Leflunomide for Rheumatoid Arthritis
Leflunomide is given by mouth (orally).
How It Works
Leflunomide (Arava) is a disease-modifying antirheumatic drug (DMARD) that is used to treat rheumatoid arthritis. Leflunomide (Arava) is a disease-modifying antirheumatic drug (DMARD) that is used to treat rheumatoid arthritis. It interferes with the progression of the disease by blocking the production of white blood cells that cause the joint inflammation in rheumatoid arthritis. Because it blocks the natural response of the immune system, leflunomide is considered an immunosuppressive drug.
Why It Is Used
Leflunomide is used to treat active rheumatoid arthritis in adults to relieve symptoms and slow the progression of the disease. Leflunomide is considered a choice for people with active rheumatoid arthritis who have not responded to methotrexate or sulfasalazine.1
How Well It Works
Leflunomide can improve symptoms, slow or prevent the disease from getting worse, and improve function in people with rheumatoid arthritis. It also seems to be well-tolerated and slows disease progression as seen on X-rays. 1
Side effects of leflunomide include:
Risk of infection
Leflunomide decreases the activity of your body's immune system, which increases the risk of a serious bacterial infection. Some people who take leflunomide develop an infection that requires oral antibiotics. A smaller number of people will develop an infection that requires intravenous antibiotics and hospitalization. Contact your health professional if you develop any of the following symptoms:
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
What To Think About
Leflunomide should not be used by pregnant women or women of childbearing age who are not using reliable birth control. Do not take leflunomide if you are breast-feeding. If you plan to become pregnant, check with your health professional before stopping birth control and trying to become pregnant. He or she probably will prescribe a medicine (cholestyramine) that will remove leflunomide from your body. Your health professional will then check to be sure that leflunomide is no longer detectable in your body.
People taking leflunomide will need regular monitoring of their liver function to check for signs of liver damage. Talk with your health professional before taking leflunomide if you have ever had liver, kidney, or immune system disease or a history of significant alcohol use.
Leflunomide may affect your immune system and your body's reaction to a live vaccination. Talk to your health professional before you receive a vaccination while taking leflunomide.
Because leflunomide is a relatively new medicine, its long-term safety and effectiveness are not known.1
eMedicineHealth Medical Reference from Healthwise
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