Definition of LevothyroxineLevothyroxine: A synthetic thyroid hormone used as a thyroid hormone replacement drug (brand names include Levothroid, Levoxine, Levoxyl, Synthroid) used to treat an underactive thyroid gland (hypothyroidism). Source: MedTerms™ Medical Dictionaryhttp://www.medterms.com/script/main/art.asp?articlekey=11595 Last Editorial Review: 9/20/2012
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