Definition of CalfCalf: The belly or fleshy hind part of the back of the leg below the knee. The calf is made up mainly of the gastrocnemius muscle. Pain in the calf is commonly caused by muscle strain, but can be caused by blood clots in veins of the legs. Source: MedTerms™ Medical Dictionaryhttp://www.medterms.com/script/main/art.asp?articlekey=10341 Last Editorial Review: 3/19/2012
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