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Obesity After Age 50 Raises Diabetes Risk

Increased Diabetes Risk Exists to a Lesser Extent After Age 75, Study Finds

By Salynn Boyles
WebMD Health News

Reviewed By Laura J. Martin, MD

June 23, 2010 -- Obesity and weight gain increase the risk for diabetes in the elderly, but the association is not as strong after age 75 as it is for younger adults, a new study finds.

Researchers followed people over age 65 for more than a decade in one of the largest and longest studies ever to examine the impact of obesity and weight gain on diabetes risk in the elderly.

Overall, people in the study who weighed the most were two to six times as likely to develop diabetes during the follow-up as people who weighed the least.

People who were obese at age 50 and gained 20 pounds or more prior to entering the study were five times as likely to develop diabetes as people who were not overweight and did not gain weight.

The study appears in the June 23/30 issue of the Journal of the American Medical Association.

"We already knew it was important to maintain an optimal weight to lower diabetes risk, and this study finds that it remains important into old age," lead researcher Mary L. Biggs, PhD, of the University of Washington, Seattle, tells WebMD.

Age, Obesity, and Diabetes

The study included 4,193 adults aged 65 and older (median age was 73) followed for an average of 12.4 years. During the follow-up, 339 new cases of diabetes were identified.

Biggs and colleagues examined several measures of obesity, including body mass index (BMI) at study entry, BMI at age 50, weight, waist circumference, and waist-to-hip ratio.

All of these measures were strongly related to diabetes risk, as was weight gain after age 50, Biggs says.

Specifically:

  • Compared to people whose weight remained relatively stable, people who were normal weight before age 50 and who gained 20 pounds or more after age 50 and before entering the study had a threefold greater risk for developing diabetes during the follow-up.
  • Diabetes risk was four times greater for study participants who had the highest BMIs and biggest waist circumferences.
  • Compared to people whose waist size remained relatively unchanged, people whose waist grew by more than 4 inches over the follow-up period had a 70% higher risk of developing diabetes.

Among people older than 75 when they entered the study, those who were overweight or obese were twice as likely to develop diabetes.

"Obesity-associated risk does seem to wane some as people get older," Biggs says. "But the important message was that there was still a relationship."

Is Obesity Less Risky in Elderly People?

A number of recent studies have found that being overweight or obese is not as deleterious to health in old age as it is earlier in life.

Research published early this year found that being overweight after age 70 was associated with a lower risk for death than for people who were normal weight, underweight, or obese.

If the impact of obesity on diabetes risk really does decline with age, as the newly published study suggests, this could be seen as more evidence that carrying extra weight is not as dangerous in the elderly as has widely been believed.

But Biggs is not so sure.

"I would be cautious about making too much of this finding until it is confirmed in other studies," she says.

Geriatric diabetes specialist Medha Munshi, MD, at Boston's Joslin Diabetes Center, treats mostly patients who are age 75 and older.

Although some of her patients are newly diagnosed, most have been managing their diabetes for many years.

She says she rarely puts her elderly patients on diets, but she does stress the importance of exercise.

"With age, you lose muscle and gain fat," she says. "When older people try to lose weight simply by dieting they are likely to lose much-needed muscle mass. Exercise, especially weight-bearing exercise, is important in older people not just for diabetes but for quality of life."

SOURCES: Biggs, M.L. Journal of the American Medical Association, June 23/30, 2010; vol 303: pp 2504-2512.

Mary L. Biggs, PhD, research scientist, University of Washington, Seattle.

Medha Munshi, MD, geriatric diabetes specialist, Joslin Diabetes Center, Boston.

News release, Journal of the American Medical Association.

WebMD Health News: "Overweight Older People Live Longer."

©2010 WebMD, LLC. All Rights Reserved.





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