Riboflavin (Vitamin B2)

Are there any interactions with medications?

---

Drying medications (Anticholinergic drugs)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Some drying medications can affect the stomach and intestines. Taking these drying medications with riboflavin (vitamin B2) can increase the amount of riboflavin that is absorbed in the body. But it's not known if this interaction is important.

---

Medications for depression (Tricyclic antidepressants)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Some medications for depression can decrease the amount of riboflavin in the body. This interaction is not a big concern because it only occurs with very large amounts of some medications for depression.

---

Phenobarbital (Luminal)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Riboflavin is broken down by the body. Phenobarbital might increase how quickly riboflavin is broken down in the body. It is not clear if this interaction is significant.

---

Probenecid (Benemid)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Probenecid (Benemid) can increase how much riboflavin is in the body. This might cause there to be too much riboflavin in the body. But it's not known if this interaction is a big concern.

Dosing considerations for Riboflavin (vitamin B2).

The following doses have been studied in scientific research:

BY MOUTH:

• For treating low levels of riboflavin (riboflavin deficiency) in adults: 5-30 mg of riboflavin (Vitamin B2) daily in divided doses.
• For preventing migraine headaches: 400 mg of riboflavin (Vitamin B2) per day. It may take up to three months to get best results.
• For preventing cataracts: a daily dietary intake of approximately 2.6 mg of riboflavin (Vitamin B2) has been used. A combination of 3 mg of riboflavin (Vitamin B2) plus 40 mg of niacin daily has also been used.
• The daily recommended dietary allowances (RDAs) of riboflavin (Vitamin B2) are: Infants 0-6 months, 0.3 mg; infants 7-12 months, 0.4 mg; children 1-3 years, 0.5 mg; children 4-8 years, 0.6 mg; children 9-13 years, 0.9 mg; men 14 years or older, 1.3 mg; women 14-18 years, 1 mg; women over 18 years, 1.1 mg; pregnant women, 1.4 mg; and breastfeeding women, 1.6 mg.