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Benefits and Risks of Early Antiretroviral Therapy for HIV

Benefits and Risks of Early Antiretroviral Therapy for HIV

Early antiretroviral therapy may offer benefits to people with HIV who have a CD4+ cell count greater than 500.1 You should not start antiretroviral therapy until you have thought about these benefits and risks and discussed all the issues with your doctor.

Benefits and risks of antiretroviral therapy for HIV
Type of therapy

Early therapy: Treatment with antiretroviral medicines before CD4+ cell count drops below 500

Delayed therapy: Treatment with antiretroviral medicines after CD4+ cell count drops below 500

  • Increases ability to achieve and maintain control of viral replication
  • Delays or prevents immune system compromise
  • Slows or prevents progression of HIV to AIDS
  • Lowers risk of resistance to the medicines, if viral suppression is complete
  • Possibly reduces risk of HIV transmission. Even with early therapy, the risk of HIV transmission still exists. Antiretroviral therapy cannot substitute for primary HIV prevention measures, such as condom use and safer sex practices.
  • Avoids negative effects on quality of life, such as the cost of the medicine
  • Avoids serious problems related to the medicines
  • Delays development of resistance to the medicines
  • Preserves the maximum number of medicine options when HIV disease risk is highest
  • Medicine-related side effects that may reduce your quality of life
  • Earlier development of resistance to the medicines if viral suppression is not complete
  • Limitation of future antiretroviral treatment options
  • Possible risks of starting antiretroviral therapy before HIV-related symptoms develop
  • Irreversible damage to the immune system, which might have been avoided by earlier treatment
  • Greater chance of getting sick
  • Greater difficulty in preventing the virus from multiplying
  • Possible increase in the risk of HIV transmission
  • Increase in the risk of death from an AIDS-related illness



  1. U.S. Department of Health and Human Services (2009). Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Available online:


ByHealthwise Staff
Primary Medical ReviewerE. Gregory Thompson, MD - Internal Medicine
Specialist Medical ReviewerPeter Shalit, MD, PhD - Internal Medicine
Last RevisedApril 8, 2010

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