cases, to metastasize (spread).
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Cell: The basic structural and functional unit in people and all living things. Each cell is a small container of chemicals and water wrapped in a membrane .
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Chronic: This important term in medicine comes from the Greek chronos, time and means lasting a long time.
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Chronic disease: A disease that persists for a long time. A chronic disease is one lasting 3 months or more, by the definition of the U.S. National Center for Health Statistics. Chronic diseases generally cannot be prevented by vaccines or cured by medication, nor do they just disappear. Eighty-eight percent of Americans over 65 years of age have at least one chronic health condition (as of 1998). Health damaging behaviors - particularly tobacco use, lack of physical activity, and poor eating habits - are major contributors to the leading chronic diseases.
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Clinical trials: Trials to evaluate the effectiveness and safety of medications or medical devices by monitoring their effects on large groups of people.
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Contrast: Short for "contrast media." Contrast media are X-ray dyes used to provide contrast, for example, between blood vessels and other tissue.
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Cortisone: An adrenocorticoid hormone , a naturally occurring hormone made by and secreted by the adrenal cortex , the outer part (the cortex ) of the adrenal gland .
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Depression : An illness that involves the body, mood, and thoughts, that affects the way a person eats and sleeps, the way one feels about oneself, and the way one thinks about things. A depressive disorder is not the same as a passing blue mood. It is not a sign of personal weakness or a condition that can be wished away. People with a depressive disease cannot merely "pull themselves together" and get better. Without treatment, symptoms can last for weeks, months, or years. Appropriate treatment, however, can help most people with depression.
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Dermatitis: Inflammation of the skin, either due to direct contact with an irritating substance, or to an allergic reaction. Symptoms of dermatitis include redness, itching, and in some cases blistering.
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Dermatologist: A doctor who specializes in the diagnosis and treatment of skin problems.
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Dermatology: 1. The branch of medicine concerned with the diagnosis, treatment, and prevention of diseases of the skin, hair, nails, oral cavity and genitals. 2. Sometimes also, cosmetic care and enhancement.
Dermatology is literally the study of the skin.
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Diagnosis: 1 The nature of a disease ; the identification of an illness. 2 A conclusion or decision reached by diagnosis. The diagnosis is rabies . 3 The identification of any problem. The diagnosis was a plugged IV.
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Dry skin: Abnormally dry skin . Can be caused by a dry climate, winter weather, deficiency of vitamin A , systemic illness, overexposure to sunlight, or medication . The skin loses moisture. It may crack and peel. Or it may become irritated, inflamed, and itch . Bathing frequently, especially with soaps, can contribute to dry skin.
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Elbow: The juncture of the long bones in the middle portion of the arm. The bone of the upper arm (humerus) meets both the ulna (the inner bone of the forearm) and radius (the outer bone of the forearm) to form a hinge joint at the elbow. The radius and ulna also meet one another in the elbow to permit a small amount of rotation of the forearm. The elbow therefore functions to move the arm like a hinge (forward and backward) and in rotation (outward and inward). The biceps muscle is the major muscle that flexes the elbow hinge, and the triceps muscle is the major muscle that extends it. The primary stability of the elbow is provided by the ulnar collateral ligament, located on the medial (inner) side of the elbow. The outer bony prominence of the elbow is the lateral epicondyle, a part of the humerus bone. Tendons attached to this area can be injured, causing inflammation or tendonitis (lateral epicondylitis, or tennis elbow). The inner portion of the elbow is a bony prominence called the medial epicondyle of the humerus. Additional tendons from muscles attach here and can be injured, likewise causing inflammation or tendonitis (medial epicondylitis, or golfer's elbow). See also: Elbow bursitis ; Elbow pain ; Nursemaid's elbow.
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Erythrodermic psoriasis: A particularly inflammatory form of psoriasis that often affects most of the body surface. It is the least common form of psoriasis and most commonly appears on people who have unstable plaque psoriasis, where lesions are not clearly defined. The erythrodermic form of psoriasis is characterized by periodic, widespread, fiery redness of the skin. The erythema (reddening) and exfoliation (shedding) of the skin are often accompanied by severe itching and pain. Swelling may also develop.
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Family history: The family structure and relationships within the family, including information about diseases in family members.
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FDA: The Food and Drug Administration, an agency within the U.S. Public Health Service, which is a part of the Department of Health and Human Services.
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Fever : Although a fever technically is any body temperature above the normal of 98.6 degrees F. (37 degrees C.), in practice a person is usually not considered to have a significant fever until the temperature is above 100.4 degrees F (38 degrees C.).
