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PUVA Therapy (cont.)

PUVA Therapy Risks and Side Effects

PUVA can potentially cause skin cancer, just as does natural ultraviolet light. In addition, because of the intensity and duration over which it may be given, patients are at greater risk to develop squamous cell skin cancers and melanomas in treated skin than would otherwise be the case. In addition, excessive aging of the skin and a mottled sort of pigmented appearance (poikiloderma) is likely to occur in the areas treated. Although rare, serious burns are possible because of inadvertent overdosage of UVA. Patient's must limit their environmental exposure to sunlight for 24 hours after taking psoralens.

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