Definition of Headache, reboundHeadache, rebound: A headache experienced by someone who has taken pain relievers for migraines or other health conditions and has built up a tolerance for these medications. Often a rebound headache occurs right after the medication wears off. Treatment involves using the medication less frequently or switching to a different pain reliever. Source: MedTerms™ Medical Dictionaryhttp://www.medterms.com/script/main/art.asp?articlekey=11400 Last Editorial Review: 3/19/2012
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