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Generic: 1. The chemical name of a drug. 2. A term referring to the chemical makeup of a drug rather than to the advertised brand name under which the drug may be sold. 3.A term referring to any drug marketed under its chemical name without advertising.

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Generic drug: The term "generic" has several meanings as regards drugs:

1. The chemical name of a drug.
2. A term referring to the chemical makeup of a drug rather than to the advertised brand name under which the drug is sold.
3. A term referring to any drug marketed under its chemical name without advertising.

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Genes: The basic biological units of heredity . Segments of deoxyribonucleic acid (DNA) needed to contribute to a function.
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Guttate psoriasis: A type of psoriasis characterized by red, scaly patches of inflamed skin on all parts of the body. It is associated with a lung infection in many cases.
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Heart: The muscle that pumps blood received from veins into arteries throughout the body. It is positioned in the chest behind the sternum (breastbone; in front of the trachea, esophagus, and aorta; and above the diaphragm muscle that separates the chest and abdominal cavities. The normal heart is about the size of a closed fist, and weighs about 10.5 ounces. It is cone-shaped, with the point of the cone pointing down to the left. Two-thirds of the heart lies in the left side of the chest with the balance in the right chest.
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Heart failure : Inability of the heart to keep up with the demands on it and, specifically, failure of the heart to pump blood with normal efficiency. When this occurs, the heart is unable to provide adequate blood flow to other organs such as the brain, liver and kidneys. Heart failure may be due to failure of the right or left or both ventricles. The signs and symptoms depend upon which side of the heart is failing. They can include shortness of breath (dyspnea), asthma due to the heart (cardiac asthma), pooling of blood (stasis) in the general body (systemic) circulation or in the liver's (portal) circulation, swelling ( edema ), blueness or duskiness (cyanosis), and enlargement (hypertrophy) of the heart.
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High blood pressure : Also known as hypertension, high blood pressure is, by definition, a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140 with a diastolic pressure above 90.
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HIV: Acronym for the Human Immunodeficiency Virus , the cause of AIDS (acquired immunodeficiency syndrome). HIV has also been called the human lymphotropic virus type III, the lymphadenopathy-associated virus and the lymphadenopathy virus . No matter what name is applied, it is a retrovirus. (A retrovirus has an RNA genome and a reverse transcriptase enzyme. Using the reverse transcriptase , the virus uses its RNA as a template for making complementary DNA which can integrate into the DNA of the host organism).
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Hormone: A chemical substance produced in the body that controls and regulates the activity of certain cells or organs.
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Ibuprofen: A non-steroidal anti-inflammatory drug (NSAID) commonly used to treat pain, swelling, and fever . Common brand names for Ibuprofen include Advil, Motrin, and Nuprin.
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Immune: Protected against infection. The Latin immunis means free, exempt.
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Immune system: A complex system that is responsible for distinguishing us from everything foreign to us, and for protecting us against infections and foreign substances. The immune system works to seek and kill invaders.
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Indication: 1. In medicine, a condition which makes a particular treatment or procedure advisable. CML (chronic myeloid leukemia ) is an indication for the use of Gleevec (imatinib mesylate). 2. A sign or a circumstance which points to or shows the cause, pathology , treatment, or outcome of an attack of disease. The presence of the Philadelphia chromosome in peripheral blood cells is an indication of a relapse in CML.
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Infection: The growth of a parasitic organism within the body. (A parasitic organism is one that lives on or in another organism and draws its nourishment therefrom.) A person with an infection has another organism (a "germ") growing within him, drawing its nourishment from the person.
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Inflammation: A basic way in which the body reacts to infection , irritation or other injury, the key feature being redness, warmth, swelling and pain . Inflammation is now recognized as a type of nonspecific immune response .
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Injury: Harm or hurt. The term "injury" may be applied in medicine to damage inflicted upon oneself as in a hamstring injury or by an external agent on as in a cold injury . The injury may be accidental or deliberate, as with a needlestick injury . The term "injury" may be synonymous (depending on the context) with a wound or with trauma .
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Itching: An uncomfortable sensation in the skin that feels as if something is crawling on the skin or in the skin, and makes the person want to scratch the affected area.
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Joint: A joint is the area where two bones are attached for the purpose of motion of body parts. A joint is usually formed of fibrous connective tissue and cartilage. An articulation or an arthrosis is the same as a joint.
