Thiazolidinediones for Type 2 Diabetes
Thiazolidinediones are also available in combination pills. Pioglitazone is combined with the biguanide medicine metformin (Actoplus Met) and sulfonylurea medicine glimepiride (Duetact). Rosiglitazone is combined with metformin (Avandamet) and the sulfonylurea medicine glimepiride (Avandaryl).
How It Works
These medicines lower insulin resistance in muscle and fat. They also reduce glucose produced by the liver.
Why It Is Used
Thiazolidinediones are usually used when other medicines have failed to lower blood sugar levels into a target range.
These medicines sometimes lower triglycerides and raise HDL cholesterol.
How Well It Works
Type 2 diabetes is a disease that can get worse over time, so medicines may need to change.
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.
Here are some important things to think about:
Call your doctor immediately if you have:
Common side effects of this medicine include:
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
What To Think About
Women who have stopped menstruating before they start taking these medicines may begin menstruating again and may become pregnant. Also, women who take oral contraceptives to prevent pregnancy may become pregnant.
Women who take rosiglitazone (Avandia) or pioglitazone (Actos) may increase their risk for upper arm or foot fractures, according to a warning from the U.S. Food and Drug Administration (FDA).
The FDA has announced possible safety issues with the drugs rosiglitazone (Avandia) and pioglitazone (Actos). Some studies have shown that people who take Avandia may raise their chance of having a heart attack, and people who take Actos may raise their chance of bladder cancer.
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.
There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.
Advice for women
If you are pregnant, breast-feeding, or planning to get pregnant, do not use any medicines unless your doctor tells you to. Some medicines can harm your baby. This includes prescription and over-the-counter medicines, vitamins, herbs, and supplements. And make sure that all your doctors know that you are pregnant, breast-feeding, or planning to get pregnant.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
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