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May 18, 2013
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Restless Legs Syndrome (RLS)

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Restless Legs Syndrome (RLS) Overview

Restless legs syndrome (RLS) is a disorder of the part of the nervous system that affects movements of the legs. Because it usually interferes with sleep, it also is considered a sleep disorder.

  • People with RLS have strange sensations in their legs (and sometimes arms) and an irresistible urge to move their legs to relieve the sensations.
  • The sensations are difficult to describe: they are not painful, but an uncomfortable, "itchy," "pins and needles," or "creepy crawly" feeling deep in the legs.
  • The sensations are usually worse at rest, especially when lying in bed.
  • The sensations lead to walking discomfort, sleep deprivation, and stress.

RLS affects about 8%-10% of the US population. Men and women are affected equally. It may begin at any age, even in infants and young children. Most people who are affected severely are middle-aged or older.

The severity of RLS symptoms ranges from mild to intolerable. Symptoms get gradually worse over time in about two thirds of people with the condition and may be severe enough to be disabling. The symptoms are generally worse in the evening and night and less severe in the morning. While the symptoms are usually quite mild in young adults, by age 50 the symptoms cause severe nightly sleep disruption that leads to decreased alertness in the daytime.

RLS is often unrecognized or misdiagnosed. In many people the condition is not diagnosed until 10-20 years after symptoms begin. Once correctly diagnosed, RLS can often be treated successfully.

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Restless Leg Syndrome - Treatment

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Restless Legs Syndrome (RLS) Medications

Medications are usually helpful but no single medication effectively manages RLS for all individuals. Trials of different drugs may be necessary. In addition, medications taken regularly may lose their effect over time, making it necessary to change medications periodically.

Common drugs prescribed to treat RLS include:

Dopaminergic agents (drugs that increase dopamine), largely used to treat Parkinson's disease, have been shown to reduce symptoms of RLS and PLMS when they are taken at bedtime and are considered the initial treatment of choice.

Other medications may be prescribed "off-label" (not specifically designed to treat RLS) to relieve some of the symptoms of the disorder.

Benzodiazepines can help individuals who have mild or intermittent symptoms obtain a more restful sleep. However, even if taken only at bedtime they can sometimes cause daytime sleepiness.

Opioids such as codeine, propoxyphene, or oxycodone may be prescribed at night to diminish pain and help to relax individuals with more severe symptoms.

Anticonvulsants such as gabapentin and pregabalin can decrease the sensory disturbances such as creeping and crawling sensations and nerve pain.

SOURCE:
National Institutes of Health. Restless Legs Syndrome Fact Sheet.

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Read What Your Physician is Reading on Medscape

Restless Legs Syndrome »

The term restless legs syndrome (RLS) was used initially in the mid-1940s by Swedish neurologist Karl A. Ekbom to describe a disorder characterized by sensory symptoms and motor disturbances of the limbs, mainly during rest.

Read More on Medscape Reference »


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