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Medications and Drugs

Brand Names: Ranexa

Generic Name: ranolazine (Pronunciation: ra NOE la zeen)

What is ranolazine (Ranexa)?

Ranolazine is an anti-anginal medication. It works by improving blood flow to help the heart work more efficiently.

Ranolazine is used to treat chronic angina (chest pain). Ranolazine is not for use during an acute (emergency) attack of angina.

Ranolazine may also be used for purposes not listed in this medication guide.

Ranexa 500 mg

oval, yellow, imprinted with CVT500

What are the possible side effects of ranolazine (Ranexa)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • feeling like you might pass out;
  • swelling in your hands, ankles, or feet;
  • slow, fast, or pounding heartbeats;
  • tremors or shaking;
  • blood in your urine;
  • urinating less than usual or not at all;
  • shortness of breath; or
  • skin rash, bruising, severe tingling, numbness, pain, and muscle weakness.

Less serious side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about ranolazine (Ranexa)?

You should not take ranolazine if you have cirrhosis of the liver. There are many other drugs that should not be used together with ranolazine. Tell your doctor about all other medicines you use.

Ranolazine is not for use during an acute (emergency) attack of angina. Continue using any other medicines prescribed by your doctor (such as nitroglycerin) to treat acute angina.

Before you take ranolazine, tell your doctor about all of your medical conditions, especially if you have a personal or family history of Long QT syndrome.

Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time.

Chronic angina is often treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Do not change your doses or medication schedule without advice from your doctor.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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