Cholinergics for Glaucoma
Most of these medicines are given in eyedrop form. Pilocarpine can be given as a gel form (Pilopine).
Cholinergic medicine eyedrops have green bottle caps. If you need to use more than one type of eyedrop, you may need to take each medicine in a certain order. You can use the color of the bottle cap to help you remember when to use each type of eyedrop.
If you are using more than one type of eyedrop, wait 5 minutes between the different eyedrop medicines.
How It Works
Why It Is Used
Like beta-blockers, cholinergics can be used alone or combined with other glaucoma medicines. A combination of medicines can help control how much fluid is produced in the eye and increase the amount of fluid that drains out of the eye.
Cholinergic medicines may be used during an episode of closed-angle glaucoma after the pressure inside the eye has been reduced.
Cholinergics are one of the oldest types of medicines used to treat glaucoma. But because they can cause significant side effects, and there are other effective medicines to treat glaucoma, cholinergic medicines are not used as frequently as in the past.
How Well It Works
These medicines have the strongest effect on the pressure in the eye during the 2 to 4 hours after medicine is applied. The medicine continues to work for 4 to 8 hours after use.
Side effects of cholinergics include:
Report any change in your vision, including dimmer sight, flashing lights, or floating spots. Also tell your doctor right away if you have any loss of eyesight.
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
What To Think About
Pilocarpine has few side effects on the rest of the body. But it is not used as often as other medicines, because it causes blurred vision and works for only a short time. Many people find it uncomfortable to apply pilocarpine because of the stinging feeling that the medicine causes.
Compared to pilocarpine eyedrops, pilocarpine gel (Pilopine) can be applied once each day. But the gel is more expensive than the eyedrops. For some people it may be harder to use than eyedrops.
Echothiophate needs to be stopped several weeks before surgery if a certain general anesthetic (succinylcholine) is going to be used. Using echothiophate while receiving this anesthetic could increase the risk of breathing problems (respiratory paralysis).
Cholinergics are more powerful when combined with a carbonic anhydrase inhibitor (such as dorzolamide [Trusopt] or brinzolamide [Azopt]). Newer combinations that are also an additive include pilocarpine and latanoprost (Xalatan). But when a combination of medicines is used, the person may need to put in different eyedrops as many as 8 times a day.
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