Leukotriene Pathway Modifiers for Long-Term Control of Asthma
These medicines are available as pills and chewable tablets.
How It Works
Leukotriene pathway modifiers improve lung function and decrease asthma symptoms.
Why It Is Used
Leukotriene pathway modifiers are used to treat people with persistent asthma who need daily medicine to control inflammation of the airways leading to the lungs (bronchial tubes).
These medicines may be given along with inhaled corticosteroids to control mild persistent and moderate persistent asthma. They may be especially helpful for people whose asthma is triggered by exercise, aspirin, or allergies.
Different types of medicines are often used together in the treatment of asthma. Treatment for asthma depends on a person's age, his or her type of asthma, and how well the treatment is controlling asthma symptoms.
Your doctor will work with you to help find the number and dose of medicines that work best.
How Well It Works
Research shows that compared with a placebo, leukotriene pathway modifiers:
But leukotriene pathway modifiers are not as effective as inhaled corticosteroids. And adding leukotrienes to inhaled corticosteroids is not as effective as adding long-acting beta2-agonists to inhaled corticosteroids.1
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.
Here are some important things to think about:
Common side effects of this medicine include:
In rare cases, zafirlukast and zileuton cause liver damage. If the liver is being affected by zafirlukast or zileuton, liver function tests will show increased liver enzyme levels in the blood, usually within the first 2 months of treatment.
Montelukast causes fewer side effects than other leukotriene pathway modifiers. It is less likely to affect the liver, so liver function monitoring is not needed.
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
What To Think About
The U.S. National Asthma Education and Prevention Program (NAEPP) recommends leukotriene pathway modifiers as an alternative treatment for people who have mild or persistent asthma. Preferred medicines are inhaled corticosteroids with or without long-acting beta2-agonists.3
People who take zafirlukast and medicine to prevent blood clots (such as warfarin) need to have their clotting times checked regularly. When used with blood-thinning medicine, zafirlukast can increase the risk of bleeding. Zafirlukast also may cause problems when taken with other medicines, such as blood pressure medicines, aspirin, and some seizure medicines. Before you take zafirlukast, make sure your doctor knows that you are taking any of those medicines.
Montelukast can be given to people age 2 and older. It is given once a day. Zafirlukast can be given to people age 5 and older. It is given twice a day. Zileuton has not been approved by the U.S. Food and Drug Administration (FDA) for use in children.
People who are taking zafirlukast or zileuton need to have liver function tests several times during the first 6 months of treatment. People who are taking theophylline along with zileuton may need to take less theophylline.
People who take leukotriene pathway modifiers may be more likely to take their medicine regularly, because it can be taken orally and has a more immediate effect on symptoms than some other medicines such as inhaled corticosteroids.
Leukotriene pathway modifiers are not used to treat asthma attacks.
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.
There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.
Advice for women
If you are pregnant, breast-feeding, or planning to get pregnant, do not use any medicines unless your doctor tells you to. Some medicines can harm your baby. This includes prescription and over-the-counter medicines, vitamins, herbs, and supplements. And make sure that all your doctors know that you are pregnant, breast-feeding, or planning to get pregnant.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
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