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Juvenile: Between infantile and adult as, for example, in juvenile rheumatoid arthritis (onset before age 16 years) and juvenile diabetes ( type 1 diabetes ).
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Kidney: One of a pair of organs located in the right and left side of the abdomen which clear "poisons" from the blood, regulate acid concentration and maintain water balance in the body by excreting urine. The kidneys are part of the urinary tract. The urine then passes through connecting tubes called "ureters" into the bladder. The bladder stores the urine until it is released during urination.

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Leg: In popular usage, the leg extends from the top of the thigh down to the foot. However, in medical terminology, the leg refers to the portion of the lower extremity from the knee to the ankle.
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Lithium : Lithium carbonate (brand names: Eskalith; Lithobid), a drug used as a mood stabilizer for the treatment of manic/depressive (bipolar) disorder . It prevents or diminishes the intensity of episodes of mania in bipolar patients. Typical symptoms of mania include pressure of speech, motor hyperactivity, reduced need for sleep , flight of ideas, grandiosity, elation, poor judgment, aggressiveness and possibly hostility.
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Liver: An organ in the upper abdomen that aids in digestion and removes waste products and worn-out cells from the blood. The liver is the largest solid organ in the body. The liver weighs about three and a half pounds (1.6 kilograms). It measures about 8 inches (20 cm) horizontally (across) and 6.5 inches (17 cm) vertically (down) and is 4.5 inches (12 cm) thick.

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Lymphoma: Tumor of the lymphoid tissue. Diagnosis is by biopsy. Treatment may be chemotherapy , radiation, surgery, or medication, depending on the age of the patient and type of tumor.
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Malaria : An infectious disease caused by protozoan parasites from the Plasmodium family that can be transmitted by the sting of the Anopheles mosquito or by a contaminated needle or transfusion. Falciparum malaria is the most deadly type.
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Malignancy: A tumor that is malignant, that is cancerous, that can invade and destroy nearby tissue, and that may spread (metastasize) to other parts of the body.
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Menopause : The time in a woman's life when menstrual periods permanently stop; it is also called the "change of life." Menopause is the opposite of the menarche.
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Methotrexate : A drug that acts as an antimetabolite and specifically as a folic acid antagonist that inhibits the synthesis of DNA , RNA , and protein .
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Mouth: 1. The upper opening of the digestive tract, beginning with the lips and containing the teeth, gums, and tongue. Foodstuffs are broken down mechanically in the mouth by chewing and saliva is added as a lubricant. Saliva contains amylase, an enzyme that digests starch. 2. Any opening or aperture in the body. The mouth in both senses of the word is also called the os, the Latin word for an opening, or mouth. The o in os is pronounced as in hope. The genitive form of os is oris from which comes the word oral.
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Nail: In medicine, there are two types of nails. One is just a plain old metal nail used to hold 2 or more pieces of bone together, for example, after a fracture. The other type of nail is the horny plate on the end of the finger or toe. Each nail anatomically has a body, lateral nail folds (on the sides), a lunula (the little moon-shaped feature at the base), and a proximal skin fold (at the base).
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Naproxen : A non-steroidal anti-inflammatory drug (NSAID) used for the management of mild to moderate pain, fever, and inflammation . Naproxen blocks the enzyme cyclooxygenase that makes prostaglandins, resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. Brand names for naproxen include Anaprox, Naprelan, Naprosyn, and Aleve.
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Nausea: Nausea, is the urge to vomit. It can be brought by many causes including, systemic illnesses, such as influenza , medications, pain, and inner ear disease. When nausea and/or vomiting are persistent, or when they are accompanied by other severe symptoms such as abdominal pain , jaundice , fever, or bleeding, a physician should be consulted.
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Ointment: A medication preparation that is applied topically (onto the skin). An ointment has an oil base whereas a cream is water-soluble. (The word ointment comes from the Latin ungere meaning anoint with oil).
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Outpatient: A patient who is not an inpatient (not hospitalized) but instead is cared for elsewhere -- as in a doctor's office, clinic, or day surgery center. The term outpatient dates back at least to 1715. Outpatient care today is also called ambulatory care .
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Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia . Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors.
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Pharmacy: A location where prescription drugs are sold. A pharmacy is, by law, constantly supervised by a licensed pharmacist.
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Phototherapy: Treatment with light. For example, a newborn with jaundice may be "put under the lights."
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Plaque: 1. An semi-hardened accumulation of substances from fluids that bathe an area. Examples include dental plaque and cholesterol plaque.
