Danazol for Endometriosis
Danazol is a synthetic form of the male hormone testosterone.
How It Works
Danazol is a drug that lowers estrogen levels and increases androgen levels. This puts the body in a state that is like menopause and can cause some male physical traits, as well. As a result, danazol:
Why It Is Used
Danazol is occasionally used to treat endometriosis, usually when all other hormone therapies have not helped. Danazol can:
Danazol is not widely used to treat endometriosis and other estrogen-related conditions, because it can cause serious side effects. Because of these serious side effects, such as increased cholesterol levels, danazol use is limited to 6 to 9 months at a time. Danazol may not be appropriate if you already have a high risk for developing increased cholesterol levels or liver disease.
Reasons not to use danazol include:
How Well It Works
Up to 90% of women who use danazol report improvement in symptoms of endometriosis.1 Relief is likely to be noticeable within a few months after starting treatment. Pain relief typically lasts for 6 to 12 months after stopping treatment.
Like all hormone therapies and surgery for endometriosis, danazol does not cure the disease.
Danazol does not improve infertility caused by endometriosis.
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.
Here are some important things to think about:
Call your doctor if you have:
Common side effects of this medicine include:
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
What To Think About
Danazol may cause your skin to be more sensitive to sunlight. When you are taking this medicine:
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.
There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.
Advice for women
Do not use this medicine if you are pregnant or planning to get pregnant. If you need to use this medicine, talk to your doctor about how you can prevent pregnancy.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
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