Clozapine for Schizophrenia
The U.S. Food and Drug Administration (FDA) approved clozapine for treating suicidal behavior associated with schizophrenia or for treating severe schizophrenia that has not improved with other medicines. Its use for treating other symptoms of schizophrenia has not yet been approved in the U.S., except through special authorization.
When you use this medicine, your name goes into the Clozaril National Registry so that if you have severe side effects, you are not given the medicine again.
How It Works
Clozapine is a second-generation antipsychotic. It is thought to affect the way brain chemicals (neurotransmitters) work.
Why It Is Used
Clozapine is used to treat the symptoms of schizophrenia if other medicines don't work or if the person may be thinking about suicide.
How Well It Works
Clozapine may reduce symptoms of schizophrenia that have not been controlled by other medicines.
Some warnings about serious side effects of clozapine have been issued.
A rare but possibly life-threatening side effect is agranulocytosis, a problem that causes your body to make fewer white blood cells. You need weekly blood cell tests during the first 6 months of treatment with this medicine and tests every 2 weeks after this period of time.1 This helps the doctor find this side effect early.
The most common side effects of clozapine are:
Other side effects include:
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
What To Think About
Because of the side effects, talk with your doctor about whether this medicine is right for you. If you have had a seizure, heart or blood vessel problems, or liver or kidney problems, you probably should not take clozapine.
It is not known whether clozapine is safe for children, older adults, and nursing women.
Because clozapine does not have some of the bothersome side effects of the first-generation antipsychotic medicines, people who have schizophrenia may be more likely to take it regularly.
eMedicineHealth Medical Reference from Healthwise
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