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Plaque psoriasis: The most common form of psoriasis -- about 80% of people with psoriasis have this type. Plaque psoriasis can appear on any skin surface, although the knees, elbows, scalp, trunk and nails are the most common locations. It is characterized by well-defined patches of red raised skin. The flaky silvery white buildup on top of the plaques is called scale; it is composed of dead skin cells. This scale comes loose and sheds constantly from the plaques. Skin affected with psoriasis is generally very dry, and other possible symptoms include skin pain, itching and cracking. The technical name for plaque psoriasis is psoriasis vulgaris (vulgaris means common).
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Postpartum: In the period just after delivery, as with postpartum depression. Postpartum refers to the mother and postnatal to the baby. From the Latin post, after + partum, birth.
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Pregnancy : The state of carrying a developing embryo or fetus within the female body. This condition can be indicated by positive results on an over-the-counter urine test, and confirmed through a blood test, ultrasound, detection of fetal heartbeat, or an X-ray. Pregnancy lasts for about nine months, measured from the date of the woman's last menstrual period (LMP). It is conventionally divided into three trimesters, each roughly three months long.
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Pregnant: The state of carrying a developing fetus within the body.
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Prescription: A physician's order for the preparation and administration of a drug or device for a patient. A prescription has several parts. They include the superscription or heading with the symbol "R" or "Rx", which stands for the word recipe (meaning, in Latin, to take); the inscription, which contains the names and quantities of the ingredients; the subscription or directions for compounding the drug; and the signature which is often preceded by the sign "s" standing for signa (Latin for mark), giving the directions to be marked on the container.
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Protein: A large molecule composed of one or more chains of amino acids in a specific order determined by the base sequence of nucleotides in the DNA coding for the protein.
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Psoralen: Any of a number of drugs and other substances containing chemicals that react with ultraviolet (UV) light to cause darkening of the skin.
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Psoriasis : A reddish, scaly rash often located over the surfaces of the elbows, knees, scalp, and around or in the ears, navel, genitals or buttocks. Psoriasis is an autoimmune disease that is mediated by T lymphocytes. It is also a very common disease, Chronic plaque psoriasis affects approximately 2% of people around the world. About 10-15% of patients with psoriasis develop joint inflammation (inflammatory arthritis ). Treatment options include topical steroid creams, tar soap preparations, and exposure to ultraviolet light.
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Psoriatic arthritis: Joint inflammation associated with psoriasis . Psoriatic arthritis is a potentially destructive and deforming form of arthritis that affects approximately 10% of persons with psoriasis.
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Puberty: A complex biologic and psychologic process involving sexual development, accelerated growth, and adrenal maturation heralded by the secretion of gonadotropin releasing hormone (GnRH) from a part of the brain called the hypothalamus . This event is the first known step in the reproductive cascade. It initiates the pulsatile release of gonadotropins , gonadal secretion of sex steroids, pubertal development, and gametogenesis (the production of sperm and ova ).
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Pus: A thick whitish-yellow fluid which results from the accumulation of white blood cells (WBCs), liquified tissue and cellular debris. Pus is commonly a site of infection or foreign material in the body.
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Pustular psoriasis: A type of recurring psoriasis characterized by the appearance of pus-filed pimples and sores in clusters. It can be intensely painful, and hospitalization may be required.
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PUVA: PUVA stands for psoralen (P) and ultraviolet A (UVA) therapy in which the patient is exposed first to psoralens (drugs containing chemicals that react with ultraviolet light) and then to UVA light.
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Quality of life: An important consideration in medical care, quality of life refers to the patient's ability to enjoy normal life activities. Some medical treatments can seriously impair quality of life without providing appreciable benefit, while others greatly enhance quality of life.
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Regimen: With the accent on the first syllable (reg as in Reggie Jackson), a regimen is a plan, a regulated course such as a diet, exercise or treatment, designed to give a good result. A low-salt diet is a regimen.
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Registry: Although a registry was originally the place (like Registry House in Edinburgh) where information was collected (in registers), the word registry has also come to mean the collection itself. A registry is usually organized so the data can be analyzed. For example, analysis of data in a tumor registry maintained at a hospital may show a rise in lung cancer among women.
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Remission: Disappearance of the signs and symptoms of cancer or other disease. When this happens, the disease is said to be "in remission." A remission can be temporary or permanent.
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Resistance: Opposition to something, or the ability to withstand it. For example, some forms of staphylococcus are resistant to treatment with antibiotics.
