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Pustular Psoriasis (cont.)

Pustular Psoriasis Causes

To best understand the causes of pustular psoriasis, one must know the causes of classical plaque-type psoriasis. It is generally agreed that a combination of genetics and environment induce psoriasis, including this pustular subtype. Below is a list of factors that are known to be associated with pustular psoriasis:

  • Taking systemic steroids (steroid medications given by mouth or by injection) and then discontinuing them
  • Taking various medications, including the following
    • Salicylates, compounds made from salicylic acid, often used to treat pain and fever
    • Oral iodides (SSKI)
    • Lithium or trazodone, antidepressants
    • Phenylbutazone or oxyphenbutazone, nonsteroidal anti-inflammatory drugs (NSAIDs)
    • Penicillin, an antibiotic
    • Hydroxychloroquine, an antimalarial drug
    • Calcipotriol, a vitamin-D derivative
    • Interferon alfa and recombinant interferon-beta injections, chemotherapeutic agents
    • TNF-blocking biologic medications, such as infliximab (Remicade)
  • Strong, irritating topical solutions (creams or ointments applied to the skin), including tar, anthralin, steroids under occlusion, and zinc pyrithione in shampoo
  • Infections
  • Pregnancy
  • Sunlight or phototherapy
  • Cholestatic jaundice (a yellowish staining of the skin and eyes, caused by bile)
  • Hypocalcemia (abnormally low levels of calcium in the blood)

In many people, the trigger is never identified.

Medically Reviewed by a Doctor on 5/8/2014

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Pustular Psoriasis - Symptoms

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Read What Your Physician is Reading on Medscape

Psoriasis, Pustular »

Pustular psoriasis is an uncommon form of psoriasis consisting of widespread pustules on an erythematous background

Read More on Medscape Reference »


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