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Retinoid: 1. Vitamin A ( retinol ) or a naturally occurring or synthetic substance chemically related to it. (Retinoid literally means "like retinol.")
2. In ophthalmology , resembling the retina .
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Rheumatologist: A specialist in the non-surgical treatment of rheumatic illnesses, especially arthritis .
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Risk factor: Something that increases a person's chances of developing a disease.
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Rule out: A term much used in medicine, meaning to eliminate or exclude something from consideration. The ACB (albumin cobalt binding) test helps rule out a heart attack in the differential diagnosis of severe chest pain.
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Salicylic acid: A substance obtained from plants (white willow back and wintergreen leaves) and also synthesized which is versatile and possesses bacteriostatic , fungicidal, and keratolytic actions.
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Scaling: Abnormal shedding or accumulation of an upper layer of skin (the stratum corneum ).
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Seborrheic dermatitis: A medical name for what is popularly called seborrhea .
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Sensitivity: 1. In psychology, the quality of being sensitive. As, for example, sensitivity training, training in small groups to develop a sensitive awareness and understanding of oneself and of ones relationships with others. 2. In disease epidemiology, the ability of a system to detect epidemics and other changes in disease occurrence. 3. In screening for a disease, the proportion of persons with the disease who are correctly identified by a screening test. 4. In the definition of a disease, the proportion of persons with the disease who are correctly identified by defined criteria.
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Sperm: A sperm is the male "gamete" or sex cell. It combines with the female "gamete," called an ovum, to form a zygote. The formation process is called "fertilization." (see ovum, zygote).
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Stress: Forces from the outside world impinging on the individual. Stress is a normal part of life that can help us learn and grow. Conversely, stress can cause us significant problems.
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Sunburn: Sunburn is an inflammation of the skin that develops in response to exposure to ultraviolet (UV) radiation from the sun or from tanning beds and booths that emit UV radiation . Sunburn is manifested by reddened, painful skin that may develop blisters.
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Surgery: The word "surgery" has multiple meanings. It is the branch of medicine concerned with diseases and conditions which require or are amenable to operative procedures. Surgery is the work done by a surgeon. By analogy, the work of an editor wielding his pen as a scalpel is s form of surgery. A surgery in England (and some other countries) is a physician's or dentist's office.
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Systemic: Affecting the entire body. A systemic disease such as diabetes can affect the whole body. Systemic chemotherapy employs drugs that travel through the bloodstream and reach and affect cells all over the body.
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Systemic therapy: Treatment that reaches cells throughout the body by traveling through the bloodstream.
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Therapeutic: Relating to therapeutics , that part of medicine concerned specifically with the treatment of disease . The therapeutic dose of a drug is the amount needed to treat a disease.
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Therapy: The treatment of disease .
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Thigh: The thigh extends from the hip to the knee. The thigh has only one bone, the femur which is the largest bone in the human body.
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Throat: The throat is the anterior (front) portion of the neck beginning at the back of the mouth , consisting anatomically of the pharynx and larynx . The throat contains the trachea and a portion of the esophagus .
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Tongue: The tongue is a strong muscle anchored to the floor of the mouth. It is covered by the lingual membrane which has special areas to detect tastes.
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Topical: Pertaining to a particular surface area. A topical agent is applied to a certain area of the skin and is intended to affect only the area to which it is applied. Whether its effects are indeed limited to that area depends upon whether the agent stays where it is put or is absorbed into the blood stream.
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Trigger: Something that either sets off a disease in people who are genetically predisposed to developing the disease, or that causes a certain symptom to occur in a person who has a disease. For example, sunlight can trigger rashes in people with lupus .
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Ultraviolet A: One of the three types of invisible light rays (together with ultraviolet B and ultraviolet C) given off by the sun.
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Ultraviolet B: One of the three types of invisible light rays (together with ultraviolet A and ultraviolet C) given off by the sun.
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Vitamin D: A steroid vitamin which promotes the intestinal absorption and metabolism of calcium and phosphorus . Under normal conditions of sunlight exposure, no dietary supplementation is necessary because sunlight promotes adequate vitamin D synthesis in the skin. Deficiency can lead to bone deformity ( rickets ) in children and bone weakness (osteomalacia) in adults.
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White blood cell: One of the cells the body makes to help fight infections. There are several types of white blood cells ( leukocytes ). The two most common types are the lymphocytes and neutrophils (also called polymorphonuclear leukocytes, PMNs, or "polys").
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